2014 No. 5
Abstract：
Objective To compare the clinical significance of combined detection of serum carcino-embryonic antigen (CEA),carbohydrate antigens (CA19-9,CA50 and CA72-4)in the di-agnosis of patients with gastric cancer.Methods The levels of serum CEA,CA19-9,CA50 and CA72-4 in patients with gastric cancer (gastric group,n =38),gastritis (gastritis group,n =34) and gastric ulcer (gastric ulcer group,n =37)as well as healthy people (control group,n =36) were detected respectively.Results The levels of sensitivity of CEA,CA19-9,CA50 and CA72-4 were 49.7%,54.1%,38.2% and 41.7% respectively,while the level of sensitivity of combined detection was 79.6%.Conclusion Combined detection of CEA,CA19-9,CA50 and CA72-4 shows a great clinical significance in the diagnosis and efficacy observation of patients with gastric cancer.
Objective To compare the clinical significance of combined detection of serum carcino-embryonic antigen (CEA),carbohydrate antigens (CA19-9,CA50 and CA72-4)in the di-agnosis of patients with gastric cancer.Methods The levels of serum CEA,CA19-9,CA50 and CA72-4 in patients with gastric cancer (gastric group,n =38),gastritis (gastritis group,n =34) and gastric ulcer (gastric ulcer group,n =37)as well as healthy people (control group,n =36) were detected respectively.Results The levels of sensitivity of CEA,CA19-9,CA50 and CA72-4 were 49.7%,54.1%,38.2% and 41.7% respectively,while the level of sensitivity of combined detection was 79.6%.Conclusion Combined detection of CEA,CA19-9,CA50 and CA72-4 shows a great clinical significance in the diagnosis and efficacy observation of patients with gastric cancer.
Abstract：
Obj ective To observe the influence of carotid artery stenting (CAS)on the life quality and cognitive function of patients with severe carotid artery stenosis.Methods 64 carotid artery stenosis patients treated with CAS were collected. Mini -mental state examination (MMSE),activity of daily living scale (ADL),rapid verbal retrieve (RVR),digit span (DS),vi-sual retention test (VRT)and WHOQOL were applied for patients to assess efficacy at the time points of before operation and 3 ,12 months after operation.Results The success rate of CAS was 100%,and no complications such as embolism and internal carotid artery thrombosis were ob-served .The rate of carotid artery stenosis decreased after operation,while the carotid blood flow improved significantly.3 and 12 months after treatment,MMSE,VR and DS scores increased sig-nificantly,and ADL score decreased significantly,and the increased and decreased ranges at the time of 12 months after treatment were significantly larger than those at the time of 3 months after treatment.3 months after treatment,VRT right score and WHOQOL score increased,while VRT wrong score reduced significantly.Conclusion CAS can significantly improve the life quality and cognitive function of patients with carotid artery stenosis,so it is worthy of clinical application and popularization.
Obj ective To observe the influence of carotid artery stenting (CAS)on the life quality and cognitive function of patients with severe carotid artery stenosis.Methods 64 carotid artery stenosis patients treated with CAS were collected. Mini -mental state examination (MMSE),activity of daily living scale (ADL),rapid verbal retrieve (RVR),digit span (DS),vi-sual retention test (VRT)and WHOQOL were applied for patients to assess efficacy at the time points of before operation and 3 ,12 months after operation.Results The success rate of CAS was 100%,and no complications such as embolism and internal carotid artery thrombosis were ob-served .The rate of carotid artery stenosis decreased after operation,while the carotid blood flow improved significantly.3 and 12 months after treatment,MMSE,VR and DS scores increased sig-nificantly,and ADL score decreased significantly,and the increased and decreased ranges at the time of 12 months after treatment were significantly larger than those at the time of 3 months after treatment.3 months after treatment,VRT right score and WHOQOL score increased,while VRT wrong score reduced significantly.Conclusion CAS can significantly improve the life quality and cognitive function of patients with carotid artery stenosis,so it is worthy of clinical application and popularization.
Abstract：
Objective To explore the repair effect of mouse nerve growth factor (mNGF) on the neurological function of hand-foot-and-mouth disease (HFMD)children with central lesion. Methods 86 children with severe HFMD were divided into treatment group and control group ac-cording to the number of hospitalization,43 cases in each group.Both groups were treated with conventional comprehensive treatment for HFMD,while the treatment group was injected with mNGF on the basis of basic treatment.The disappearance time of symptoms associated with nervous system injury,neurological scores before treatment and on the third,seventh days of treatment as well as the levels of while cells and creatine kinase (CK)before and after treatment were compared, and the adverse reactions were observed.Results The disappearance time of vomiting,skittishness, limb shaking,myasthenia and somnolence as well as hospital stay in the treatment group were sig-nificantly shorter than those in the control group.Neurological scores on the third,seventh days of treatment decreased significantly in both groups,and neurological scores in treatment group were significantly lower than control group.After treatment,the levels of white cells and CK decreased significantly in both groups,and the decreased range in treatment group was larger.No obvious ab-normal reactions were observed by liver and kidney examination during treatment.Conclusion For children with HFMD and central lesion,application of mNGFcan effectively promote the repairmen of injured nervous tissue,improve the neurological function and shorten the course of disease.
Objective To explore the repair effect of mouse nerve growth factor (mNGF) on the neurological function of hand-foot-and-mouth disease (HFMD)children with central lesion. Methods 86 children with severe HFMD were divided into treatment group and control group ac-cording to the number of hospitalization,43 cases in each group.Both groups were treated with conventional comprehensive treatment for HFMD,while the treatment group was injected with mNGF on the basis of basic treatment.The disappearance time of symptoms associated with nervous system injury,neurological scores before treatment and on the third,seventh days of treatment as well as the levels of while cells and creatine kinase (CK)before and after treatment were compared, and the adverse reactions were observed.Results The disappearance time of vomiting,skittishness, limb shaking,myasthenia and somnolence as well as hospital stay in the treatment group were sig-nificantly shorter than those in the control group.Neurological scores on the third,seventh days of treatment decreased significantly in both groups,and neurological scores in treatment group were significantly lower than control group.After treatment,the levels of white cells and CK decreased significantly in both groups,and the decreased range in treatment group was larger.No obvious ab-normal reactions were observed by liver and kidney examination during treatment.Conclusion For children with HFMD and central lesion,application of mNGFcan effectively promote the repairmen of injured nervous tissue,improve the neurological function and shorten the course of disease.
Abstract：
Objective To explore the diagnostic value of serum thyroglobulin antibody (TGAb),thyroid microsomal antibody (TMAb)and thyroid peroxidase antibody (TPOAb)in au-toimmune thyroid disease (AITD).Methods 100 patients with thyroid dysfunction were divided into hyperthyroidism group and hypothyroidism group according to the levels of serum triiodothy-ronine (T3),thyroxine (T4)and thyroid stimulating hormone (TSH),50 cases in each group.An-other 50 patients with normal thyroid function were collected and designed as control group.5 mL venous blood was collected,and the serum was separated.The levels of TGAb,TMAb,TPOAb, T3,T4 and TSH were detected by radioimmunoassay in each group,positive rates of TGAb,TMAb and TPOAb were observed,and the serum levels of positive TGAb,TMAb and TPOAb were com-pared among all the groups.Results The positive rate of serum TPOAb was significantly higher than those of TGAb and TMAb in hyperthyroidism group and hypothyroidism group.The positive rates of serum TGAb,TMAb and TPOAb in hyperthyroidism and hypothyroidism groups were sig-nificantly higher than the control group,and those in hypothyroidism group were higher than hy-perthyroidism group.The levels of serum TGAb,TMAb and TPOAb in hyperthyroidism group and hypothyroidism group were significantly higher than the control group,and those in hypothyroidism group were obviously higher than hyperthyroidism group.Conclusion TPOAb shows an important significance in diagnosing AITD,which provides an important evidence for AITD diagnosis, treatment and prognosis.
Objective To explore the diagnostic value of serum thyroglobulin antibody (TGAb),thyroid microsomal antibody (TMAb)and thyroid peroxidase antibody (TPOAb)in au-toimmune thyroid disease (AITD).Methods 100 patients with thyroid dysfunction were divided into hyperthyroidism group and hypothyroidism group according to the levels of serum triiodothy-ronine (T3),thyroxine (T4)and thyroid stimulating hormone (TSH),50 cases in each group.An-other 50 patients with normal thyroid function were collected and designed as control group.5 mL venous blood was collected,and the serum was separated.The levels of TGAb,TMAb,TPOAb, T3,T4 and TSH were detected by radioimmunoassay in each group,positive rates of TGAb,TMAb and TPOAb were observed,and the serum levels of positive TGAb,TMAb and TPOAb were com-pared among all the groups.Results The positive rate of serum TPOAb was significantly higher than those of TGAb and TMAb in hyperthyroidism group and hypothyroidism group.The positive rates of serum TGAb,TMAb and TPOAb in hyperthyroidism and hypothyroidism groups were sig-nificantly higher than the control group,and those in hypothyroidism group were higher than hy-perthyroidism group.The levels of serum TGAb,TMAb and TPOAb in hyperthyroidism group and hypothyroidism group were significantly higher than the control group,and those in hypothyroidism group were obviously higher than hyperthyroidism group.Conclusion TPOAb shows an important significance in diagnosing AITD,which provides an important evidence for AITD diagnosis, treatment and prognosis.
2014, (5): 13-15,37.
DOI: 10.7619/jcmp.201405005
Abstract：
Objective To observe the effect of epidermal growth factor receptor (EGFR)sig-nal transduction inhibitor RG-14260 (RG)alone or combined with mTOR signal transduction inhibitor rapamycin (RA)on the proliferation and expression of decorin (DCN)in Ishikawa cells in vitro. Methods After treated with RG alone or combined with RA for 24 hours,immunohistochemical meth-od was used to detect the expression of proliferating cell nuclear antigens (PCNA).Reverse tran-scriptase-polymerase chain reaction (RT-PCR)and Western blot method were used to detect the ex-pression changes of DCN genes and proteins in cells respectively.Results RG alone or combined with RA were able to decrease the expression rate of positive PCNA cells in Ishikawa cells,promote the ex-pression of DCN genes and proteins,but the efficacy of combined application was more significant. Conclusion Single and combined applications of EGFR and mTOR signal transduction inhibitors can up-regulate the expression of DCN in Ishikawa cells at the levels of genes and proteins,and meanwhile the increased DCN can reinforce the inhibitory effect of signal transduction inhibitors on the cell prolif-eration.
