Advance Search
ZHAO Tianzhen, PANG Kun, WANG Xiaohua, JU Xing, HU Yue. Efficacy of risperidone combined with clozapine in the treatment of vagrants with schizophrenia[J]. Journal of Clinical Medicine in Practice, 2023, 27(22): 86-89, 94. DOI: 10.7619/jcmp.20232964
Citation: ZHAO Tianzhen, PANG Kun, WANG Xiaohua, JU Xing, HU Yue. Efficacy of risperidone combined with clozapine in the treatment of vagrants with schizophrenia[J]. Journal of Clinical Medicine in Practice, 2023, 27(22): 86-89, 94. DOI: 10.7619/jcmp.20232964
shu

Efficacy of risperidone combined with clozapine in the treatment of vagrants with schizophrenia

  • 1.

    Department of Psychiatry, Qinhuangdao Jiulongshan Hospital of Hebei Province, Qinhuangdao, Hebei, 066000

  • 2.

    Department of Psychology, Qinhuangdao Jiulongshan Hospital of Hebei Province, Qinhuangdao, Hebei, 066000

More Information
  • Received Date: September 17, 2023
  • Revised Date: October 23, 2023
  • Available Online: December 05, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To observe the effect of risperidone combined with clozapine in the treatment of vagrants with schizophrenia and its influence on social function of the patients.

    Methods 

    Eighty patients with vagrant schizophrenia were selected as the study objects by a prospective randomized controlled trial, and were randomly divided into control group (40 cases) and observation group (40 cases). The control group was treated with risperidone, and the observation group was treated with risperidone and clozapine. Both groups received continuous treatment for 8 weeks. The clinical effects of the two groups were observed. The activities of daily living, rehabilitation[Inpatient Psychiatric Rehabilitation Efficacy Rating Scale (IPROS) score], social function, myocardial enzyme profile[lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB)] in the two groups before treatment and eight weeks after treatment were compared. The adverse reactions of the two groups were statistically analyzed.

    Results 

    The total effective rate of treatment in the observation group was higher than that of the control group (90.00% versus 72.50%, P < 0.05). After eight weeks of treatment, the abilities of daily living and social function of the two groups were stronger than before treatment, and the observation group was stronger than the control group. At 8 weeks of treatment, IPROS scores in two groups were lower than before treatment, and observation group was lower than control group (P < 0.05). After 8 weeks of treatment, LDH, CK and CK-MB levels in two groups were higher than before treatment (P < 0.05), but there was no statistical significant between-group difference (P > 0.05).

    Conclusion 

    Risperidone combined with clozapine has a significant effect in thetreatment of vagrants with schizophrenia, which can enhance the patients'daily living ability and social ability, improve the rehabilitation status, and does not increase the adverse reactions.

