Advance Search
ZHANG Lanfang, CHEN Xu, KUAI Jun, QIN Lei, YANG Yan, CHANG Tingmin. Effect of tegafur, gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones, matrix metalloproteinase-2 and matrix metalloproteinase-9 in elderly patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(12): 57-60, 65. DOI: 10.7619/jcmp.20241047
Citation: ZHANG Lanfang, CHEN Xu, KUAI Jun, QIN Lei, YANG Yan, CHANG Tingmin. Effect of tegafur, gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones, matrix metalloproteinase-2 and matrix metalloproteinase-9 in elderly patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(12): 57-60, 65. DOI: 10.7619/jcmp.20241047
shu

Effect of tegafur, gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones, matrix metalloproteinase-2 and matrix metalloproteinase-9 in elderly patients with gastric cancer

  • 1.

    the Second Ward of Gastroenterology Department, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453100

  • 2.

    the Third Ward of Gastroenterology Department, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 453100

More Information
  • Received Date: March 12, 2024
  • Revised Date: April 25, 2024
  • Available Online: June 28, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the effects of tegafur, gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in elderly patients with gastric cancer.

    Methods 

    A total of 128 elderly patients with gastric cancer were selected as the study subjects and randomly divided into control group (n=64) and observation group (n=64). The control group was treated with tegafur, gimeracil and oteracil potassium, while the observation group received tegafur, gimeracil and oteracil potassium combined with oxaliplatin. Gastric motility-related hormones [motilin (MTL) and vasoactive intestinal peptide (VIP)], MMP-2, MMP-9, tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and carbohydrate antigen 19-9 (CA19-9)], clinical efficacy and occurrence of adverse reactions were observed in both groups. The correlations of gastric motility-related hormones with the levels of MMP-2, MMP-9 and tumor markers were analyzed.

    Results 

    After treatment, MTL levels in both groups were significantly lower, while VIP levels were significantly higher compared to before treatment. Additionally, the observation group had significantly lower MTL and higher VIP levels compared to the control group (P < 0.05). After treatment, the levels of MMP-2, MMP-9, CEA, CA125 and CA19-9 were significantly reduced in both groups compared to pretreatment levels, with the observation group showing significantly lower levels than the control group (P < 0.05). The total effective rate in the observation group was 70.31%, which was significantly higher than the 53.13% in the control group (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). A negative correlation was observed between MTL and MMP-2, MMP-9, CEA, CA125 as well as CA19-9 (P < 0.05), while VIP showed a positive correlation with MMP-2, MMP-9, CEA, CA125 and CA19-9 (P < 0.05).

    Conclusion 

    The combination of tegafur, gimeracil and oteracil potassium and oxaliplatin is effective and safe for the treatment of elderly patients with gastric cancer. MTL, VIP, MMP-2, MMP-9, CEA, CA125 and CA19-9 are interrelated in the development of gastric cancer in elderly patients.