Objective To observe the effect of epidermal growth factor receptor (EGFR)sig-nal transduction inhibitor RG-14260 (RG)alone or combined with mTOR signal transduction inhibitor rapamycin (RA)on the proliferation and expression of decorin (DCN)in Ishikawa cells in vitro. Methods After treated with RG alone or combined with RA for 24 hours,immunohistochemical meth-od was used to detect the expression of proliferating cell nuclear antigens (PCNA).Reverse tran-scriptase-polymerase chain reaction (RT-PCR)and Western blot method were used to detect the ex-pression changes of DCN genes and proteins in cells respectively.Results RG alone or combined with RA were able to decrease the expression rate of positive PCNA cells in Ishikawa cells,promote the ex-pression of DCN genes and proteins,but the efficacy of combined application was more significant. Conclusion Single and combined applications of EGFR and mTOR signal transduction inhibitors can up-regulate the expression of DCN in Ishikawa cells at the levels of genes and proteins,and meanwhile the increased DCN can reinforce the inhibitory effect of signal transduction inhibitors on the cell prolif-eration.
Abstract：
Objective To explore the role of disease activity indexes (DAS)in assessment of early efficacy of rheumatoid arthritis (RA)patients with infliximab (IFX)treatment.Methods 14 patients with moderate and severe activity RA were firstly treated with an intravenous infusion of 200 mg IFX.The levels of the swollen joint count (SJC),tender joint count (TJC),C-reactive protein (CRP),erythrocyte sedimentation rate (ESR),DAS28-CRP,the health assessment questionnaire (HAQ)and rheumatoid factor (RF)were evaluated at 0 hour (baseline),3,6,24 hours after infu-sion and 3,7 and 14 days after IFX infusion.Results SJC,TJC,CRP,ESR,DAS28-CRP,HAQ and RF improved significantly on 14th day,in which TJC reduced 3 days after treatment,SJC and HAQ improved 7 days after treatment,CRP and DAS28-CRP started to decrease 6 hours immediately after IFX infusion.CRP level was the lowest on third day,and then gradually recovered 7 days after treatment,and remained below the baseline level on 14th day.Conclusion As the most sensitive in-dexes reflecting the early efficacy of IFX for RA,both CRP and DAS28-CRP can be used as the pre-dictive factors for IFX early efficacy.
Objective To explore the role of disease activity indexes (DAS)in assessment of early efficacy of rheumatoid arthritis (RA)patients with infliximab (IFX)treatment.Methods 14 patients with moderate and severe activity RA were firstly treated with an intravenous infusion of 200 mg IFX.The levels of the swollen joint count (SJC),tender joint count (TJC),C-reactive protein (CRP),erythrocyte sedimentation rate (ESR),DAS28-CRP,the health assessment questionnaire (HAQ)and rheumatoid factor (RF)were evaluated at 0 hour (baseline),3,6,24 hours after infu-sion and 3,7 and 14 days after IFX infusion.Results SJC,TJC,CRP,ESR,DAS28-CRP,HAQ and RF improved significantly on 14th day,in which TJC reduced 3 days after treatment,SJC and HAQ improved 7 days after treatment,CRP and DAS28-CRP started to decrease 6 hours immediately after IFX infusion.CRP level was the lowest on third day,and then gradually recovered 7 days after treatment,and remained below the baseline level on 14th day.Conclusion As the most sensitive in-dexes reflecting the early efficacy of IFX for RA,both CRP and DAS28-CRP can be used as the pre-dictive factors for IFX early efficacy.
Abstract：
Objective To explore the influence of parenteral nutrition (PN)supportive therapy on the nutritional status and immune function in patients with advanced gastrointestinal tu-mor in peri-chemotherapy period.Methods 90 patients with advanced gastrointestinal tumor were randomly divided into control group and observation group.Efficacy was compared between two groups by detecting the changes of various nutritional and immune indexes before and after chemotherapy.Results There were no significant differences of the nutritional and immune func-tion indexes between two groups before chemotherapy and after the first-second cycle of chemothera-py.All nutritional and immune function indexes after the third cycle of chemotherapy in the obser-vation group were significantly better than those in the control group.The incidence rate of compli-cations such as leucopenia,thrombocytopenia,nausea,vomiting and diarrhea in the observation group was significantly lower than the control group.Conclusion PN supportive therapy can not only ameliorate the nutritional status and immune function of patients with advanced gastrointestinal tumor,but also alleviate the chemotherapy-induced adverse reactions,so it is very important for safety in peri-chemotherapy period.
Objective To explore the influence of parenteral nutrition (PN)supportive therapy on the nutritional status and immune function in patients with advanced gastrointestinal tu-mor in peri-chemotherapy period.Methods 90 patients with advanced gastrointestinal tumor were randomly divided into control group and observation group.Efficacy was compared between two groups by detecting the changes of various nutritional and immune indexes before and after chemotherapy.Results There were no significant differences of the nutritional and immune func-tion indexes between two groups before chemotherapy and after the first-second cycle of chemothera-py.All nutritional and immune function indexes after the third cycle of chemotherapy in the obser-vation group were significantly better than those in the control group.The incidence rate of compli-cations such as leucopenia,thrombocytopenia,nausea,vomiting and diarrhea in the observation group was significantly lower than the control group.Conclusion PN supportive therapy can not only ameliorate the nutritional status and immune function of patients with advanced gastrointestinal tumor,but also alleviate the chemotherapy-induced adverse reactions,so it is very important for safety in peri-chemotherapy period.
Abstract：
Objective To explore the effect of hemoperfusion(HP)combined with continu-ous veno-venous hemofiltration (CVVH)on treatment of patients with severe acute pancreatitis (SAP).Methods 16 patients with SAP were treated with combination therapy of conventional treatment plus HP and CVVH.Efficacy and dynamic changes of clinical indicators were observed af-ter treatment.Results After 24 hours,the temperature,heart rate,respiration,MAP,serum creatinine,blood urea nitrogen,AMS,CRP and APACHE Ⅱ score were significantly better than those before treatment(P <0.05).The PO2,WBC count improved significantly after 48 hours (P<0.05).In all of the 16 patients,12 patients discharged finally,4 patients died,and the mortality rate was 25.0%;Conclusion For patients with SAP,combination therapy of conventional treat-ment plus HP and CVVH can clear inflammatory mediators,improve clinical symptoms and hold back the damages on tissues and organs caused by inflammatory mediators,so it is an effective mea-sure for the treatment of SAP.
Objective To explore the effect of hemoperfusion(HP)combined with continu-ous veno-venous hemofiltration (CVVH)on treatment of patients with severe acute pancreatitis (SAP).Methods 16 patients with SAP were treated with combination therapy of conventional treatment plus HP and CVVH.Efficacy and dynamic changes of clinical indicators were observed af-ter treatment.Results After 24 hours,the temperature,heart rate,respiration,MAP,serum creatinine,blood urea nitrogen,AMS,CRP and APACHE Ⅱ score were significantly better than those before treatment(P <0.05).The PO2,WBC count improved significantly after 48 hours (P<0.05).In all of the 16 patients,12 patients discharged finally,4 patients died,and the mortality rate was 25.0%;Conclusion For patients with SAP,combination therapy of conventional treat-ment plus HP and CVVH can clear inflammatory mediators,improve clinical symptoms and hold back the damages on tissues and organs caused by inflammatory mediators,so it is an effective mea-sure for the treatment of SAP.
Abstract：
Objective To explore the influence of simvastatin combined with clopidogrel on prognosis and levels of IL-6 and hs-CRP CRP in patients with unstable angina pectoris (UAP). Methods 105 patients with UAP from January 2011 to January 2013 were randomly divided into observation group (n =53)and control group (n =52).On the basis of conventional treatment, control group was treated with clopidogrel,while observation group was treated with simvastatin plus clopidogrel.Clinical efficacy,levels of IL-6 and hs-CRP and cardiovascular events were com-pared between two groups.Results The total effective rate was 59.6% in the control group, which was significantly lower than 86.8% in the observation group (P <0.01).After treatment, levels of IL-6 and hs-CRP decreased significantly in both groups (P <0.05),and there were signifi-cant differences between two groups (P <0.05).All the patients were followed up for 30 days,and there were significant differences in aspect of incidence of postoperative angina and myocardial in-farction between two groups (P <0.05).Conclusion Calcium clopidogrel combined with simvas-tatin can effectively improve levels of IL-6 and hs-CRP in the treatment of patients with UAP.
Objective To explore the influence of simvastatin combined with clopidogrel on prognosis and levels of IL-6 and hs-CRP CRP in patients with unstable angina pectoris (UAP). Methods 105 patients with UAP from January 2011 to January 2013 were randomly divided into observation group (n =53)and control group (n =52).On the basis of conventional treatment, control group was treated with clopidogrel,while observation group was treated with simvastatin plus clopidogrel.Clinical efficacy,levels of IL-6 and hs-CRP and cardiovascular events were com-pared between two groups.Results The total effective rate was 59.6% in the control group, which was significantly lower than 86.8% in the observation group (P <0.01).After treatment, levels of IL-6 and hs-CRP decreased significantly in both groups (P <0.05),and there were signifi-cant differences between two groups (P <0.05).All the patients were followed up for 30 days,and there were significant differences in aspect of incidence of postoperative angina and myocardial in-farction between two groups (P <0.05).Conclusion Calcium clopidogrel combined with simvas-tatin can effectively improve levels of IL-6 and hs-CRP in the treatment of patients with UAP.
Abstract：
Objective To explore the relationship between the mutation of epidermal growth factor receptor (EGFR)and KRAS genes and clinical pathological features in Uyghur pa-tients with non-small cell lung cancer (NSCLC)in Xinjiang.Methods The mutations of EGFR gene exons 18,19,20 and 21 as well as 7 sorts of hot somatic cells in KRAS gene codons 12 and 13 in 50 NSCLC tissues were detected by probe amplification refractory mutation system,and the cor-relation between the mutation of EGFR and KRAS genes and clinical pathological features in Uyghur patients was analyzed.Results Among 50 specimens,the total detection rate of EGFR was 12.0%,in which 4 belonged to deletion mutantion of exon 19,and 2 to L858R point mutation of exon 21.The total detection rate of KRAS was 10%,all of which belonged to Gly12Ala mutation on codon 12.No one simultaneously occurred EGFR and KRAS mutations.The detection rates of EGFR and KRAS genes in adenocarcinoma ,squamous carcinoma and large cell carcinoma were 2 7 .8 % ,3 .5 % ,0 % and2 2 .2 % ,3 .5 % ,0 % respectively .Themutation rateofEGFR in patients with adenocarcinoma (27.8%)was significantly higher than those without adenocarcino-ma (3.1%).There was significant difference of the KRAS gene mutation between patients with /without adenocarcinoma.The mutations of EGFR and KRAS genes in Uyghur patients were not related to the age,gender,smoking,TNM staging and ECOG score.Conclusion Compared with Chinese population,the mutation rate of EGFR in Uyghur patients with NSCLC is lower, but that of KRAS is higher,similar to the mutation of European Caucasian population.