    • FullText(HTML)
    • References (20)
  • [1]
    KHATIMAH C H, ADAMI A, ABDULLAH A, et al. Quality of life, mental health, and family functioning of schizophrenia caregivers: a community-based cross-sectional study[J]. Asia Pac Psychiatry, 2022, 14(1): e12467. doi: 10.1111/appy.12467
    [2]
    陈进良, 李婷, 李海波, 等. 流浪的精神分裂症患者应对方式和人格特征分析[J]. 临床精神医学杂志, 2020, 30(5): 333-336. doi: 10.3969/j.issn.1005-3220.2020.05.014
    [3]
    MOGHADDAM A H, MABOUDI K, BAVAGHAR B, et al. Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice[J]. Neurosci Lett, 2021, 765: 136249. doi: 10.1016/j.neulet.2021.136249
    [4]
    蔡丽莉, 刘峥荣, 李镔, 等. 社会支持与康复训练综合干预对城市流浪精神病患者的疗效研究[J]. 反射疗法与康复医学, 2022, 3(1): 122-125. https://www.cnki.com.cn/Article/CJFDTOTAL-FSKF202201035.htm
    [5]
    FIRST M B. Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility[J]. J Nerv Ment Dis, 2013, 201(9): 727-729. doi: 10.1097/NMD.0b013e3182a2168a
    [6]
    汪卫东, 刘寰忠, 李文正, 等. 精神分裂症患者发病前后饮酒行为与阳性和阴性症状量表评分的关联性研究[J]. 中国全科医学, 2020, 23(20): 2514-2519. doi: 10.12114/j.issn.1007-9572.2020.00.103.
    [7]
    李正禹, 武继磊, 李佳佳, 等. 慢性病对中国65岁及以上老年人日常活动能力影响的队列研究[J]. 中华流行病学杂志, 2019, 40(1): 33-40.
    [8]
    黄承保, 王小莉, 方惠民, 等. 虚拟现实技术支持下社交技能训练在中青年精神分裂症社交技能缺陷患者中的应用效果[J]. 实用心脑肺血管病杂志, 2019, 27(1): 87-91. https://www.cnki.com.cn/Article/CJFDTOTAL-SYXL201901023.htm
    [9]
    CHIU E C, HUNG T M, HUANG C M, et al. Responsiveness of the Personal and Social Performance scale in patients with schizophrenia[J]. Psychiatry Res, 2018, 260: 338-342. doi: 10.1016/j.psychres.2017.11.053
    [10]
    COLYER-PATEL K, TEEUW J, BROUWER R, et al. P. 321 Shared genetic and environmental influences on altered functional connectivity and schizophrenia liability[J]. Eur Neuropsychopharmacol, 2021, 44: S54-S55. doi: 10.1016/j.euroneuro.2021.01.082
    [11]
    RAUCHER-CHÉNÉD, THIBAUDEAU E, SAUVÉG, et al. Understanding others as a mediator between verbal memory and negative symptoms in schizophrenia-spectrum disorder[J]. J Psychiatr Res, 2021, 143: 429-435. doi: 10.1016/j.jpsychires.2021.10.007
    [12]
    吴海莲, 吴叶. 氨磺必利对精神分裂症患者阳性症状与阴性症状量表评分、催乳素水平、体质量及生活质量的影响[J]. 实用临床医药杂志, 2019, 23(20): 15-18. doi: 10.7619/jcmp.201920004
    [13]
    SEGARRA R, RECIO-BARBERO M, SÁENZ-HERRERO M, et al. Oral and palmitate paliperidone long-acting injectable formulations' use in schizophrenia spectrum disorders: a retrospective cohort study from the first episode psychosis intervention program (CRUPEP)[J]. Int J Neuropsychopharmacol, 2021, 24(9): 694-702. doi: 10.1093/ijnp/pyab021
    [14]
    覃文刚, 韩翠兰, 肖攀攀, 等. 难治性精神分裂症氯氮平联合用药的疗效及安全性研究[J]. 临床精神医学杂志, 2022, 32(3): 231-235. https://www.cnki.com.cn/Article/CJFDTOTAL-LCJS202203017.htm
    [15]
    张轩, 张鸿鹤. 氯氮平对精神分裂症患者慢波睡眠及认知功能影响的研究进展[J]. 国际精神病学杂志, 2022, 49(4): 580-582, 586. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202204047.htm
    [16]
    肖慧琼, 李冬凤, 梁小丽, 等. 氯氮平联合穴位埋线法对精神分裂症顽固性幻听患者的代谢影响及临床疗效[J]. 湖南中医药大学学报, 2020, 40(8): 981-986. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZX202008013.htm
    [17]
    ALLOZA C, BLESA-CÁBEZ M, BASTIN M E, et al. Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank[J]. Transl Psychiatry, 2020, 10(1): 122.
    [18]
    耿小雨, 杨贵成, 张景景, 等. 氯氮平和氯丙嗪对维持期精神分裂症认知功能与述情障碍的影响[J]. 国际精神病学杂志, 2020, 47(6): 1142-1144, 1147. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202006015.htm
    [19]
    董捍东, 陈传奇, 孙丽娟, 等. 利培酮、喹硫平、氯氮平及奥氮平对老年精神分裂症患者的QTc间期延长的影响[J]. 国际精神病学杂志, 2021, 48(2): 233-236. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202102012.htm
    [20]
    奚丽华, 张红霞, 黄惠珍. 氯氮平治疗精神性疾病所致心脏不良反应发生的危险因素分析[J]. 海南医学, 2022, 33(4): 424-427. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202204005.htm
    • Related Articles