    • FullText(HTML)
    • References (18)
  • [1]
    DIAS A R, PEREIRA M A, RAMOS M F K P, et al. Gastrectomy for elderly gastric cancer patients: a propensity score-matching analysis[J]. J Surg Oncol, 2022, 126(1): 108-115. doi: 10.1002/jso.26850
    [2]
    NISHIBEPPU K, SAKURAMOTO S, MATSUI K, et al. Dismal prognosis of elderly gastric cancer patients who underwent gastrectomy with American Society of Anesthesiologists (ASA)3[J]. Langenbecks Arch Surg, 2022, 407(8): 3413-3421. doi: 10.1007/s00423-022-02672-9
    [3]
    NISHI M, WADA, YOSHIKAWA K, et al. Prognostic impact of frailty after gastrectomy in elderly gastric cancer patients[J]. J Med Invest, 2023, 70(3. 4): 423-429.
    [4]
    IWASAKI H, HARAGUCHI E, IHASHI T, et al. Risk factor of sarcopenia after gastrectomy in elderly patients with gastric cancer[J]. Anticancer Res, 2023, 43(9): 4207-4212. doi: 10.21873/anticanres.16612
    [5]
    FUJIMOTO D, TANIGUCHI K, TAKASHIMA J, et al. Validity and safety of laparoscopic gastrectomy with D1+lymphadenectomy for very elderly advanced gastric cancer patients; retrospective cohort study[J]. Jpn J Clin Oncol, 2022, 52(11): 1282-1288.
    [6]
    RATHI R, KUSHWAHA R, GOYAL A, et al. Oxaliplatin-flavone pharmaceutical co-crystal-CN111205332A: patent spotlight[J]. Pharm Pat Anal, 2022, 11(5): 147-154. doi: 10.4155/ppa-2022-0011
    [7]
    丁秀敏. 奥沙利铂联合替吉奥在胃癌患者中的临床效果观察[J]. 中国冶金工业医学杂志, 2023, 40(1): 125. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYJ202301118.htm
    [8]
    OTSUKA R, HAYASHI H, UESATO M, et al. Inflammatory and nutritional indices as prognostic markers in elderly patients with gastric cancer[J]. Anticancer Res, 2023, 43(11): 5261-5267. doi: 10.21873/anticanres.16728
    [9]
    贝云枫, 何振华, 张炼. 加味小陷胸汤联合替吉奥与奥沙利铂化疗方案治疗胃癌的疗效分析及对血清胃蛋白酶原、外周血循环肿瘤细胞的影响[J]. 中华中医药学刊, 2023, 41(6): 255-258. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202306055.htm
    [10]
    田红旭, 陈希, 牛磊萍, 等. 替吉奥联合奥沙利铂治疗中晚期老年胃癌的疗效及对组织中FOXP1和Ki67表达的影响[J]. 实用癌症杂志, 2022, 37(2): 296-299, 304. https://www.cnki.com.cn/Article/CJFDTOTAL-SYAZ202202031.htm
    [11]
    TENG C, COHEN J, EGGER S, et al. Systematic review of long-term chemotherapy-induced peripheral neuropathy (CIPN) following adjuvant oxaliplatin for colorectal cancer[J]. Support Care Cancer, 2022, 30(1): 33-47. doi: 10.1007/s00520-021-06502-4
    [12]
    YOKOYAMA S, NAKAGAWA C, HOSOMI K. Treatment strategy of oxaliplatin-induced peripheral neuropathy: a retrospective, nationwide study[J]. Support Care Cancer, 2022, 30(2): 1765-1773. doi: 10.1007/s00520-021-06585-z
    [13]
    LIU X, WENISCH D, BARTH M C, et al. Novel oxaliplatin (Ⅳ) complexes conjugated with ligands bearing pendant 1, 2-dithiolane/1, 2-diselenolane/cyclopentyl motifs[J]. Dalton Trans, 2022, 51(44): 16824-16835. doi: 10.1039/D2DT02217F
    [14]
    YAZAKI T, KAWASHIMA K, ISHIMURA N, et al. Oxaliplatin-related portal hypertension complicated with esophageal varices and refractory massive ascites[J]. Intern Med, 2022, 61(21): 3225-3231. doi: 10.2169/internalmedicine.9266-21
    [15]
    SHI C J, XUE Z H, ZENG W Q, et al. LncRNA-NEF suppressed oxaliplatin resistance and epithelial-mesenchymal transition in colorectal cancer through epigenetically inactivating MEK/ERK signaling[J]. Cancer Gene Ther, 2023, 30(6): 855-865. doi: 10.1038/s41417-023-00595-1
    [16]
    王长娟, 孟宪梅, 江振宇, 等. MMP-2、MMP-9及CD133对胃肠神经内分泌肿瘤患者临床预后的影响[J]. 胃肠病学和肝病学杂志, 2023, 32(7): 742-746. https://www.cnki.com.cn/Article/CJFDTOTAL-WCBX202307005.htm
    [17]
    PIGG H C, YGLESIAS M V, SUTTON E C, et al. Time-dependent studies of oxaliplatin and other nucleolar stress-inducing Pt (Ⅱ) derivatives[J]. ACS Chem Biol, 2022, 17(8): 2262-2271. doi: 10.1021/acschembio.2c00399
    [18]
    ALONSO MARTINEZ S, SEGAL N H, CERCEK A, et al. Simplified graded infusion strategy for mitigation of oxaliplatin hypersensitivity[J]. Clin Colorectal Cancer, 2022, 21(2): 149-153. doi: 10.1016/j.clcc.2022.01.006
    • Related Articles

