Research progress on macrophage-like cells at vitreoretinal interface

CHEN Ziqing; WANG Ke; ZOU Wenjun

doi:10.7619/jcmp.20241091

Journal of Clinical Medicine in Practice > 2024 > 28(11): 139-143. > DOI: 10.7619/jcmp.20241091

CHEN Ziqing, WANG Ke, ZOU Wenjun. Research progress on macrophage-like cells at vitreoretinal interface[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 139-143. DOI: 10.7619/jcmp.20241091

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Research progress on macrophage-like cells at vitreoretinal interface

CHEN Ziqing¹,
WANG Ke²,
ZOU Wenjun^{1, 3, ,}

1.
Department of Ophthalmology, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, 214002
2.
Functional Protein Research Group of Jiangsu Institute of Atomic Medicine, Wuxi, Jiangsu, 214063
3.
Department of Ophthalmology, Medical Center Affiliated to Jiangnan University, Wuxi, Jiangsu, 214002

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Received Date: March 13, 2024
Revised Date: May 10, 2024
Available Online: June 17, 2024

Graphical Abstract

Abstract

Abstract

Macrophage-like cells (MLCs) are a heterogeneous group of cells with immune functions, mainly including microglia, vitreous cells, and plasma monocytes-macrophages. Under physiological conditions, MLCs participate in maintaining the homeostasis of the retina, and under pathological conditions, they participate in inflammatory lesions of the retina, such as diabetic retinopathy, retinal vein occlusion, and uveitis. In 2020, researcher represented by CASTANOS MV and others firstly used clinical optical coherence tomography (OCT) instruments to visualize MLCs at the vitreoretinal interface, and since then, more and more research teams have applied it to the study of various retinal and choroidal inflammatory diseases. This study elaborated on the general characteristics of MLCs and their research progress in various retinal and choroidal inflammatory diseases.
- microglia,
- optical coherence tomography,
- macrophage-like cells,
- diabetic retinopathy,
- retinal vein occlusion,
- uveitis

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References (28)

References

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