Analysis of high-risk factors of severe cardiovascular sequelae in Kawasaki disease

MU Zhilong; GAO Ying; JIAO Fuyong; WEI Li

doi:10.7619/jcmp.20230476

Journal of Clinical Medicine in Practice > 2023 > 27(11): 75-79. > DOI: 10.7619/jcmp.20230476

MU Zhilong, GAO Ying, JIAO Fuyong, WEI Li. Analysis of high-risk factors of severe cardiovascular sequelae in Kawasaki disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(11): 75-79. DOI: 10.7619/jcmp.20230476

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Analysis of high-risk factors of severe cardiovascular sequelae in Kawasaki disease

MU Zhilong^{1, 2},
GAO Ying^{1, 2},
JIAO Fuyong^{1, 2},
WEI Li^{1, 2, ,}

1.
Department of Pediatrics, Shaanxi Provincial People′s Hospital, Xi′an, Shaanxi, 710068
2.
Department of Pediatrics, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Xi′an, Shaanxi, 710068

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Received Date: February 19, 2023
Revised Date: April 21, 2023
Available Online: June 24, 2023

Graphical Abstract

Abstract

Abstract

Objective
To analyze the high-risk factors of severe cardiovascular sequelae (SCS) in children with Kawasaki disease (KD).
Methods
A total of 505 KD patients were selected and divided into non-severe cardiovascular sequelae (N-GS) group (474 cases) and SCS group (31 cases) according to the presence of coronary artery disease (CAL). Age, gender, peripheral blood white blood cell count (WBC), fever duration, hemoglobin (Hb), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), plasma D-dimer assay (DD), antistreptomolysin O assay (ASO), Epstein-Barr virus (EBV), intravenous immunoglobulin (IVIG) nonresponse and recurrence of KD were correlated with KD complicated with SCS. The high-risk factors of KD concurrent SCS were analyzed.
Results
Single factor analysis showed that ESR, PCT, fever time >10 days, KD recurrence and IVIG nonresponse were related to KD complicated with SCS (P < 0.05). Logistic regression analysis showed that fever time >10 days (OR=6.73; 95%CI, 1.75 to 22.94; P=0.02), KD recurrence (OR=3.87; 95%CI, 1.43 to 8.55; P=0.04) and IVIG nonresponse (OR=4.28; 95%CI, 1.62 to 9.75; P=0.03) were independent high-risk factors for KD complicated with SCS.
Conclusion
Fever time >10 days, KD recurrence and IVIG nonresponse are high-risk factors for KD complicated with SCS.
- Kawasaki disease,
- children,
- severe cardiovascular sequelae,
- risk factors,
- immunoglobulin intravenous,
- injection of immunoglobulin

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References (19)

References

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