  • Related Articles

    [1]SONG Huahua, ZHU Ronghua, SHI Li. Correlations of serum levels of brain-derived neurotrophic factor, malondialdehyde, endothelin-1 and heat shock protein 70 with cognitive dysfunction in patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Clinical Medicine in Practice, 2025, 29(3): 70-74. DOI: 10.7619/jcmp.20242760
    [2]SUN Qin, ZHANG Wen, XU Mengyuan, XU Suqing, ZHAO Haihe, JIN Minli. Effect of four traditional Chinese drugs for reinforcing kidney combined with Tongqiao Huoxue Decoction on serum neurotransmitters and neurological function in patients with post-stroke cognitive impairment[J]. Journal of Clinical Medicine in Practice, 2025, 29(1): 89-93. DOI: 10.7619/jcmp.20242642
    [3]SUN Yan, WANG Xia, HE Fengying, NIU Meiyan, YU Ruiping, ZHANG Airong. Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 80-84. DOI: 10.7619/jcmp.20221894
    [4]ZHONG Yunian, ZHAO Yilin, XIAO Wenhuan, YANG Xiang, XU Ying. Relationships of cognitive function with inflammatory factors and glial cell line-derived neurotrophic factor in patients with bipolar disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(6): 58-62. DOI: 10.7619/jcmp.20213016
    [5]WANG Jing, ZHAO Yilin, XIAO Wenhuan, WU Hui. Comparison in hematological inflammatory markers and brain-derived neurotrophic factor in patients with schizophrenia and those with bipolar disorder[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 74-77. DOI: 10.7619/jcmp.20212571
    [6]TAN Sanyang, HUANG Hai, LIN Zhangping. Predictive value of umbilical vein blood brain-derived neurotrophic factor level for brain injury of neonates delivered by the pregnant with gestational diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2021, 25(6): 89-92. DOI: 10.7619/jcmp.20201406
    [7]PAN Xinming, HU Xuefeng, WEN Lu, HU Xiuxiu, ZHANG Xiaobin. Effect of atypical antipsychotics on glial cell line-derived neurotrophic factor levels in schizophrenia patients[J]. Journal of Clinical Medicine in Practice, 2017, (21): 12-14,18. DOI: 10.7619/jcmp.201721003
    [8]DING Zhaosheng, ZHOU Fang, LIN Maming, WANG Yun. Influence and clinical effect of fluoxetine on the level of serum brain-derived neurotrophic factor in patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2012, (24): 17-19.
    [9]LIU Jin-wen, ZHANG Xiao-bin, ZHOU Hong-hui, ZHANG Yu-mei. Study of the serum levels of brain- derived neurotrophic factor and glial cell line- derived neurotrophic factor in patients with recurrent depression[J]. Journal of Clinical Medicine in Practice, 2012, (9): 29-31. DOI: 10.3969/j.issn.1672-2353.2012.09.010
    [10]CAI Yi-yun, SHI Shen-xun, XU San-rong, SUN Da-yu. THE IMPACT OF CHRONIC STRESS ON MONOAMINE NEUROTRANSMITTERS IN CSF OF RATS[J]. Journal of Clinical Medicine in Practice, 2005, (1): 2-4. DOI: 10.3969/j.issn.1672-2353.2005.01.002

  • Cited by

    Periodical cited type(6)

    1. 孟凯. 电视胸腔镜辅助环抱器治疗胸部外伤合并肋骨骨折患者的临床效果观察. 大医生. 2025(04): 23-25 .
    2. 王晓康. 肋骨接骨板置入内固定术对肋骨骨折安全性及疼痛的影响. 中国医药指南. 2024(04): 14-16 .
    3. 成刚，王长兴. 基于胸腔镜的复位内固定术治疗老年肋骨骨折患者的临床疗效研究. 实用临床医药杂志. 2024(05): 89-93 . 本站查看
    4. 彭亮，郭剑，查波辉，吴珊燕，舒华宝，吴胜华，杨子熠，王小娟. 急诊创伤性血气胸在床边超声引导下精准化穿刺置管引流术的治疗效果. 检验医学与临床. 2024(09): 1245-1249 .
    5. 冉隆强，李勇，贾萌. 胸腔镜辅助内固定术对多发肋骨骨折合并胸部创伤患者肺功能及预后的影响. 中国医刊. 2023(05): 517-520 .
    6. 周攀，吴中权，朱杰，舒圣，程玲玲. 胸腔镜微创手术和快速康复治疗严重胸部碾轧伤1例. 中国医药. 2023(08): 1255-1258 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by(6)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return