Objective To explore the relationship between the mutation of epidermal growth factor receptor (EGFR)and KRAS genes and clinical pathological features in Uyghur pa-tients with non-small cell lung cancer (NSCLC)in Xinjiang.Methods The mutations of EGFR gene exons 18,19,20 and 21 as well as 7 sorts of hot somatic cells in KRAS gene codons 12 and 13 in 50 NSCLC tissues were detected by probe amplification refractory mutation system,and the cor-relation between the mutation of EGFR and KRAS genes and clinical pathological features in Uyghur patients was analyzed.Results Among 50 specimens,the total detection rate of EGFR was 12.0%,in which 4 belonged to deletion mutantion of exon 19,and 2 to L858R point mutation of exon 21.The total detection rate of KRAS was 10%,all of which belonged to Gly12Ala mutation on codon 12.No one simultaneously occurred EGFR and KRAS mutations.The detection rates of EGFR and KRAS genes in adenocarcinoma ,squamous carcinoma and large cell carcinoma were 2 7 .8 % ,3 .5 % ,0 % and2 2 .2 % ,3 .5 % ,0 % respectively .Themutation rateofEGFR in patients with adenocarcinoma (27.8%)was significantly higher than those without adenocarcino-ma (3.1%).There was significant difference of the KRAS gene mutation between patients with /without adenocarcinoma.The mutations of EGFR and KRAS genes in Uyghur patients were not related to the age,gender,smoking,TNM staging and ECOG score.Conclusion Compared with Chinese population,the mutation rate of EGFR in Uyghur patients with NSCLC is lower, but that of KRAS is higher,similar to the mutation of European Caucasian population.
Abstract：
Objective:To explore the influence of lymph node factors on postoperative radia-tion efficacy in patients with esophageal cancer.Methods 156 patients with esophageal cancer opera-tion were treated with three dimensional conformal radiotherapy.95%PTV =DT:50 to 60 Gy/25 to 30 fx.If shortest diameter of the mediastinal lymph node was greater than 0.8 cm or the margin was posi-tive,then radiation dose increased to 60 Gy.Results The 1,3 and 5 years overall survival rates of 156 esophageal cancer patients with postoperative radiotherapy were 88.5%,57.1% and 46.0% re-spectively.The median survival time was 49.08 months.The 1,3 and 5 years survival rates of lymph node-positive group and lymph node negative group were 8 2 .3 % ,4 7 .8 % ,4 1 .1 % and 9 4 .8 % , 66.9%,50.8% respectively(P =0.049).The 1,3 and 5 years survival rates of one to two positive nodes group and three or more positive lymph nodes group were 88.3%,51.7%,42.7% and 63.2%, 35.5%,35.5% respectively(P =0.028).The 1,3,5 years survival rate of lymph node metastasis rate ≤ 0.15 group and >0.15 group were 93.0%,65.0%,50.3% and 75.6%,35.6%,32.4%respectively(P =0.036).Conclusion The numbers of lymph node metastasis and lymph node me-tastasis rate show a significant influencing on survival rate of esophageal cancer patient with prophylac-tic irradiation.The larger the number of lymph node metastasis is,the lower the survival rate is.Value of concurrent chemoradiotherapy in high-risk postoperative esophageal cancer patients should be ex-plored further.
Objective:To explore the influence of lymph node factors on postoperative radia-tion efficacy in patients with esophageal cancer.Methods 156 patients with esophageal cancer opera-tion were treated with three dimensional conformal radiotherapy.95%PTV =DT:50 to 60 Gy/25 to 30 fx.If shortest diameter of the mediastinal lymph node was greater than 0.8 cm or the margin was posi-tive,then radiation dose increased to 60 Gy.Results The 1,3 and 5 years overall survival rates of 156 esophageal cancer patients with postoperative radiotherapy were 88.5%,57.1% and 46.0% re-spectively.The median survival time was 49.08 months.The 1,3 and 5 years survival rates of lymph node-positive group and lymph node negative group were 8 2 .3 % ,4 7 .8 % ,4 1 .1 % and 9 4 .8 % , 66.9%,50.8% respectively(P =0.049).The 1,3 and 5 years survival rates of one to two positive nodes group and three or more positive lymph nodes group were 88.3%,51.7%,42.7% and 63.2%, 35.5%,35.5% respectively(P =0.028).The 1,3,5 years survival rate of lymph node metastasis rate ≤ 0.15 group and >0.15 group were 93.0%,65.0%,50.3% and 75.6%,35.6%,32.4%respectively(P =0.036).Conclusion The numbers of lymph node metastasis and lymph node me-tastasis rate show a significant influencing on survival rate of esophageal cancer patient with prophylac-tic irradiation.The larger the number of lymph node metastasis is,the lower the survival rate is.Value of concurrent chemoradiotherapy in high-risk postoperative esophageal cancer patients should be ex-plored further.
Abstract：
Objective To explore the influence of intensive glycemic control by insulin pump on prognosis of critically ill patients with lung infection and respiratory failure.Methods In the emergency intensive care unit (EICU),200 critically ill patients with hyperglycemia (A-PACHE II score >15 ,random blood glucose > 11.1 mmol /L)were collected and randomly di-vided into the intensive insulin therapy (IIT)group and the convention insulin therapy(CIT) group(use insulin pump to control blood glucose).IIT group and CIT group included 31 cases and 33 cases of pulmonary infection and respiratory failure.Ventilator and antibiotic use days,short-term mortality (within 28 days),rate of hypoglycemia,nosocomial infection,hospital stay and hospital costs were observed and compared between two groups.Results There was no significant differences between two groups in aspects of age,sex ratio,oxygen saturation,pressure of oxygen, pressure of Carbon dioxide,pH,blood pressure,respiratory failure type,blood glucose,elec-trolytes,inflammation,heart function,liver and kidney function,fasting C peptide,HbAlc and APACHE Ⅱ score(P >0.05).APACHE II score at the time of 3 days and 7 days after admission, nosocomial infection,short-term mortality hospital day and hospital costs (P <0.05)in the IIT group were significantly lower and shorter than the CIT group.The hypoglycemia incidence rate of the IIT group was significantly higher than that of the CIT group (P <0.01).Result of serious hypoglycemia showed no significant difference between the two groups .Conclusion Strict intensive glucose control on pulmonary infection and respiratory failure may bring more benefits for acute and critically ill patients,and it can reduce the short-term mortality rate.
Objective To explore the influence of intensive glycemic control by insulin pump on prognosis of critically ill patients with lung infection and respiratory failure.Methods In the emergency intensive care unit (EICU),200 critically ill patients with hyperglycemia (A-PACHE II score >15 ,random blood glucose > 11.1 mmol /L)were collected and randomly di-vided into the intensive insulin therapy (IIT)group and the convention insulin therapy(CIT) group(use insulin pump to control blood glucose).IIT group and CIT group included 31 cases and 33 cases of pulmonary infection and respiratory failure.Ventilator and antibiotic use days,short-term mortality (within 28 days),rate of hypoglycemia,nosocomial infection,hospital stay and hospital costs were observed and compared between two groups.Results There was no significant differences between two groups in aspects of age,sex ratio,oxygen saturation,pressure of oxygen, pressure of Carbon dioxide,pH,blood pressure,respiratory failure type,blood glucose,elec-trolytes,inflammation,heart function,liver and kidney function,fasting C peptide,HbAlc and APACHE Ⅱ score(P >0.05).APACHE II score at the time of 3 days and 7 days after admission, nosocomial infection,short-term mortality hospital day and hospital costs (P <0.05)in the IIT group were significantly lower and shorter than the CIT group.The hypoglycemia incidence rate of the IIT group was significantly higher than that of the CIT group (P <0.01).Result of serious hypoglycemia showed no significant difference between the two groups .Conclusion Strict intensive glucose control on pulmonary infection and respiratory failure may bring more benefits for acute and critically ill patients,and it can reduce the short-term mortality rate.
Abstract：
Objective To explore the feasibility,safety and efficacy of laparoscopy-assisted radical total gastrectomy(LATG).Methods Clinical materials of LATG patients and open total gas-trectomy (OTG)patients were analyzed retrospectively.Feasibility,safety and short-term outcomes were compared between two groups.Results 274 patients were collected,and there were 109 cases in the LATG group and 165 cases in the OTG group.Operation time in the TLTG group [(187.9 ± 37.6)minutes]was significantly longer than that in the OTG group (P <0.001 ),while the intra-operative blood losswassignificantlylowerthan the LATGgroup [(1 66 .5 ±5 9 .3 )mL:(3 09 .4 ± 93.1)mL](P <0.001).First flatus time (P <0.001),first diet time (P <0.001),post operative hospital stay (P <0.001),white blood cells counting (P <0.05),and drainage (P <0.05)in the LATG group were significantly lower than those in the OTG group.Conclusion LATG is a safe and feasible procedure for the treatment of gastric cancer,and it has advantages such as high security, small trauma and quick post-operative recovery.
Objective To explore the feasibility,safety and efficacy of laparoscopy-assisted radical total gastrectomy(LATG).Methods Clinical materials of LATG patients and open total gas-trectomy (OTG)patients were analyzed retrospectively.Feasibility,safety and short-term outcomes were compared between two groups.Results 274 patients were collected,and there were 109 cases in the LATG group and 165 cases in the OTG group.Operation time in the TLTG group [(187.9 ± 37.6)minutes]was significantly longer than that in the OTG group (P <0.001 ),while the intra-operative blood losswassignificantlylowerthan the LATGgroup [(1 66 .5 ±5 9 .3 )mL:(3 09 .4 ± 93.1)mL](P <0.001).First flatus time (P <0.001),first diet time (P <0.001),post operative hospital stay (P <0.001),white blood cells counting (P <0.05),and drainage (P <0.05)in the LATG group were significantly lower than those in the OTG group.Conclusion LATG is a safe and feasible procedure for the treatment of gastric cancer,and it has advantages such as high security, small trauma and quick post-operative recovery.
