Correlations of serum cyclic adenosine monophosphate-responsive element binding protein regulator of transcription coactivator 3 and oxidative stress indicators with carotid atherosclerosis in patients with coronary heart disease

LI Xin; CHENG Guojie; LIU Jia; WANG Wenbin

doi:10.7619/jcmp.20233748

Journal of Clinical Medicine in Practice > 2024 > 28(15): 31-35. > DOI: 10.7619/jcmp.20233748

LI Xin, CHENG Guojie, LIU Jia, WANG Wenbin. Correlations of serum cyclic adenosine monophosphate-responsive element binding protein regulator of transcription coactivator 3 and oxidative stress indicators with carotid atherosclerosis in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2024, 28(15): 31-35. DOI: 10.7619/jcmp.20233748

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Correlations of serum cyclic adenosine monophosphate-responsive element binding protein regulator of transcription coactivator 3 and oxidative stress indicators with carotid atherosclerosis in patients with coronary heart disease

1.
Department of Cardiology, Daxing District People's Hospital in Beijing, Beijing, 102600
2.
Department of Ultrasound, Daxing District People's Hospital in Beijing, Beijing, 102600

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Received Date: November 20, 2023
Revised Date: May 02, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of serum cyclic adenosine monophosphate-responsive element binding protein regulator of transcription coactivator 3 (CRTC3) and oxidative stress indicators with carotid atherosclerosis in patients with coronary heart disease (CHD).
Methods
A total of 154 CHD patients in the hospital from June 2021 to June 2023 were selected as study group and divided into mild, moderate, and severe atherosclerosis groups based on the degree of carotid atherosclerosis; another 154 healthy individuals with physical examinations in the same period were selected as control group. Pearson method was used to analyze the correlations of serum CRTC3 and oxidative stress indicators with carotid atherosclerosis indicators.
Results
Serum CRTC3 and malondialdehyde (MDA), carotid plaque area and intima-media thickness (IMT) in the study group were significantly higher than those in the control group, while the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were significantly lower than those in the control group (P < 0.05). In the mild, moderate and severe atherosclerosis groups, serum CRTC3 and MDA levels, carotid plaque area, and IMT significantly gradually increased, while SOD and GSH-Px levels significantly gradually decreased (P < 0.05). Pearson correlation analysis showed that serum CRTC3 and MDA levels were positively correlated with carotid plaque area and IMT (P < 0.05), while SOD and GSH-Px were negatively correlated with carotid plaque area and IMT (P < 0.05). The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) for the combined diagnosis of severe carotid atherosclerosis by CRTC3, SOD, MDA and GSH-Px was 0.990 (95%CI, 0.982 to 0.998), with a sensitivity of 96.27% and a specificity of 76.28%. The diagnostic value of the combined application of these four indicators was significantly higher than that of each indicator alone (Z_{combined-CRTC3}=2.723, Z_combined-SOD=2.698, Z_combined-MDA=2.673, Z_{combined-GSH-Px}=2.803, P < 0.05).
Conclusion
The serum levels of CRTC3 and MDA are significantly increased while SOD and GSH-Px levels are significantly decreased in CHD patients. Both serum CRTC3 and oxidative stress levels are closely related to carotid atherosclerosis.

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References (19)

