Advance Search
WU Guohua, ZHANG Xiaofei, WANG Qi, LI Chao, YAN Xuefang. Relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 58-62. DOI: 10.7619/jcmp.20240835
Citation: WU Guohua, ZHANG Xiaofei, WANG Qi, LI Chao, YAN Xuefang. Relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 58-62. DOI: 10.7619/jcmp.20240835
shu

Relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke

  • 1.

    CT/MRI Room, Handan Central Hospital in Hebei Province, Handan, Hebei, 056008

  • 2.

    the First Department of Geriatrics, Handan Central Hospital in Hebei Province, Handan, Hebei, 056008

More Information
  • Received Date: February 29, 2024
  • Revised Date: May 10, 2024
  • Available Online: July 19, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To analyze the relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke.

    Methods 

    A total of 240 elderly patients with ischemic stroke were selected as observation group, and were further divided into different groups based on disease classification [complete anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), posterior circulation infarction (POCI), lacunar infarction (LACI)] and severity of the disease (mild, moderate, and severe); another 60 elderly healthy individuals with physical examinations were selected as control group. The characteristics of carotid artery plaques [carotid intima-media thickness (IMT), number of plaques, maximum length of plaques, and nature of plaques]as well as hemorheology indexes[erythrocyte sedimentation rate (ESR), hematocrit (HCT), plasma fibrinogen (Fib), plasma viscosity, and whole blood viscosity]were measured in all the cases, and the relationships of carotid plaque characteristics and hemorheology with disease classification and severity were analyzed.

    Results 

    The IMT, the number of plaques, maximum diameter of plaques, ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the observation group were significantly higher than those in the control group (P < 0.05); the IMT, the number of plaques, and maximum diameter of plaques in the LACI group were significantly lower than those in the TACI, PACI, and POCI groups, while the ratios of stable plaques were significantly higher (P < 0.05); the ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the LACI group were significantly lower than those in the TACI, PACI, and POCI groups (P < 0.05); the IMT, the number of plaques, and maximum diameter of plaques in the mild group were significantly lower than those in the moderate and severe groups, the ratio of stable plaques was significantly higher than that in the moderate and severe groups, the IMT, the number of plaques, and maximum diameter of plaques in the moderate group were significantly lower than those in the severe group (P < 0.05); the ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the mild group were significantly lower than those in the moderate and severe groups, and the above indicators in the moderate group were significantly lower than those in the severe group (P < 0.05).

    Conclusion 

    The characteristics of carotid artery plaques and hemorheology in elderly patients with ischemic stroke are related to the classification and severity of the disease, and the status of carotid artery plaques and hemorheological abnormalities in elderly patients with TACI, PACI, and POCI types of ischemic stroke are more severe than those of patients with LACI type.

    • FullText(HTML)
    • References (20)
  • [1]
    林巧茂, 李阔, 项宁, 等. 血清可溶性髓系细胞触发受体-1与老年急性缺血性脑卒中严重程度及预后的关系[J]. 实用老年医学, 2022, 8(8): 827-832. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLA202208018.htm
    [2]
    衣丽华, 董岩, 郑丽莎, 等. 血清MASP-3、MBL、SDMA对老年急性缺血性脑卒中的诊断价值[J]. 疑难病杂志, 2022, 8(5): 456-460, 474.
    [3]
    杜立铭, 郭林霞, 刘银芳. 老年急性缺血性脑卒中患者外周血中解聚蛋白样金属蛋白酶-4表达水平与颈动脉斑块不稳定和患者预后的关系[J]. 卒中与神经疾病, 2022, 8(3): 205-209.
    [4]
    孙丹丹, 陈怡静, 霍禹璇, 等. 颈动脉斑块超声特征与中老年患者缺血性脑卒中的关联性研究[J]. 解放军医学院学报, 2022, 43(1): 15-19.
    [5]
    刘明全, 杨敏, 黄飞, 等. 老年2型糖尿病伴脑梗死患者血液流变学及凝血功能指标检测及意义[J]. 海南医学院学报, 2018, 24(1): 125-128.
    [6]
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJB201911024.htm
    [7]
    张鹏. 脑卒中患者TOAST、OCSP分型与外周血DNA甲基转移酶及MeCp2蛋白水平的关系[J]. 检验医学与临床, 2023, 9(8): 1160-1164.
    [8]
    王峰. 血清脂蛋白相关磷脂酶A2、同型半胱氨酸、胱抑素C水平与急性脑梗死及其神经功能缺损程度、短期预后的关系研究[J]. 实用心脑肺血管病杂志, 2019, 27(6): 24-29.
    [9]
    ALTERSBERGER V L, RUSCHE N, MARTINEZ-MAJANDER N, et al. Intravenous thrombolysis in patients with ischemic stroke aged ≥90 years: a cohort study from the TRISP collaboration[J]. Stroke, 2022, 53(12): 3557-3563.
    [10]
    张艾嘉, 王爽, 王萍, 等. 缺血性脑卒中的病理机制研究进展及中医药防治[J]. 中国实验方剂学杂志, 2020, 26(5): 227-240. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202005033.htm
    [11]
    吴勇, 吴应林, 汪声奎. 银杏内酯注射液辅助治疗老年缺血性脑卒中的疗效及对患者神经功能和预后的影响[J]. 河北医药, 2020, 42(15): 2291-2295.
    [12]
    黄欣, 黄婷, 李娜, 等. 血管内支架介入成形术对老年缺血性脑卒中患者的神经功能及预后的影响[J]. 空军医学杂志, 2019, 35(6): 499-502.
    [13]
    CHEN X J, XIE Y D, LIANG C L, et al. Tug1 acts on ERK12 signaling pathway to aggravate neuronal damage after acute ischemic stroke[J]. Cell Mol Biol, 2022, 68(1): 51-58.
    [14]
    康钦, 王豪, 宋嫣, 等. 彩色多普勒超声检测颈动脉内中膜厚度、斑块及颈动脉狭窄对缺血性脑卒中的诊断价值[J]. 实用临床医药杂志, 2019, 23(14): 43-45.
    [15]
    于洪远, 景淑贤, 景倩. 血栓分子标志物与急性缺血性脑卒中病情严重程度及溶栓预后的相关性[J]. 现代生物医学进展, 2023, 23(8): 1506-1510.
    [16]
    吕康, 孔伟丽, 付广, 等. 银杏叶提取物注射液联合阿加曲班治疗急性脑梗死的临床研究[J]. 现代药物与临床, 2023, 9(3): 596-601.
    [17]
    臧卫平, 张志军, 封倩, 等. 盐酸氟西汀联合三七通舒胶囊对缺血性脑卒中老年患者NIHSS评分及血清CGRP、IGF-1水平的影响[J]. 中国老年学杂志, 2021, 41(19): 4178-4181.
    [18]
    苏健, 徐冰, 宋媛, 等. 脑梗死患者血清炎性因子、同型半胱氨酸与颈动脉内膜中层厚度的关系[J]. 检验医学, 2020, 35(8): 852-853. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202008028.htm
    [19]
    苗亚南. 调脂汤对急性脑梗死患者血液流变学及颈动脉粥样硬化斑块的影响[J]. 新中医, 2022, 8(3): 56-60. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202203011.htm
    [20]
    徐军鹏, 胡国豪, 黄方剑. 老年急性缺血性脑卒中患者疾病分型和严重程度与颈动脉斑块性质和血液流变学的关系[J]. 中国现代医学杂志, 2019, 29(22): 108-112.
    • Related Articles