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Objective To explore role of damage control surgery in the treatment of patients with abdominal trauma and severe multiple injuries.Methods 60 elderly patients with abdominal trauma were collected and divided into death group (n =10)and survival group (n =50)according to the prognosis.According to the ISS score,patients were divided into group A (n =25,16 to 24 points),group B (n =23,25 to 34 points)and group C (n =12,>35 points).Death and survival cases in patients with craniocerebral injury,mean ISS value and complications,ISS score and the number of injury,surgical site number,deterministic operation time,blood transfusion amount, length of hospital stay,the relationship between complications and mortality were observed in both groups.Results There were significant differences of craniocerebral injury and complications in death and survival group (P <0.05).There were significant differences of ISS score in group A, group B and group C (P <0.01).Operation time,blood transfusion amount,length of hospital stay increased with the increasing of ISS score (P <0.01).There were significant differences of complications and death cases in group A,group B and group C (P <0.05).Conclusion ISS score can guide therapy and evaluate prognosis,and damage control surgery can significantly reduce the postoperative incidence rate of complications and mortality in elderly patients with trauma.
Objective To explore role of damage control surgery in the treatment of patients with abdominal trauma and severe multiple injuries.Methods 60 elderly patients with abdominal trauma were collected and divided into death group (n =10)and survival group (n =50)according to the prognosis.According to the ISS score,patients were divided into group A (n =25,16 to 24 points),group B (n =23,25 to 34 points)and group C (n =12,>35 points).Death and survival cases in patients with craniocerebral injury,mean ISS value and complications,ISS score and the number of injury,surgical site number,deterministic operation time,blood transfusion amount, length of hospital stay,the relationship between complications and mortality were observed in both groups.Results There were significant differences of craniocerebral injury and complications in death and survival group (P <0.05).There were significant differences of ISS score in group A, group B and group C (P <0.01).Operation time,blood transfusion amount,length of hospital stay increased with the increasing of ISS score (P <0.01).There were significant differences of complications and death cases in group A,group B and group C (P <0.05).Conclusion ISS score can guide therapy and evaluate prognosis,and damage control surgery can significantly reduce the postoperative incidence rate of complications and mortality in elderly patients with trauma.
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Objective To explore the influence of target controlled infusion (TCI)on physi-cal sign and immunologic function of the patients with radical resection of rectal carcinoma.Methods Post-anesthetic physical sign,levels of IL-6 and TNF-αand change of Tregs in 26 patients with radical resection of rectal carcinoma were analyzed.Results There were significant differences of every index of physical sign and levels of IL-6 and TNF-αin patients between intraoperative period and preoperative and one hour after operation (P <0.05).There was significant difference of level of Tregs between intraoperative period and preoperative period(P <0.05).Conclusion TCI shows a certain influence on physical sign of patients,and each index of physical sign should be monitored carefully in order to avoid the incidence of complications.Meanwhile,it shows a short-term influ-ence on the immune function as well,but depending on rapid recovery,this influence won′t cause a long-term decline of immune function.
Objective To explore the influence of target controlled infusion (TCI)on physi-cal sign and immunologic function of the patients with radical resection of rectal carcinoma.Methods Post-anesthetic physical sign,levels of IL-6 and TNF-αand change of Tregs in 26 patients with radical resection of rectal carcinoma were analyzed.Results There were significant differences of every index of physical sign and levels of IL-6 and TNF-αin patients between intraoperative period and preoperative and one hour after operation (P <0.05).There was significant difference of level of Tregs between intraoperative period and preoperative period(P <0.05).Conclusion TCI shows a certain influence on physical sign of patients,and each index of physical sign should be monitored carefully in order to avoid the incidence of complications.Meanwhile,it shows a short-term influ-ence on the immune function as well,but depending on rapid recovery,this influence won′t cause a long-term decline of immune function.
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Objective To explore the influence of intravenous inhalation anesthesia and to-tal intravenous anesthesia on inflammatory cytokines of patients with breast cancer.Methods 132 breast cancer patients treated with operation were randomly divided into group A(intravenous in-halation anesthesia,n =66)and group B(total intravenous anesthesia,n =66).Levels of IL-6 and TNF-αwere detected and compared in both groups.Results After the operation,the levels of IL-6 and TNF-αwere significantly higher than those before the operation in both groups(P <0.05). IL-6 level in the group A was significantly higher than group B at the time of 6 hours after the op-eration(P <0.01),and TNF-αwere significantly higher than group B at the time points of 4 and 6 hours after the operation (P <0.01).Conclusion Total intravenous anesthesia can suppress the postoperative increasing of serum IL-6,TNF-αand other inflammatory cytokines in patients with breast cancer in order to avoid excessive stress,so it is worthy of popularization.
Objective To explore the influence of intravenous inhalation anesthesia and to-tal intravenous anesthesia on inflammatory cytokines of patients with breast cancer.Methods 132 breast cancer patients treated with operation were randomly divided into group A(intravenous in-halation anesthesia,n =66)and group B(total intravenous anesthesia,n =66).Levels of IL-6 and TNF-αwere detected and compared in both groups.Results After the operation,the levels of IL-6 and TNF-αwere significantly higher than those before the operation in both groups(P <0.05). IL-6 level in the group A was significantly higher than group B at the time of 6 hours after the op-eration(P <0.01),and TNF-αwere significantly higher than group B at the time points of 4 and 6 hours after the operation (P <0.01).Conclusion Total intravenous anesthesia can suppress the postoperative increasing of serum IL-6,TNF-αand other inflammatory cytokines in patients with breast cancer in order to avoid excessive stress,so it is worthy of popularization.
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Objectives To observe and analyze the efficacy and safety of the different opera-tion methods in the treatment of hard nucleus cataract after glaucoma surgery.Methods 100 pa-tients with hard nucleus cataract after glaucoma operation were selected.According to the different treatment methods,the patients were divided into the observation group (n =54,75 eyes)and the control group (n =46,61 eyes).The observation group was treated with manual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision,while the control group was treated with the phacoemulsification through clarity corneal incision.All the patients were followed up for 3 to 6 months.Changes of visual acuity,the depth of anterior chamber,intraocular pressure and corneal endothelial cell counting before and after operation as well as the adverse reactions were observed and compared.Results Compared with visual acuity before treatment,the visual acuity of the patients in both groups improved significantly after treatment(P <0.05).The anterior chamber depth grades of patients in both groups were significantly higher than those before treat-ment (P <0.05),and after treatment,the anterior chamber depth grade of the patients in the observation group was significantly better than that in the control group (P <0.05).There was no significant difference of intraocular pressure before and after the treatment in both groups (P>0.05).The corneal endothelial cell density of the patients in the observation group decreased (P >0.05),while that in the control group decreased significantly (P <0.05).The corneal en-dothelial cell density of the patients in the observation group after the corneal endothelium was significantly higher than that in the control group (P <0.05).The incidence rates of adverse re-action in the two groups were 21.33%(16 /75)and 21.31%(13 /61)respectively,and the symp-tom were controlled and cured after the symptomatic treatment.Conclusion Application of man-ual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision for the patients with hard nucleus cataract after glaucoma surgery can effectively improve the visual acuity and anterior chamber depth of the patients.It is safe and better than ultrasonic emulsification nu-cleus surgery in the aspects of improving anterior chamber depth and reducing the injury to corneal cells.It is worthy of clinical application.
Objectives To observe and analyze the efficacy and safety of the different opera-tion methods in the treatment of hard nucleus cataract after glaucoma surgery.Methods 100 pa-tients with hard nucleus cataract after glaucoma operation were selected.According to the different treatment methods,the patients were divided into the observation group (n =54,75 eyes)and the control group (n =46,61 eyes).The observation group was treated with manual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision,while the control group was treated with the phacoemulsification through clarity corneal incision.All the patients were followed up for 3 to 6 months.Changes of visual acuity,the depth of anterior chamber,intraocular pressure and corneal endothelial cell counting before and after operation as well as the adverse reactions were observed and compared.Results Compared with visual acuity before treatment,the visual acuity of the patients in both groups improved significantly after treatment(P <0.05).The anterior chamber depth grades of patients in both groups were significantly higher than those before treat-ment (P <0.05),and after treatment,the anterior chamber depth grade of the patients in the observation group was significantly better than that in the control group (P <0.05).There was no significant difference of intraocular pressure before and after the treatment in both groups (P>0.05).The corneal endothelial cell density of the patients in the observation group decreased (P >0.05),while that in the control group decreased significantly (P <0.05).The corneal en-dothelial cell density of the patients in the observation group after the corneal endothelium was significantly higher than that in the control group (P <0.05).The incidence rates of adverse re-action in the two groups were 21.33%(16 /75)and 21.31%(13 /61)respectively,and the symp-tom were controlled and cured after the symptomatic treatment.Conclusion Application of man-ual nuclear delivery after ultrasonic chopping nucleus through small scleral tunnel incision for the patients with hard nucleus cataract after glaucoma surgery can effectively improve the visual acuity and anterior chamber depth of the patients.It is safe and better than ultrasonic emulsification nu-cleus surgery in the aspects of improving anterior chamber depth and reducing the injury to corneal cells.It is worthy of clinical application.
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Objective To compare the efficacy and safety of intravenous chemotherapy plus operation and interventional arterial chemotherapy plus operation in treatment of patients with local-ly advanced cervical carcinoma (phases Ib2~IIb).Methods 140 patients with locally advanced cervical carcinoma (phases Ib2~IIb)were divided into experimental group (uterine artery interven-tional chemotherapy plus surgery)and control group (venous chemotherapy plus surgery)according to different initial therapeutic methods,70 cases in each group.Short-term efficacy,tumor diameter changes before and after treatment,rate of radical operation,3 and 5 years overall survival (OS), progression-free survival (PFS),complications as well as pathological risk factors (rates of para-u-terine invasion and lymph node metastasis)were observed.Results Short-term efficacy improved in both groups.The decreased tumor diameter in experimental group was significantly greater than control group,and the probability rate of patients with radical operation was significantly larger than the control group.Corresponding rates of para-uterine invasion and lymph node metastasis in the ex-perimental group were significantly lower than the control group.There were no significant differ-ences of 3 years OS and PFS between two groups,and the 5 years OS and PFS in the experimental group were higher than the control group.Conclusion For patients with locally advanced cervical carcinoma,neo-adjuvant chemotherapy with artery interventional therapy is better than intravenous chemotherapy in aspects of surgical resection rate and 5 years OS,so it is a safe and effective thera-peutic method.
