A Mendelian randomization study on the causal association between social stress and tinnitus onset

ZHU Jingxin; MA Rui; CHAI Zekun; DONG Yuran; WANG Le

doi:10.7619/jcmp.20242091

Journal of Clinical Medicine in Practice > 2024 > 28(19): 55-59, 67. > DOI: 10.7619/jcmp.20242091

ZHU Jingxin, MA Rui, CHAI Zekun, DONG Yuran, WANG Le. A Mendelian randomization study on the causal association between social stress and tinnitus onset[J]. Journal of Clinical Medicine in Practice, 2024, 28(19): 55-59, 67. DOI: 10.7619/jcmp.20242091

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A Mendelian randomization study on the causal association between social stress and tinnitus onset

1.
the Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing, 100078
2.
the First Department of Encephalopathy, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, 100078

More Information

Received Date: May 19, 2024
Revised Date: July 11, 2024

Graphical Abstract

Abstract

Abstract

Objective
To explore the causal relationship between social stress and tinnitus onset using a two-sample Mendelian randomization approach.
Methods
Genetic data pertaining to social stress and tinnitus were extracted from genome-wide association studies (GWAS) databases. Single nucleotide polymorphisms (SNP) that were independent and strongly correlated with social stress were selected as instrumental variables, with tinnitus serving as the outcome variable. Mendelian randomization analyses were performed using inverse-variance weighted (IVW) method, weighted median method, and Mendelian randomization-Egger regression. The intercept term from Mendelian randomization-Egger regression was utilized to assess horizontal pleiotropy, Cochran's Q statistic was employed to evaluate heterogeneity, and leave-one-out analysis was conducted for sensitivity assessment.
Results
The social stress dataset encompassed 459, 742 samples, while the tinnitus dataset comprised 117, 882 samples. A total of 10 SNPs tightly associated with social stress were identified as instrumental variables. The analysis results of random-effects inverse variance weighting (IVW), weighted median method, and Mendelian randomization-Egger regression were similar (OR=1.251, 1.274, 1.438), indicating that social stress was a risk factor for tinnitus, and there was a positive causal effect between them, with no heterogeneity or pleiotropy in the results.
Conclusion
There is a causal relationship between social stress and tinnitus onset, which may offer novel perspectives for the clinical prevention and treatment of tinnitus in the future.
- social stress,
- tinnitus,
- Mendelian randomization,
- causal relationship,
- glutamate,
- N-methyl-D-aspartate receptor

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References (25)

References

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A Mendelian randomization study on the causal association between social stress and tinnitus onset