Clinical efficacy of Huazhuo Tongqing Decoction in treating chronic atrophic gastritis with internal accumulation of turbidity and poison

Objective To explore the clinical effect of Huazhuo Tongqing Yin in treating chronic atrophic gastritis (CAG) with internal accumulation of turbidity and poison.

Methods A total of 159 patients with CAG were randomly divided into traditional Chinese medicine group, western medicine group and control group, and were given Huazhuo Tongqing Decoction, rabeprazole sodium enteric-coated tablets and morodan, respectively. Clinical efficacy, TCM syndromes, pathological changes, 36-item Short-form Health Status Survey(SF-36) score and serum gastrin-17 (G-17) and prostaglandin E₂ (PGE2) before and after treatment were compared.

Results The total effective rate was 92.45% in Chinese medicine group, 62.26% in western medicine group and 66.04% in control group. After three months of treatment, the scores of epigastric pain, gastric distension and discomfort, acid regurgitation and heartburn, belching, and stool stickiness in the three groups were all lower than those before treatment, and the scores of epigastric pain, gastric distension and discomfort, acid regurgitation and heartburn, belching, and sticky stool in the traditional Chinese medicine group were lower than those in the control group andthe western medicine group (P < 0.05). The SF-36 scores of the three groups at 1-, 2-, 3-month improved after treatment, and the SF-36 score of the traditional Chinese medicine group was higher than that of the control group and the western medicine group (P < 0.05). During follow-up, the SF-36 score of the traditional Chinese medicine group was still higher than those of the control group and the western medicine group (P < 0.05). After treatment, the serum levels of G-17 and PGE2 in the three groups were higher thanthose before treatment, and were higher in the traditional Chinese medicine group than those in the western medicine group and the control group (P < 0.05). No adverse reactions occurred in any of the three groups during treatment.

Conclusion Huazhuo Tongqing Decoction can alleviate the symptoms of CAG, improve the pathological state and the quality of life.