Objective To compare the efficacy and safety of intravenous chemotherapy plus operation and interventional arterial chemotherapy plus operation in treatment of patients with local-ly advanced cervical carcinoma (phases Ib2~IIb).Methods 140 patients with locally advanced cervical carcinoma (phases Ib2~IIb)were divided into experimental group (uterine artery interven-tional chemotherapy plus surgery)and control group (venous chemotherapy plus surgery)according to different initial therapeutic methods,70 cases in each group.Short-term efficacy,tumor diameter changes before and after treatment,rate of radical operation,3 and 5 years overall survival (OS), progression-free survival (PFS),complications as well as pathological risk factors (rates of para-u-terine invasion and lymph node metastasis)were observed.Results Short-term efficacy improved in both groups.The decreased tumor diameter in experimental group was significantly greater than control group,and the probability rate of patients with radical operation was significantly larger than the control group.Corresponding rates of para-uterine invasion and lymph node metastasis in the ex-perimental group were significantly lower than the control group.There were no significant differ-ences of 3 years OS and PFS between two groups,and the 5 years OS and PFS in the experimental group were higher than the control group.Conclusion For patients with locally advanced cervical carcinoma,neo-adjuvant chemotherapy with artery interventional therapy is better than intravenous chemotherapy in aspects of surgical resection rate and 5 years OS,so it is a safe and effective thera-peutic method.
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Objective To explore the efficacy and safety of nasal polypectomy combined with intranasal ethmoidectomy in treating nasal polyp.Methods 80 patients with nasal polyps (ob-servation group)were treated with nasal polypectomy combined with intranasal ethmoidectomy. Therapeutic effect,the postoperative complications and 1 year relapse were observed and compared with the results reported by HUANG Yuanhong,LI Feng,LI Weiping.Results Cure rate (75%)in the observation group was significantly higher than HUANG Yuanhong group,LI Weip-ing group and LI Feng group (χ2=4.365,4.342,4.365,P =0.034,0.033,0.028,P <0.05), while total effective rate (97.5%)was significantly higher than LI Feng group (χ2=3.846,P =0.038 <0.05.Incidence rate of complications (2.5%)in the observation group was significantly lower than HUANG Yuanhong group,LI Weiping group and LI Feng group (χ2=5.365,9.126, 5.365,P =0.034,0.012,0.006,<0.05),and the recurrence rate (1.25%)was significantly lower than HUANG Yuanhong group and LI Weiping group (χ2=18.365,24.321,P <0.01). Conclusion Nasal polypectomy combined with intranasal ethmoidectomy can reduce the complica-tions,alleviate postoperative pain,prevent postoperative recurrence,and its clinical efficacy is bet-ter.
Objective To explore the efficacy and safety of nasal polypectomy combined with intranasal ethmoidectomy in treating nasal polyp.Methods 80 patients with nasal polyps (ob-servation group)were treated with nasal polypectomy combined with intranasal ethmoidectomy. Therapeutic effect,the postoperative complications and 1 year relapse were observed and compared with the results reported by HUANG Yuanhong,LI Feng,LI Weiping.Results Cure rate (75%)in the observation group was significantly higher than HUANG Yuanhong group,LI Weip-ing group and LI Feng group (χ2=4.365,4.342,4.365,P =0.034,0.033,0.028,P <0.05), while total effective rate (97.5%)was significantly higher than LI Feng group (χ2=3.846,P =0.038 <0.05.Incidence rate of complications (2.5%)in the observation group was significantly lower than HUANG Yuanhong group,LI Weiping group and LI Feng group (χ2=5.365,9.126, 5.365,P =0.034,0.012,0.006,<0.05),and the recurrence rate (1.25%)was significantly lower than HUANG Yuanhong group and LI Weiping group (χ2=18.365,24.321,P <0.01). Conclusion Nasal polypectomy combined with intranasal ethmoidectomy can reduce the complica-tions,alleviate postoperative pain,prevent postoperative recurrence,and its clinical efficacy is bet-ter.
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Objective To explore effect of simvastatin combined with clopidogrel on treat-ment of patients with unstable angina and its influence on serum hs-CRP and IL-6.Methods 80 patients with unstable angina were randomly divided into two groups.Simvastatin group was treat-ed with simvastatin and other conventional treatment,while the combined group was treated with clopidogrel on the basis of simvastatin group.Efficacy and changes of serum hs-CRP and IL-6 were observed before and after treatment.Results After treatment,the total effective rate in combined group was 9 0 .0 % ,which was significantly higher than 7 5 .0 % in the simvastatin group (P <0.05).The levels of TC and TG decreased significantly in both groups (P <0.05),and there were no significant differences between two groups (P >0.05).After treatment,the levels of serum hs-CRP and IL-6 decreased significantly in both groups(P <0.05),and levels of serum hs-CRP and IL-6 in the combined group was significantly lower than those in the simvastatin group (P <0.05).Conclusion Application of simvastatin combined with clopidogrel in treatment of pa-tients with unstable angina can improve clinical symptoms.
Objective To explore effect of simvastatin combined with clopidogrel on treat-ment of patients with unstable angina and its influence on serum hs-CRP and IL-6.Methods 80 patients with unstable angina were randomly divided into two groups.Simvastatin group was treat-ed with simvastatin and other conventional treatment,while the combined group was treated with clopidogrel on the basis of simvastatin group.Efficacy and changes of serum hs-CRP and IL-6 were observed before and after treatment.Results After treatment,the total effective rate in combined group was 9 0 .0 % ,which was significantly higher than 7 5 .0 % in the simvastatin group (P <0.05).The levels of TC and TG decreased significantly in both groups (P <0.05),and there were no significant differences between two groups (P >0.05).After treatment,the levels of serum hs-CRP and IL-6 decreased significantly in both groups(P <0.05),and levels of serum hs-CRP and IL-6 in the combined group was significantly lower than those in the simvastatin group (P <0.05).Conclusion Application of simvastatin combined with clopidogrel in treatment of pa-tients with unstable angina can improve clinical symptoms.
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Objective To explore the influence of irbesartan and metoprolol on the ambula-tory blood pressure of patients with hypertension.Methods 80 patients with primary hypertension were selected and randomly divided into irbesartan group and metoprolol group,40 cases in each group.24 hours ambulatory blood pressure monitoring (ABPM)before treatment and 3 months af-ter treatment was conducted,and pressure control was observed in both groups.Results Before treatment,there was no significant difference of blood pressure between two groups,and blood pressure decreased significantly after treatment,and mean 24 hours diastolic blood pressure (DBP) at night after treatment did not change greatly.There were significant differences of 24 hours sys-tolic blood pressure (SBP),24 hours DBP,SBP and DBP at daytime and night,which decreased much more significantly in irbesartan group than in metoprolol group.Conclusion Irbesartan and metoprolol both have a favorable anti-hypertensive effect on primary hypertension,but irbesartan is more effective.
Objective To explore the influence of irbesartan and metoprolol on the ambula-tory blood pressure of patients with hypertension.Methods 80 patients with primary hypertension were selected and randomly divided into irbesartan group and metoprolol group,40 cases in each group.24 hours ambulatory blood pressure monitoring (ABPM)before treatment and 3 months af-ter treatment was conducted,and pressure control was observed in both groups.Results Before treatment,there was no significant difference of blood pressure between two groups,and blood pressure decreased significantly after treatment,and mean 24 hours diastolic blood pressure (DBP) at night after treatment did not change greatly.There were significant differences of 24 hours sys-tolic blood pressure (SBP),24 hours DBP,SBP and DBP at daytime and night,which decreased much more significantly in irbesartan group than in metoprolol group.Conclusion Irbesartan and metoprolol both have a favorable anti-hypertensive effect on primary hypertension,but irbesartan is more effective.
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Objective To explore the clinical effect of Jinshuibao capsule combined with losartan potassium on treatment of patients with early type 2 diabetic nephropathy (DN).Methods 82 patients with early type 2 DN were randomly divided into control group and treatment group, 41 cases in each group.Based on conventional comprehensive treatment,the control group was treated with losartan potassium,while the treatment group was treated with Jinshuibao capsule and losartan potassium.Levels of serum creatinine (Scr),cystatin C (Cys C),urine microalbumin (MAU)and urinary albumin excretion rate (UAER)were compared between two groups before and after treatment.Results After treatment,the levels of Scr,Cys-C,MAU and UAER in both groups decreased,and the levels of Scr,Cys C,MAU and UAER in treatment group were signifi-cantly lower than those in control group.Conclusion Jinshuibao capsule combined with losartan potassium can significantly improve the renal function in patients with early type 2 DN,alleviate urine protein and delay DN progression.
Objective To explore the clinical effect of Jinshuibao capsule combined with losartan potassium on treatment of patients with early type 2 diabetic nephropathy (DN).Methods 82 patients with early type 2 DN were randomly divided into control group and treatment group, 41 cases in each group.Based on conventional comprehensive treatment,the control group was treated with losartan potassium,while the treatment group was treated with Jinshuibao capsule and losartan potassium.Levels of serum creatinine (Scr),cystatin C (Cys C),urine microalbumin (MAU)and urinary albumin excretion rate (UAER)were compared between two groups before and after treatment.Results After treatment,the levels of Scr,Cys-C,MAU and UAER in both groups decreased,and the levels of Scr,Cys C,MAU and UAER in treatment group were signifi-cantly lower than those in control group.Conclusion Jinshuibao capsule combined with losartan potassium can significantly improve the renal function in patients with early type 2 DN,alleviate urine protein and delay DN progression.
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Objective To explore the clinical effect of metadoxine combined with polyene phosphatidyl choline on the treatment of patients with alcoholic liver disease (ALD).Methods 70 patients with ALD were randomly divided into treatment group and control group,35 cases in each group.On the basis of conventional therapy in both groups,the control group was treated with polyene phosphatidyl choline and treatment group was treated with metadoxine tablet combined with polyene phosphatidyl choline.Serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil),glutamyltranspeptidase (GGT),alkaline phosphatase (ALP)and conjugative bilirubin (DBil)before and after treatment were observed in both groups,and changes of clinical symptoms and physical signs were recorded,color ultrasound of liver was conducted and clinical efficacy was evaluated.Results 4 weeks after treatment,clinical efficacy in treatment group was significantly higher than control group.Every index of liver function in both groups decreased significantly,and the indexes in the treatment group were significantly lower than the control group.Improvements of mild,moderate and severe fatty liver in the treatment group were signifi-cantly better than those in the control group.Conclusion Metadoxine combined with polyene phosphatidyl choline is more effective than single polyene phosphatidyl choline in treating ALD.