  • Related Articles

    [1]REN Ke, TIAN Lijun, HUANG Xiaoying, HAN Xudong, ZHANG Ying. Value of indicators including serum neuron-specific enolase in assessing prognosis of patients with cirrhosis complicated by overt hepatic encephalopathy[J]. Journal of Clinical Medicine in Practice, 2024, 28(17): 35-40. DOI: 10.7619/jcmp.20241108
    [2]WANG Hongfang, LI Shuhua, ZHANG Runchun, ZHANG Yanbo. Changes of cellular inflammatory factors, immune levels, myelin basic protein and neuron-specific enolase levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 54-57, 62. DOI: 10.7619/jcmp.20211644
    [3]YU Xiaochen, Yimamu YIDAYITULA, CAI Ning, ZHANG Yonghui. Dynamic changes of serum neuron-specific enolase in patients with single traumatic subarachnoid hemorrhage and its value in predicting prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 8-12. DOI: 10.7619/jcmp.20201422
    [4]FANG Sisi, LUO Lan, ZHOU Haiyin, LONG Caixia. Levels of neuron-specific enolase, myelin basic protein, S-100 protein and their clinical significance in children with viral encephalitis[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 89-91,95. DOI: 10.7619/jcmp.202017024
    [5]WANG Ying, LIU Min. Value of video electroencephalogram combined with neuron specific enolase detection in the diagnosis of children with febrile convulsions[J]. Journal of Clinical Medicine in Practice, 2020, 24(9): 10-12. DOI: 10.7619/jcmp.202009003
    [6]XUE Yafei, JING Yunyun, ZHANG Yufu. Levels of serum thrombospondin1/2, neuron-specific enolase and S-100β before and after trepanation and drainage in chronic subdural hematoma and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(1): 58-61. DOI: 10.7619/jcmp.202001015
    [7]JIA Shujing, SHI Chunxia, LI Lihua. Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors[J]. Journal of Clinical Medicine in Practice, 2019, 23(10): 61-64. DOI: 10.7619/jcmp.201910017
    [8]MA Tianming, HAN Xianwei. Change and significance of serum neuron specific enolase level in patients with herpes zoster[J]. Journal of Clinical Medicine in Practice, 2017, (13): 100-102. DOI: 10.7619/jcmp.201713026
    [9]QIU Zhenqin, WANG Bingqiong. Influence of general anesthesia with propofol on serum neuron specific enolase and S100B protein levels and cognitive function in elderly patients[J]. Journal of Clinical Medicine in Practice, 2016, (1): 39-41,55. DOI: 10.7619/jcmp.201601012
    [10]GUO Li-ru, LIU Qing-rui, CHEN Jin-hu. Changes of lysophosphatidic acid, Neuron specific enolase and fibrinogen in patients with progressive cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2010, (15): 17-19,27. DOI: 10.3969/j.issn.1672-2353.2010.15.005

  • Cited by

    Periodical cited type(3)

    1. 赵秀芬，杨名钫，程思思，曾超男，胡秋兰，杨丽珠. E-Coach慢病管理模式在根治性前列腺切除术患者中的应用. 卫生职业教育. 2024(19): 152-156 .
    2. 汤爱玲，许方蕾. 腹腔镜前列腺癌根治术患者出院准备度预警模型的构建. 实用临床医药杂志. 2023(20): 16-20+25 . 本站查看
    3. 张笑，孙健，丁锡奇. 腹腔镜前列腺癌根治术治疗早期前列腺癌对雄激素水平及术后尿失禁发生率的影响. 国际医药卫生导报. 2022(18): 2583-2586 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (123) PDF downloads (9) Cited by(3)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return