Relationships of serum levels of B-type natriuretic peptide and insulin-like growth factor binding protein-3 with atrial fibrillation in patients with non-alcoholic fatty liver disease

LI Yan; HAN Li

doi:10.7619/jcmp.20234044

Journal of Clinical Medicine in Practice > 2024 > 28(7): 101-105,109. > DOI: 10.7619/jcmp.20234044

LI Yan, HAN Li. Relationships of serum levels of B-type natriuretic peptide and insulin-like growth factor binding protein-3 with atrial fibrillation in patients with non-alcoholic fatty liver disease[J]. Journal of Clinical Medicine in Practice, 2024, 28(7): 101-105,109. DOI: 10.7619/jcmp.20234044

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Relationships of serum levels of B-type natriuretic peptide and insulin-like growth factor binding protein-3 with atrial fibrillation in patients with non-alcoholic fatty liver disease

LI Yan,
HAN Li

Department of Laboratory Medicine, the Fourth People's Hospital of Nanchong City of Sichuan Province, Nanchong, Sichuan, 637000

More Information

Received Date: December 12, 2023
Revised Date: January 21, 2024
Available Online: April 21, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the relationships of serum levels of B-type natriuretic peptide (BNP) and insulin-like growth factor binding protein-3 (IGFBP-3) with the occurrence of atrial fibrillation in patients with non-alcoholic fatty liver disease (NAFLD).
Methods
A total of 105 patients with NAFLD were included in observation group, and another 105 healthy individuals were included in control group. Clinical data of the patients were collected, and serum levels of BNP and IGFBP-3 were compared between the two groups. The influencing factors of atrial fibrillation in patients with NAFLD were analyzed, and the interactive effects of serum BNP and IGFBP-3 on the risk of atrial fibrillation in patients with NAFLD were explored. The predictive value of serum BNP and IGFBP-3 levels for atrial fibrillation in patients with NAFLD was also evaluated.
Results
The serum levels of BNP and IGFBP-3 in the observation group were significantly higher than those in the control group (P<0.05). Among the patients in the observation group, 30 cases developed atrial fibrillation within one year. The levels of body mass index (BMI), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), BNP, and IGFBP-3 were higher in patients with atrial fibrillation compared to those without, while the level of high-density lipoprotein cholesterol (HDL-C) was lower (P<0.05). BMI, TC, TG, HDL-C, LDL-C, BNP, and IGFBP-3 were all influencing factors for the occurrence of atrial fibrillation in patients with NAFLD (P<0.05). There was an interaction between BNP and IGFBP-3, 50.47%of the risk of atrial fibrillation in patients with NAFLD was attributed to this interaction. The area under the curve for the combined prediction of serum BNP and IGFBP-3 was 0.928, which was significantly larger than the AUC of 0.753 and 0.821 for the individual predictions of BNP and IGFBP-3, respectively (P<0.05).
Conclusion
The expression levels of BNP and IGFBP-3 in the serum of patients with NAFLD are significantly elevated, and the combined use of these markers can effectively predict the occurrence of atrial fibrillation in these patients.

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References (20)