Objective To explore the clinical effect of metadoxine combined with polyene phosphatidyl choline on the treatment of patients with alcoholic liver disease (ALD).Methods 70 patients with ALD were randomly divided into treatment group and control group,35 cases in each group.On the basis of conventional therapy in both groups,the control group was treated with polyene phosphatidyl choline and treatment group was treated with metadoxine tablet combined with polyene phosphatidyl choline.Serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil),glutamyltranspeptidase (GGT),alkaline phosphatase (ALP)and conjugative bilirubin (DBil)before and after treatment were observed in both groups,and changes of clinical symptoms and physical signs were recorded,color ultrasound of liver was conducted and clinical efficacy was evaluated.Results 4 weeks after treatment,clinical efficacy in treatment group was significantly higher than control group.Every index of liver function in both groups decreased significantly,and the indexes in the treatment group were significantly lower than the control group.Improvements of mild,moderate and severe fatty liver in the treatment group were signifi-cantly better than those in the control group.Conclusion Metadoxine combined with polyene phosphatidyl choline is more effective than single polyene phosphatidyl choline in treating ALD.
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Objective To investigate the efficacy and safety of tacrolimus in treatment of id-iopathic membranous nephropathy.Methods 41 patients with idiopathic membranous nephropathy (IMN)were randomly divided intotacrolimus group and CTX group .The tacrolimus group was treated with tacrolimus combined with glucocorticoid therapy while CTX group was given CTX combined with glucocorticoid therapy.The clinical indicators and efficiency,adverse reactions were observed before and after treatment.Results After 6 months,the levels of the 24 hour urinary protein,triglycerides,cholesterol in both groups decreased significantly (P <0.05),the serum al-bumin level was significantly higher (P < 0.05),but the improvement of these indicators in tacrolimus group were significantly better than that in the CTX group (P <0.05).The overall re-sponse rate in the tacrolimus group was significantly higher than that in the CTX group (90.48% vs 65.00%)(P <0.05).Conclusion Therapy of tacrolimus combined with glucocorticoids is an ef-fective and safe program in the treatment of IMN.
Objective To investigate the efficacy and safety of tacrolimus in treatment of id-iopathic membranous nephropathy.Methods 41 patients with idiopathic membranous nephropathy (IMN)were randomly divided intotacrolimus group and CTX group .The tacrolimus group was treated with tacrolimus combined with glucocorticoid therapy while CTX group was given CTX combined with glucocorticoid therapy.The clinical indicators and efficiency,adverse reactions were observed before and after treatment.Results After 6 months,the levels of the 24 hour urinary protein,triglycerides,cholesterol in both groups decreased significantly (P <0.05),the serum al-bumin level was significantly higher (P < 0.05),but the improvement of these indicators in tacrolimus group were significantly better than that in the CTX group (P <0.05).The overall re-sponse rate in the tacrolimus group was significantly higher than that in the CTX group (90.48% vs 65.00%)(P <0.05).Conclusion Therapy of tacrolimus combined with glucocorticoids is an ef-fective and safe program in the treatment of IMN.
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Objective To explore the effect of fludarabine on treatment of patients with chronic lymphocytic leukemia (CLL)and its influence on survival rate.Methods 32 elderly pa-tients with CLL were treated with fludarabine,and they were also divided into stage 0~Ⅱ (n =17)group and stage Ⅲ~Ⅳ (n =15)group according to clinical stage of disease.30 elderly pa-tients with medical examination were designed as control group.Number of peripheral blood lym-phocyte were compared between 3 groups,and the relationship between complete remission rate and the clinical related factors as well as survival rate within post-treatment 3 years in CLL pa-tients were observed.Results The number of CD4+ T cells in the control group was significantly higher than that in the stage Ⅲ~Ⅳ group (P <0.01).The number of CD4+ /CD8+ in the control group was significantly higher than that in the treatment group(P <0.05).There was a close rela-tionship between the complete remission rate of fludarabine treatment and the patient’s age,stag-ing and course of treatment.The survival rate within post-treatment 3 years was 65.6%.Con-clusion Fludarabine can significantly improve the patients′immune status and increase the com-plete remission rate and survival rate.
Objective To explore the effect of fludarabine on treatment of patients with chronic lymphocytic leukemia (CLL)and its influence on survival rate.Methods 32 elderly pa-tients with CLL were treated with fludarabine,and they were also divided into stage 0~Ⅱ (n =17)group and stage Ⅲ~Ⅳ (n =15)group according to clinical stage of disease.30 elderly pa-tients with medical examination were designed as control group.Number of peripheral blood lym-phocyte were compared between 3 groups,and the relationship between complete remission rate and the clinical related factors as well as survival rate within post-treatment 3 years in CLL pa-tients were observed.Results The number of CD4+ T cells in the control group was significantly higher than that in the stage Ⅲ~Ⅳ group (P <0.01).The number of CD4+ /CD8+ in the control group was significantly higher than that in the treatment group(P <0.05).There was a close rela-tionship between the complete remission rate of fludarabine treatment and the patient’s age,stag-ing and course of treatment.The survival rate within post-treatment 3 years was 65.6%.Con-clusion Fludarabine can significantly improve the patients′immune status and increase the com-plete remission rate and survival rate.
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Objective To observe the influence of citalopram on anxiety and depression of patient with functional dyspepsia (FD).Methods One hundred and thirty-two FD patients were randomly divided into treatment group (n =68)and control group (n =64).The patients in con-trol group were given omeprazole and mosapride,while the patients in the treatment group were added citalopram based on the treatment in the control group,and meanwhile given corresponding psychology guidance.The anxiety and depression disorders were evaluated respectively by Self-rat-ing Depression Scale (SDS)and Self-rating Anxiety Scale (SAS).The symptomatic scores before treatment and on the second,fourth and eighth week of treatment,clinical efficiency and adverse reactions were observed in the two groups.Results Among 132 patients,there were 60 with de-pression and 53 patients suffering from anxiety.SDS and SAS scores on on the second,fourth and eighth week of treatment and FD symptomatic scores on the fourth and eighth weeks of treatment were obviously lower,while the overall response rate was significantly higher in treatment group than that in the control group.So the difference was statistical significant.Before and after treat-ment,there were no abnormal patients in two groups.Conclusion FD patients are usually accom-panied by anxiety and depression.The application of citalopram on the basis of routine treatment could significantly ameliorate the patients′anxiety and depression,alleviate symptoms,improve the efficiency and reduce adverse reactions.
Objective To observe the influence of citalopram on anxiety and depression of patient with functional dyspepsia (FD).Methods One hundred and thirty-two FD patients were randomly divided into treatment group (n =68)and control group (n =64).The patients in con-trol group were given omeprazole and mosapride,while the patients in the treatment group were added citalopram based on the treatment in the control group,and meanwhile given corresponding psychology guidance.The anxiety and depression disorders were evaluated respectively by Self-rat-ing Depression Scale (SDS)and Self-rating Anxiety Scale (SAS).The symptomatic scores before treatment and on the second,fourth and eighth week of treatment,clinical efficiency and adverse reactions were observed in the two groups.Results Among 132 patients,there were 60 with de-pression and 53 patients suffering from anxiety.SDS and SAS scores on on the second,fourth and eighth week of treatment and FD symptomatic scores on the fourth and eighth weeks of treatment were obviously lower,while the overall response rate was significantly higher in treatment group than that in the control group.So the difference was statistical significant.Before and after treat-ment,there were no abnormal patients in two groups.Conclusion FD patients are usually accom-panied by anxiety and depression.The application of citalopram on the basis of routine treatment could significantly ameliorate the patients′anxiety and depression,alleviate symptoms,improve the efficiency and reduce adverse reactions.
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Objective To study the clinical significance of ST-T changes in electrocardio-gram to diagnose coronary heart disease in hypertensive patients.Methods One hundred and twelve patients with hypertension accompanied by chest pain in our hospital were divided into ST-T group with dynamic changes with 46 patients and ST-T group without dynamic changes with 66 patients according to ST-T changes.All patients were given electrocardiogram monitoring and coronary an-giography,and the relationship between the results of coronary angiography and ST-T dynamic changes was analyzed in both groups.Results There were 36 patients (32.1%)of positive coro-nary artery and 10 patients (8.9%)of negative coronary artery in ST-T group with dynamic changes,whereas there were 18 patients (16.1%)of positive coronary artery and 48 patients (42. 9%)of negative coronary artery in ST-T group without dynamic changes.The positive rate of coro-nary artery was evidently higher in ST-T group with dynamic changes than that in ST-T group without dynamic changes,and the difference was statistical significant.Conclusion ST-T dynamic changes in electrocardiogram of hypertensive patients has a certain correlation with the diagnosis of coronary heart disease,which can be considered as one of the references to diagnose the coronary heart disease.
Objective To study the clinical significance of ST-T changes in electrocardio-gram to diagnose coronary heart disease in hypertensive patients.Methods One hundred and twelve patients with hypertension accompanied by chest pain in our hospital were divided into ST-T group with dynamic changes with 46 patients and ST-T group without dynamic changes with 66 patients according to ST-T changes.All patients were given electrocardiogram monitoring and coronary an-giography,and the relationship between the results of coronary angiography and ST-T dynamic changes was analyzed in both groups.Results There were 36 patients (32.1%)of positive coro-nary artery and 10 patients (8.9%)of negative coronary artery in ST-T group with dynamic changes,whereas there were 18 patients (16.1%)of positive coronary artery and 48 patients (42. 9%)of negative coronary artery in ST-T group without dynamic changes.The positive rate of coro-nary artery was evidently higher in ST-T group with dynamic changes than that in ST-T group without dynamic changes,and the difference was statistical significant.Conclusion ST-T dynamic changes in electrocardiogram of hypertensive patients has a certain correlation with the diagnosis of coronary heart disease,which can be considered as one of the references to diagnose the coronary heart disease.
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Objective To observe the changes of thyroid function in elderly diabetic patients with hyperglycemic hyperosmolar status (HHS).Methods Clinical material of diabetic elderly pa-tients with hyperosmolar hyperglycemic state from 2009 to 2013 was retrospectively analyzed.Patients were divided into observation group and control group according to the occurrence of hyperosmolar hy-perglycemic state.There were 65 elderly diabetics patients with HHS in observation group and 45 dia-betic elderly patients without HHS in the control group.Results Patients in the observation group had higher levels of blood glucose,serum potassium,blood sodium,blood osmotic and base excess than that in the control group and the difference was statistically significant(P <0.05).The levels of T3 ,T4 and FT4 were lower in the observation group than that in the control group,the difference was statistically significant(P <0.05).After 4 days of treatment,patients in the observation group had higher levels of T3 ,T4 and FT4 than that of prior treatment,so the difference was statistically signifi-cant(P <0.05).Conclusion HHS of elderly diabetic patients could lead to the secondary hypo-function of thyroid and a series of acid base disturbance.With the treatment,the function of thyroid could be recovered.