References

[1]	赵桂琴, 狄文娟, 郭振峰. 冠心病规范化二级预防的临床结果分析[J]. 医学综述, 2018, 24(21): 4350-4354. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZS201821038.htm
[2]	YANG S, HOSHINO M, KOO B K, et al. Relationship of plaque features at coronary CT to coronary hemodynamics and cardiovascular events[J]. Radiology, 2022, 305(3): 578-587. doi: 10.1148/radiol.213271
[3]	徐景华, 李彩琴. 基于颈动脉超声评估颈动脉粥样硬化易损斑块及与血清炎性因子、氧化应激水平的相关性分析[J]. 当代医学, 2020, 26(16): 60-63. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI202016026.htm
[4]	LIU J Q, YOU W J, XU Z Y, et al. Rapid Communication: Porcine CRTC3 gene clone, expression pattern, and its regulatory role in intestinal epithelial cells[J]. J Anim Sci, 2018, 96(7): 2622-2628. doi: 10.1093/jas/sky205
[5]	武强, 刘梦, 柯文才, 等. 2型糖尿病及腹型肥胖患者血清CRTC3水平与胰岛素抵抗的相关性研究[J]. 中华内分泌代谢杂志, 2019, 35(9): 761-764. https://www.cnki.com.cn/Article/CJFDTOTAL-FBMZ201902012.htm
[6]	孙惠娴, 沈茜煜, 张康振, 等. 老年冠心病患者血清视黄醇结合蛋白4水平与氧化应激和颈动脉粥样硬化的关系研究[J]. 中国心血管病研究, 2019, 17(7): 607-610. https://www.cnki.com.cn/Article/CJFDTOTAL-XXGZ201907009.htm
[7]	李波, 付世全, 陈青梅, 等. 血清内脂素水平与药物洗脱支架内再狭窄的相关性研究[J]. 中国循证心血管医学杂志, 2018, 10(1): 72-75. https://www.cnki.com.cn/Article/CJFDTOTAL-PZXX201801019.htm
[8]	中华医学会心血管病学分会介入心脏病学组, 中华医学会心血管病学分会动脉粥样硬化与冠心病学组, 中国医师协会心血管内科医师分会血栓防治专业委员会, 等. 稳定性冠心病诊断与治疗指南[J]. 中华心血管病杂志, 2018, 46(9): 680-694. https://www.cnki.com.cn/Article/CJFDTOTAL-XXFZ201902001.htm
[9]	丛辉, 储海丹, 景蓉蓉, 等. 冠状动脉粥样硬化性心脏病患者血浆的miR-125b-5p水平与病变程度相关性初探[J]. 中华检验医学杂志, 2017, 40(5): 396-399.
[10]	翟世杰, 顾贝贝. 血浆Hcy、hs-CRP水平与冠心病患者PCI术后不良事件及预后的相关性研究[J]. 中国科技期刊数据库医药, 2022, 8(5): 43-46.
[11]	JUAN-SALVADORES P, JIMÉNEZ DÍAZ V A, RODRÍGUEZ GONZÁLEZ DE ARAUJO A, et al. Clinical features and long-term outcomes in very young patients with myocardial infarction with non-obstructive coronary arteries[J]. J Interv Cardiol, 2022, 2022: 9584527.
[12]	王娟, 刘志云, 丁宏胜, 等. 冠状动脉粥样硬化性心脏病患者小而密低密度脂蛋白、脂蛋白相关磷脂酶A2和组织蛋白酶S水平与颈动脉粥样硬化的相关性[J]. 中华高血压杂志, 2020, 28(6): 572-575. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ202006023.htm
[13]	YOON Y S, TSAI W W, VAN DE VELDE S, et al. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis[J]. Proc Natl Acad Sci U S A, 2018, 115(23): E5289-E5297.
[14]	XU Z Y, LIU J Q, YOU W J, et al. Cold exposure induces nuclear translocation of CRTC3 in brown adipose tissue[J]. J Cell Biochem, 2019, 120(6): 9138-9146. doi: 10.1002/jcb.28189
[15]	LIU J Q, WANG L Y, CHEN W T, et al. CRTC3 regulates the lipid metabolism and adipogenic differentiation of porcine intramuscular and subcutaneous adipocytes by activating the calcium pathway[J]. J Agric Food Chem, 2021, 69(25): 7243-7255. doi: 10.1021/acs.jafc.1c02021
[16]	LIU J Q, XU Z Y, WU W C, et al. Regulation role of CRTC3 in skeletal muscle and adipose tissue[J]. J Cell Physiol, 2018, 233(2): 818-821. doi: 10.1002/jcp.25917
[17]	刘秀娟, 许洪梅. 妊娠期糖尿病孕妇血清CRTC3水平及与糖脂代谢和妊娠结局的关系[J]. 中国妇幼保健, 2022, 37(6): 1002-1004. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202206011.htm
[18]	LI L M, YANG X B. The essential element manganese, oxidative stress, and metabolic diseases: links and interactions[J]. Oxid Med Cell Longev, 2018, 2018: 7580707. doi: 10.1155/2018/7580707
[19]	MAILLOUX R J. Mitochondrial antioxidants and the maintenance of cellular hydrogen peroxide levels[J]. Oxid Med Cell Longev, 2018, 2018: 7857251. doi: 10.1155/2018/7857251

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Correlations of serum cyclic adenosine monophosphate-responsive element binding protein regulator of transcription coactivator 3 and oxidative stress indicators with carotid atherosclerosis in patients with coronary heart disease