References

[1]	霍艳蓓, 白亚娜, 张德生, 等. 金昌队列人群非酒精性脂肪肝发病的影响因素分析[J]. 中华流行病学杂志, 2021, 42(3): 493-498. doi: 10.3760/cma.j.cn112338-20200428-00668
[2]	杨燕, 姚艺璇, 洪秀韬, 等. 应用胰岛素抵抗替代指标评估2型糖尿病患者非酒精性脂肪肝及进展性肝纤维化的价值[J]. 中华内分泌代谢杂志, 2021, 37(4): 281-287. doi: 10.3760/cma.j.cn311282-20201117-00761
[3]	水明明, 石明, 李艳萍, 等. 体检人群非酒精性脂肪性肝病与心血管疾病发病风险的关联性研究[J]. 中国医院统计, 2022, 29(2): 81-86. https://www.cnki.com.cn/Article/CJFDTOTAL-JTYY202202001.htm
[4]	NISHIKIMI T, NAKAGAWA Y. Potential pitfalls when interpreting plasma BNP levels in heart failure practice[J]. J Cardiol, 2021, 78(4): 269-274. doi: 10.1016/j.jjcc.2021.05.003
[5]	MARTÍN A I, PRIEGO T, MORENO-RUPEREZ Á, et al. IGF-1 and IGFBP-3 in inflammatory Cachexia[J]. Int J Mol Sci, 2021, 22(17): 9469. doi: 10.3390/ijms22179469
[6]	卢建国, 於龙. 肝纤维化对非酒精性脂肪性肝病患者发生心血管疾病的影响[J]. 临床消化病杂志, 2023, 35(1): 38-41. https://www.cnki.com.cn/Article/CJFDTOTAL-LCXH202301009.htm
[7]	FILIPPATOS T D, ALEXAKIS K, MAVRIKAKI V, et al. Nonalcoholic fatty pancreas disease: role in metabolic syndrome, "prediabetes" diabetes and atherosclerosis[J]. Dig Dis Sci, 2022, 67(1): 26-41. doi: 10.1007/s10620-021-06824-7
[8]	LEE Y, KIM B R, KANG G H, et al. The effects of PPAR agonists on atherosclerosis and nonalcoholic fatty liver disease in ApoE-/-FXR-/- mice[J]. Endocrinol Metab, 2021, 36(6): 1243-1253. doi: 10.3803/EnM.2021.1100
[9]	李颖. 非瓣膜性心房颤动患者发生心力衰竭的影响因素[J]. 中国民康医学, 2023, 35(3): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202303001.htm
[10]	路晓茅, 邸阜生. 2型糖尿病合并非酒精性脂肪肝患者发生心房纤颤的危险因素分析[J]. 天津医药, 2017, 45(3): 285-288. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ201703015.htm
[11]	NISHIKIMI T, NAKAGAWA Y. B-type natriuretic peptide (BNP) revisited-is BNP still a biomarker for heart failure in the angiotensin receptor/neprilysin inhibitor era[J]. Biology, 2022, 11(7): 1034. doi: 10.3390/biology11071034
[12]	张素媛, 王红坡. 肝硬化患者血浆BNP水平与ALB、TBil及PT的相关性分析[J]. 实验与检验医学, 2019, 37(4): 667-668, 671. doi: 10.3969/j.issn.1674-1129.2019.04.034
[13]	宿慧, 吴静, 刘红, 等. 肝硬化患者血清学和超声心动图检查对肝硬化心肌病的早期诊断价值[J]. 中国临床医生杂志, 2018, 46(8): 921-923. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS201808015.htm
[14]	何胜男. 三维斑点追踪成像技术评估年轻成人非酒精性脂肪肝对左心室功能的影响[J]. 影像研究与医学应用, 2022, 6(10): 106-108. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYY202210035.htm
[15]	丛方远, 薛倩, 邓利华, 等. 非酒精性脂肪性肝病与左心室早期舒张功能不全的相关性研究[J]. 中国全科医学, 2022, 25(26): 3290-3297, 3307. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202226013.htm
[16]	STUARD W L, GUNER M K, ROBERTSON D M. IGFBP-3 regulates mitochondrial hyperfusion and metabolic activity in ocular surface epithelia during hyperosmolar stress[J]. Int J Mol Sci, 2022, 23(7): 4066.
[17]	KHASHALI H A, WAREHAM J, RAY R, et al. Opposing roles of IGFBP-3 and heparanase in regulating A549 lung cancer cell survival[J]. Cells, 2022, 11(22): 3533.
[18]	邹琳, 李铁岩, 钱丽娟, 等. GH/IGF1轴对非酒精性脂肪肝病脂代谢的影响及可能机制研究[J]. 中国现代医学杂志, 2019, 29(3): 15-22. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY201903003.htm
[19]	BINAY C, SIMSEK E, YILDIRIM A, et al. Growth hormone and the risk of atherosclerosis in growth hormone-deficient children[J]. Growth Horm IGF Res, 2015, 25(6): 294-297.
[20]	孙琴, 范旭虹. 肥胖型多囊卵巢综合征患者血清miR-124、IGFBP-3与糖脂代谢[J]. 中国计划生育学杂志, 2021, 29(6): 1258-1262. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202106043.htm

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Relationships of serum levels of B-type natriuretic peptide and insulin-like growth factor binding protein-3 with atrial fibrillation in patients with non-alcoholic fatty liver disease