Objective To observe the changes of thyroid function in elderly diabetic patients with hyperglycemic hyperosmolar status (HHS).Methods Clinical material of diabetic elderly pa-tients with hyperosmolar hyperglycemic state from 2009 to 2013 was retrospectively analyzed.Patients were divided into observation group and control group according to the occurrence of hyperosmolar hy-perglycemic state.There were 65 elderly diabetics patients with HHS in observation group and 45 dia-betic elderly patients without HHS in the control group.Results Patients in the observation group had higher levels of blood glucose,serum potassium,blood sodium,blood osmotic and base excess than that in the control group and the difference was statistically significant(P <0.05).The levels of T3 ,T4 and FT4 were lower in the observation group than that in the control group,the difference was statistically significant(P <0.05).After 4 days of treatment,patients in the observation group had higher levels of T3 ,T4 and FT4 than that of prior treatment,so the difference was statistically signifi-cant(P <0.05).Conclusion HHS of elderly diabetic patients could lead to the secondary hypo-function of thyroid and a series of acid base disturbance.With the treatment,the function of thyroid could be recovered.
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Objective To observe and analyze the effects of rehabilitation training com-bined with drugs in prevention from secondary osteoporosis patients with hemiplegia caused by stroke.Methods 120 patients with hemiplegia caused by stroke were randomly divided into obser-vation group and control group with 60 patients in each group.The patients in the control group were treated with rehabilitation training on the basis of the conventional therapy,while the pa-tients in the observation group were treated with the combined anti-osteoporosis drugs including salmon calcitonin and calcium carbonate vitamin D3 tablets based on the therapy of the control group.The bone density of femur proximal Ward River,distal radius,first lumbar spine at hemi-plegia side of research time,the first month and the third month after the treatment in the two groups were detected and compared.Results There were no significant differences in bone density of the three tested sites of patients at the research time between the two groups (P >0.05),while at the first month and the third month after the treatment,the bone density of the patients in the observation group at the three sites were significantly higher than those in the control group (P <0.05).Conclusions The combined application of drugs and rehabilitation training to the patients with post-stroke hemiplegia can gain significant effect in prevention from the osteoporosis.
Objective To observe and analyze the effects of rehabilitation training com-bined with drugs in prevention from secondary osteoporosis patients with hemiplegia caused by stroke.Methods 120 patients with hemiplegia caused by stroke were randomly divided into obser-vation group and control group with 60 patients in each group.The patients in the control group were treated with rehabilitation training on the basis of the conventional therapy,while the pa-tients in the observation group were treated with the combined anti-osteoporosis drugs including salmon calcitonin and calcium carbonate vitamin D3 tablets based on the therapy of the control group.The bone density of femur proximal Ward River,distal radius,first lumbar spine at hemi-plegia side of research time,the first month and the third month after the treatment in the two groups were detected and compared.Results There were no significant differences in bone density of the three tested sites of patients at the research time between the two groups (P >0.05),while at the first month and the third month after the treatment,the bone density of the patients in the observation group at the three sites were significantly higher than those in the control group (P <0.05).Conclusions The combined application of drugs and rehabilitation training to the patients with post-stroke hemiplegia can gain significant effect in prevention from the osteoporosis.
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Objective To explore the clinical effect of transurethral resection combined with intravesical mitomycin perfusionon in the treatment of cyslitis glandular (CG).Methods A total of 70 patients with CG in our hospital were randomly divided into control group (n =35)and obser-vation group (n =35).After transurethral resection,the control group was given pirarubicin hy-drochloride by perfusion of bladder,while the observation given pirarubicin hydrochloride combined with mitomycin by perfusion of bladder.The quality of life was evaluated by Quality of Life Scale in both groups,and clinical effects were compared.Results The difference was not significant though the overall response rate in observation group was slightly higher than that in the control group;The score of different items of quality of life in the obeservation group was evidently higher,but the inci-dence of adverse reactions was markedly lower in the observation group than that in the control group,and the differences was statistical significant.Conclusion Transurethral resection combined with intravesical mitomycin perfusion is effective in treating CG with low incidence of adverse reac-tions and high quality of life for patients,so it is worthy of being widely promoted in clinic.
Objective To explore the clinical effect of transurethral resection combined with intravesical mitomycin perfusionon in the treatment of cyslitis glandular (CG).Methods A total of 70 patients with CG in our hospital were randomly divided into control group (n =35)and obser-vation group (n =35).After transurethral resection,the control group was given pirarubicin hy-drochloride by perfusion of bladder,while the observation given pirarubicin hydrochloride combined with mitomycin by perfusion of bladder.The quality of life was evaluated by Quality of Life Scale in both groups,and clinical effects were compared.Results The difference was not significant though the overall response rate in observation group was slightly higher than that in the control group;The score of different items of quality of life in the obeservation group was evidently higher,but the inci-dence of adverse reactions was markedly lower in the observation group than that in the control group,and the differences was statistical significant.Conclusion Transurethral resection combined with intravesical mitomycin perfusion is effective in treating CG with low incidence of adverse reac-tions and high quality of life for patients,so it is worthy of being widely promoted in clinic.
2014, (5): 122-124.
DOI: 10.7619/jcmp.201405042
Abstract：
Objective To explore the effect of low dose sulfentanyl on labor analgesia. Methods 90 puerperas were randomly divided into observation group,control group I and control group Ⅱ,30 cases in each group.Sulfentanyl was used for labor analgesia in all the groups.The dose of sulfentanyl in the control group Ⅰ,the observation group and control group Ⅱ were 3 μg, 5 μg and 7μg respectively.Indexes such as analgesic efficacy,maternal birth outcomes,adverse re-actions and neonatal state were compared among three groups.Results The onset time of analge-sia in the control group Ⅰ was significantly longer than that in the observation group or the control group Ⅱ (P <0.05),while the first agent duration was significantly shorter than that in the ob-servation group or the control group Ⅱ (P <0.05);before the analgesia,there was no significant difference of VAS score among three groups (P >0.05);at the time of 30 and 60 minutes after analgesia,the VAS score of the control group I was significantly higher than that of the other two groups (P <0.05);there were no significant differences of the vaginal delivery rate,assistant vaginal delivery rate and cesarean section rate among the three groups (P >0.05);the incidence rates of the adverse reactions such as pruritus,nausea and vomiting,lethargy and fetal heart changes of the women in the control group Ⅰ and the observation group were significantly lower than those in the control group Ⅱ (P <0.05);the Apgar scores of the neonates in the control group Ⅰ and the observation group were significantly higher than that in the control group Ⅱ (P<0.05).Conclusion Efficacy of high or low dose sulfentanyl for labor analgesia is similar,while a very low dose sulfentanyl can not achieve the desired results.Compared with a high dose sulfen-tanyl,the adverse reactions probability induced by a low dose sufentanil is low and the neonatal state is better.
Objective To explore the effect of low dose sulfentanyl on labor analgesia. Methods 90 puerperas were randomly divided into observation group,control group I and control group Ⅱ,30 cases in each group.Sulfentanyl was used for labor analgesia in all the groups.The dose of sulfentanyl in the control group Ⅰ,the observation group and control group Ⅱ were 3 μg, 5 μg and 7μg respectively.Indexes such as analgesic efficacy,maternal birth outcomes,adverse re-actions and neonatal state were compared among three groups.Results The onset time of analge-sia in the control group Ⅰ was significantly longer than that in the observation group or the control group Ⅱ (P <0.05),while the first agent duration was significantly shorter than that in the ob-servation group or the control group Ⅱ (P <0.05);before the analgesia,there was no significant difference of VAS score among three groups (P >0.05);at the time of 30 and 60 minutes after analgesia,the VAS score of the control group I was significantly higher than that of the other two groups (P <0.05);there were no significant differences of the vaginal delivery rate,assistant vaginal delivery rate and cesarean section rate among the three groups (P >0.05);the incidence rates of the adverse reactions such as pruritus,nausea and vomiting,lethargy and fetal heart changes of the women in the control group Ⅰ and the observation group were significantly lower than those in the control group Ⅱ (P <0.05);the Apgar scores of the neonates in the control group Ⅰ and the observation group were significantly higher than that in the control group Ⅱ (P<0.05).Conclusion Efficacy of high or low dose sulfentanyl for labor analgesia is similar,while a very low dose sulfentanyl can not achieve the desired results.Compared with a high dose sulfen-tanyl,the adverse reactions probability induced by a low dose sufentanil is low and the neonatal state is better.
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Objective To observe the effect of Dexmedetomidine (DEX)on induction peri-od of hemodynamics in patients undergoing general anesthesia combined with epidural block.Meth-ods A total of 40 hysterectomy patients in optional period (ASA Ⅰ~Ⅱ)were randomly divided into Dexmedetomidine group(Group D)and Propofol group(P group).Group D received continuous epidural anesthesia with infusion of DEX 0.5 μg /(kg·h)and endotracheal intubation was applied after general anesthesia.Group P was given the same therapy with group D except dexmedetomi-dine.HR,SBP,DBP and MAP of the hemodynamic index were recorded at the time of entering the operation room(T1),after the determination of epidural plane(T2),pre-intubation(T3),intu-bation(T4),immediately after trachea intubation(T4),and the beginning of operation(T4).Results The difference was not statistically significant in the index between the two groups at T1 .HR of group D was lower than that in group P at all-time points(P <0.05).SBP,DBP and MAP of group D were higher than group P at T2,T3 and T4(P <0.05).SBP,DBP,MAP of group D were lower than group P at T5 and T6(P <0.05).SBP、DBP and MAP in group D at T2、T3 and T4 were higher than that in the group P (P <0.05).Conclusion Dexmedetomidine can offer a stable hemo-dynamics in the patients with general anesthesia combined with epidural block.
Objective To observe the effect of Dexmedetomidine (DEX)on induction peri-od of hemodynamics in patients undergoing general anesthesia combined with epidural block.Meth-ods A total of 40 hysterectomy patients in optional period (ASA Ⅰ~Ⅱ)were randomly divided into Dexmedetomidine group(Group D)and Propofol group(P group).Group D received continuous epidural anesthesia with infusion of DEX 0.5 μg /(kg·h)and endotracheal intubation was applied after general anesthesia.Group P was given the same therapy with group D except dexmedetomi-dine.HR,SBP,DBP and MAP of the hemodynamic index were recorded at the time of entering the operation room(T1),after the determination of epidural plane(T2),pre-intubation(T3),intu-bation(T4),immediately after trachea intubation(T4),and the beginning of operation(T4).Results The difference was not statistically significant in the index between the two groups at T1 .HR of group D was lower than that in group P at all-time points(P <0.05).SBP,DBP and MAP of group D were higher than group P at T2,T3 and T4(P <0.05).SBP,DBP,MAP of group D were lower than group P at T5 and T6(P <0.05).SBP、DBP and MAP in group D at T2、T3 and T4 were higher than that in the group P (P <0.05).Conclusion Dexmedetomidine can offer a stable hemo-dynamics in the patients with general anesthesia combined with epidural block.