  • Related Articles

    [1]GAO Xianru, ZENG Qingping, LI Mengyao, LI Yuping, TAN Yuerong, WANG Jia, SHI Tian. Bibliometric analysis of domestic and foreign studies on dysphagia after stroke in the past decade[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 127-133. DOI: 10.7619/jcmp.20223226
    [2]YANG Ling, LEI Ming, CHEN Qun, ZHAO Xiao, YU Xiaoxia. Clinical study on Weijin Xiangjiao acupuncture in the treatment of dysphagia after ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2022, 26(20): 30-34. DOI: 10.7619/jcmp.20221050
    [3]BAI Xue, LI Bing, LI Hua, GONG Qiwei, FENG Ling. Effect of early swallowing and feeding intervention on dysphagia and quality of life in postoperative patients with tongue cancer[J]. Journal of Clinical Medicine in Practice, 2022, 26(12): 46-50. DOI: 10.7619/jcmp.20220199
    [4]DAI Suyun, XIANG Wenhai, CUI Lisheng, OUYANG Yuchen, DING Jie, FENG Huiping, DONG Jiahao. Oral sensation training in patients with dysphagia and salivation after stroke[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 6-10. DOI: 10.7619/jcmp.20213872
    [5]XU Jiehui, HAO Zhina, PIAO Jingjing, GU Yanmei. Effect of timing acupoint stimulation for dysphagia patients after stroke[J]. Journal of Clinical Medicine in Practice, 2021, 25(17): 70-75. DOI: 10.7619/jcmp.20211546
    [6]HU Yue. Rehabilitation nursing of traditional Chinese medicine in patients with dysphagia after stroke[J]. Journal of Clinical Medicine in Practice, 2020, 24(11): 78-81. DOI: 10.7619/jcmp.202011022
    [7]CHEN Xinxing, TIAN Ling. Timing selection of acupuncture and rehabilitation training for patients with dysphagia after stroke[J]. Journal of Clinical Medicine in Practice, 2020, 24(6): 123-125. DOI: 10.7619/jcmp.202006034
    [8]LIU Guoju, DING Yun, CHENG Yuefeng, LIANG Caihong. Effect of drinking water test combined with swallowing training for the treatment of cerebral infarction patients with dysphagia[J]. Journal of Clinical Medicine in Practice, 2018, (2): 5-8. DOI: 10.7619/jcmp.201802002
    [9]ZHAO Feili, ZHANG Chunni. Effect of time rehabilitation nursing on functional rehabilitation of cerebral infarction patients with dysphagia[J]. Journal of Clinical Medicine in Practice, 2016, (6): 10-12. DOI: 10.7619/jcmp.201606004
    [10]Ayshemgul·Shadr, ZHAO Jie, YANG Yunxin. Effect observation of different approaches in the treatment of dysphagia in patients with cerebral stroke[J]. Journal of Clinical Medicine in Practice, 2014, (18): 72-74. DOI: 10.7619/jcmp.201418023

  • Cited by

    Periodical cited type(1)

    1. 万姜维，成东茹，王涛，高萍. 血清乳酸脱氢酶、β_2微球蛋白、铁蛋白联合改良WHO预后积分系统预测骨髓增生异常综合征预后不良的价值. 实用临床医药杂志. 2024(05): 79-84 . 本站查看

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (136) PDF downloads (5) Cited by(1)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return