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Objective To investigate bacterial vaginosis (BV)and vulvovaginal candidiasis (VVC)in women and to analyze its related factors.Methods The conditions of Physical examina-tion of 1967 female patients in the region from 2011 to 2013 were analyzed,and questionnaire was used to explore the relevant factors that affect the occurrence of BV and VVC.Results There were 282 patients with vulvovaginal yeast disease with the detection rate of 14.34%(282 /1967);231 patients were detected with bacterial vaginosis with 11.74% of detection rate (231 /1967);The higher detection rate of vulvovaginal candidiasis occurred among 25 to 35 year old and there was no significant difference in the occurrence of BV (P >0.05);Logistic analysis revealed that abortion was the risk factors that affect the treatment of VVC and BV;The man cooperated with the treatment and used condoms as protective factor as the safe factor.Conclusion VVC and BV are associated with vaginal microflora imbalance,so the patients should pay attention to healthy hy-giene habits as well as focus on treatment of the partners to block cross-infection and ensure good treatment effect.
Objective To investigate bacterial vaginosis (BV)and vulvovaginal candidiasis (VVC)in women and to analyze its related factors.Methods The conditions of Physical examina-tion of 1967 female patients in the region from 2011 to 2013 were analyzed,and questionnaire was used to explore the relevant factors that affect the occurrence of BV and VVC.Results There were 282 patients with vulvovaginal yeast disease with the detection rate of 14.34%(282 /1967);231 patients were detected with bacterial vaginosis with 11.74% of detection rate (231 /1967);The higher detection rate of vulvovaginal candidiasis occurred among 25 to 35 year old and there was no significant difference in the occurrence of BV (P >0.05);Logistic analysis revealed that abortion was the risk factors that affect the treatment of VVC and BV;The man cooperated with the treatment and used condoms as protective factor as the safe factor.Conclusion VVC and BV are associated with vaginal microflora imbalance,so the patients should pay attention to healthy hy-giene habits as well as focus on treatment of the partners to block cross-infection and ensure good treatment effect.
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Objective To explore the influence of low-dose sex hormone on bone mass loss for postmenopausal women.Methods A total of 85 postmenopausal women were randomly divided into group A,group B and group C.Group A (n =30)was given 1.0 mg estradiol valerate (E2V) and 2.0 mg medroxyprogesterone (MPA)every day.Group B (n =30)was conducted 0.45 mg conjugated estradiol (ethinylestradiol-3-cyclopentylether,CEE)and 2.0 mg MPA every day and group C (control group,n =25)was given vitamin (VitD)200 IU every day.The administration of drugs for each group was 12 months.In addition,400 mg elemental calcium was given daily to all women in the three groups.Bone mineral density (BMD)from the second to the fourth lumbar ver-tebra (L2-4),metabolic bone biochemical markers,urine N-telopeptide /creatinine (NTX /Cr)and incidence of bone fracture were observed before and after drug administration.Results After treat-ment of 12 months,BMD of L2 to L4 increased significantly in group B while it did not increased significantly in groups A and group C.After treatment for 6 months,urine NTX /Cr reduced in the 3 groups,in which the decreased range in group B was the most significant.The difference was sta-tistically significant in NTX /Cr value of group B and group C and there were no significant differ-ence in other groups.Conclusion Domestic E2V for 1 mg combined with 2 mg MPA every day can effectively prevent postmenopausal bone mass loss,and daily administration of CEE for 0.45 mg and MPA for 2 mg is favorable for most postmenopausal women.
Objective To explore the influence of low-dose sex hormone on bone mass loss for postmenopausal women.Methods A total of 85 postmenopausal women were randomly divided into group A,group B and group C.Group A (n =30)was given 1.0 mg estradiol valerate (E2V) and 2.0 mg medroxyprogesterone (MPA)every day.Group B (n =30)was conducted 0.45 mg conjugated estradiol (ethinylestradiol-3-cyclopentylether,CEE)and 2.0 mg MPA every day and group C (control group,n =25)was given vitamin (VitD)200 IU every day.The administration of drugs for each group was 12 months.In addition,400 mg elemental calcium was given daily to all women in the three groups.Bone mineral density (BMD)from the second to the fourth lumbar ver-tebra (L2-4),metabolic bone biochemical markers,urine N-telopeptide /creatinine (NTX /Cr)and incidence of bone fracture were observed before and after drug administration.Results After treat-ment of 12 months,BMD of L2 to L4 increased significantly in group B while it did not increased significantly in groups A and group C.After treatment for 6 months,urine NTX /Cr reduced in the 3 groups,in which the decreased range in group B was the most significant.The difference was sta-tistically significant in NTX /Cr value of group B and group C and there were no significant differ-ence in other groups.Conclusion Domestic E2V for 1 mg combined with 2 mg MPA every day can effectively prevent postmenopausal bone mass loss,and daily administration of CEE for 0.45 mg and MPA for 2 mg is favorable for most postmenopausal women.
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Objective To discuss the clinical influence of time of termination of pregnancy and method of delivery for pregnancy outcomes in pregnant patients with hypertension.Methods 156 pregnant patients with hypertension were divided into less than 34 weeks group with 22 pa-tients,34-36 weeks group with 41 patients,over 36 weeks group with 93 patients according to the time of the termination of pregnancy,and two groups including vaginal delivery group with 38 patients and cesarean section group with 118 patients according to delivery methods.The birth weight,neonatal asphyxia,neonatal mortality,maternal morbidity were contrasted between the three and two groups.Results The birth weight in the less than 34 weeks group were signifi-cantly lower than that the 34-36 weeks group and above 36 weeks group (P <0.01).The 34-36 weeks group was significantly lower than that in the above 36 weeks group(P <0.01).Neona-tal asphyxia and neonatal mortality in the less than 34 weeks group were significantly higher than that in the 34-36 weeks group and above 36 weeks group(P <0.01 or P <0.05).The 34-36 weeks group was significantly higher than that in the above 36 weeks group(P <0.05).But the difference was not significant in maternal morbidity in the three groups (P > 0 .0 5 ).The birth weight in the vaginal delivery group were significantly lower than that in the cesarean section group(P <0.01).And the neonatal asphyxia,neonatal mortality,and maternal morbidity in the vaginal delivery group were significantly higher than that in the cesarean section group (P <0.01).Conclusion Pregnancy patients with hypertension in shorter gestational time should be given reasonable treatment to extend pregnancy time.And they should terminate pregnancy at about 36 weeks of pregnancy and operate cesarean section to reduce the damage to the fetal.In this way,neonatal and maternal perinatal morbidity can reduce.
Objective To discuss the clinical influence of time of termination of pregnancy and method of delivery for pregnancy outcomes in pregnant patients with hypertension.Methods 156 pregnant patients with hypertension were divided into less than 34 weeks group with 22 pa-tients,34-36 weeks group with 41 patients,over 36 weeks group with 93 patients according to the time of the termination of pregnancy,and two groups including vaginal delivery group with 38 patients and cesarean section group with 118 patients according to delivery methods.The birth weight,neonatal asphyxia,neonatal mortality,maternal morbidity were contrasted between the three and two groups.Results The birth weight in the less than 34 weeks group were signifi-cantly lower than that the 34-36 weeks group and above 36 weeks group (P <0.01).The 34-36 weeks group was significantly lower than that in the above 36 weeks group(P <0.01).Neona-tal asphyxia and neonatal mortality in the less than 34 weeks group were significantly higher than that in the 34-36 weeks group and above 36 weeks group(P <0.01 or P <0.05).The 34-36 weeks group was significantly higher than that in the above 36 weeks group(P <0.05).But the difference was not significant in maternal morbidity in the three groups (P > 0 .0 5 ).The birth weight in the vaginal delivery group were significantly lower than that in the cesarean section group(P <0.01).And the neonatal asphyxia,neonatal mortality,and maternal morbidity in the vaginal delivery group were significantly higher than that in the cesarean section group (P <0.01).Conclusion Pregnancy patients with hypertension in shorter gestational time should be given reasonable treatment to extend pregnancy time.And they should terminate pregnancy at about 36 weeks of pregnancy and operate cesarean section to reduce the damage to the fetal.In this way,neonatal and maternal perinatal morbidity can reduce.
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Objective To explore the safety and efficacy of low molecular heparin in the treatment of full-term pregnant women with pathological hypercoagulabale stage.Methods 160 pregnant women with over standard level of D-dimer were divided into treatment group and con-trol group,80 cases in each group.The treatment group was treated with low molecular heparin calcium 4 100 U by subcutaneous injection once per day,7 days were considered as a course of treatment.The control group was not conducted with anticoagulant therapy.Coagulation function, D-dimers and blood routine,pregnancy and perinatal outcome were monitored at the time points of 7 days after application of low molecular heparin and two days after spontaneous delivery or oper-ation.Results Low molecular heparin could significantly improve hematological hypercoagulabale stage,and it is able to make the perinatal pathological hypercoagulabale stage transform to normal hypercoagulabale stage in order to reduce the incidence rate of VTE and DIC.Conclusion Low molecular heparin can prevent and treat the perinatal pathological hypercoagulabale stage effectively in full-term pregnant women,so it is worthy of clinical application.
Objective To explore the safety and efficacy of low molecular heparin in the treatment of full-term pregnant women with pathological hypercoagulabale stage.Methods 160 pregnant women with over standard level of D-dimer were divided into treatment group and con-trol group,80 cases in each group.The treatment group was treated with low molecular heparin calcium 4 100 U by subcutaneous injection once per day,7 days were considered as a course of treatment.The control group was not conducted with anticoagulant therapy.Coagulation function, D-dimers and blood routine,pregnancy and perinatal outcome were monitored at the time points of 7 days after application of low molecular heparin and two days after spontaneous delivery or oper-ation.Results Low molecular heparin could significantly improve hematological hypercoagulabale stage,and it is able to make the perinatal pathological hypercoagulabale stage transform to normal hypercoagulabale stage in order to reduce the incidence rate of VTE and DIC.Conclusion Low molecular heparin can prevent and treat the perinatal pathological hypercoagulabale stage effectively in full-term pregnant women,so it is worthy of clinical application.
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