Advance Search
WANG Hongfang, LI Shuhua, ZHANG Runchun, ZHANG Yanbo. Changes of cellular inflammatory factors, immune levels, myelin basic protein and neuron-specific enolase levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 54-57, 62. DOI: 10.7619/jcmp.20211644
Citation: WANG Hongfang, LI Shuhua, ZHANG Runchun, ZHANG Yanbo. Changes of cellular inflammatory factors, immune levels, myelin basic protein and neuron-specific enolase levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 54-57, 62. DOI: 10.7619/jcmp.20211644
shu

Changes of cellular inflammatory factors, immune levels, myelin basic protein and neuron-specific enolase levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis and their clinical significance

  • 1.

    Department of Pediatric Internal Medicine, Tangshan Maternal and Child Health Hospital in Hebei Province, Tangshan, Hebei, 063000

  • 2.

    Department of Pediatric Internal Medicine, Qinhuangdao Second Hospital in Hebei Province, Qinhuangdao, Hebei, 066000

More Information
  • Received Date: April 18, 2021
  • Available Online: June 14, 2021
  • Published Date: June 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the changes of cellular inflammatory cytokines, immune levels, myelin basic protein (MBP) and neuron-specific enolase (NSE) levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis (BICE) and their clinical significance.
      Methods  Forty-two children with BICE were selected as the observation group, and the children in the observation group were divided into group A and group B according to the frequency of convulsion. A total of 18 cases in group A had convulsion less than 2 times, 24 cases in group B had convulsion 2 times and above, and 42 children with mild gastroenteritis without convulsion were selected as the control group. Cellular inflammatory cytokines, immune levels, MBP and NSE levels in cerebrospinal fluid were observed in each group.
      Results  The levels of tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ) and interleukin-6 (IL-6) in the observation group were significantly higher than those in control group, and the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group (P < 0.05). The levels of TNF-α, IL-6 and INF-γ in the group B were significantly higher than those in the group A, and the levels of CD3+, CD4+ and CD4+/CD8+ in the group B were significantly lower than those in the group A (P < 0.05). The levels of S-100β protein (S-100β) and NSE in cerebrospinal fluid in the group B were significantly higher than those in the group A (P < 0.05).
      Conclusion  In the process of seizures in children with BICE, it is of great clinical value to observe the changes of cellular inflammatory cytokines, immune levels and the levels of MBP and NSE in cerebrospinal fluid, so as to understand the physical conditions of the children and facilitate the screening of high-risk children and the formulation of related prevention and treatment measures.
    • FullText(HTML)
    • References (24)
  • [1]
    CHEN H, ZHA J, ZHONG J M, et al. Clinical features of Campylobacter-associated benign convulsions with mild gastroenteritis compared with Rotavirus convulsions[J]. Seizure, 2019, 70: 20-24. doi: 10.1016/j.seizure.2019.06.010
    [2]
    方玉红, 崔晓明, 徐拥军, 等. 感染轻度胃肠炎伴婴幼儿良性惊厥临床特点及预后分析[J]. 中华医院感染学杂志, 2017, 27(23): 5476-5479. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201723052.htm
    [3]
    美丽, 图雅. 轻度胃肠炎伴婴幼儿良性惊厥发病机制的研究进展[J]. 医学综述, 2019, 25(4): 733-737. doi: 10.3969/j.issn.1006-2084.2019.04.020
    [4]
    苏慧霞. 婴幼儿急性胃肠炎伴良性惊厥临床分析及远期随访观察[J]. 儿科药学杂志, 2017, 23(7): 32-34. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX201707012.htm
    [5]
    KIM B R, CHOI G E, KIM Y O, et al. Incidence and characteristics of Norovirus-associated benign convulsions with mild gastroenteritis, in comparison with Rotavirus ones[J]. Brain Dev, 2018, 40(8): 699-706. doi: 10.1016/j.braindev.2018.04.001
    [6]
    卢乐声, 徐智芳, 白星, 等. 轻度胃肠炎伴良性婴幼儿惊厥肠道微生物改变的研究[J]. 中华全科医学, 2018, 16(5): 802-804. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201805036.htm
    [7]
    李素丽, 周方, 李小芹. 轻度胃肠炎伴婴幼儿良性惊厥的临床特点及预后分析[J]. 《国际医药卫生导报》, 2019, 25(16): 2636-2638. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201723052.htm
    [8]
    陈豪, 潘阳琼, 张香敏, 等. 轻度胃肠炎伴婴幼儿良性惊厥111例临床分析及远期随访研究[J]. 中华全科医学, 2018, 16(12): 2042-2044, 2076. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201812026.htm
    [9]
    李睿, 佟建宁. 轮状病毒肠炎合并良性惊厥研究进展[J]. 大连医科大学学报, 2018, 40(3): 274-277. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201803022.htm
    [10]
    张丽媛, 李芙蓉, 弓伊宁, 等. 免疫功能正常儿童患巨细胞病毒胃肠炎系统评价[J]. 中国实用儿科杂志, 2020, 35(4): 301-306. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK202004015.htm
    [11]
    陈雨晴, 刘安元, 吴移谋. 抗衣原体感染Th1/Th2细胞免疫应答的研究进展[J]. 细胞与分子免疫学杂志, 2018, 34(12): 1136-1140. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201812017.htm
    [12]
    吴念轩, 严晨曦, 傅瑶. 外泌体在机体免疫调节中的作用与研究进展[J]. 细胞与分子免疫学杂志, 2018, 34(3): 273-277. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201803016.htm
    [13]
    张鸿光. 结直肠癌患者行腹腔镜根治术效果观察及对炎性反应和应激反应的影响[J]. 中国医师进修杂志, 2021, 44(02): 179-183. doi: 10.3760/cma.j.cn115455-20200813-01065
    [14]
    王中秀, 陈莉丽. 辅助性T细胞1和17特征性分泌因子干扰素γ及白细胞介素17在牙周炎发生发展中作用的研究进展[J]. 中华口腔医学杂志, 2019, 54(6): 420-424. doi: 10.3760/cma.j.issn.1002-0098.2019.06.015
    [15]
    美丽, 图雅, 高鑫, 等. 轻度胃肠炎伴婴幼儿良性惊厥病原学及血清炎症因子分析[J]. 中国医师杂志, 2020, 22(8): 1143-1147. doi: 10.3760/cma.j.cn431274-20190705-00797
    [16]
    段炤, 林智平, 刘青, 等. CD4+CD25+调节性T淋巴细胞与辅助性T淋巴细胞17在川崎病发病机制中的作用[J]. 中华实用儿科临床杂志, 2017, 32(9): 652-655. doi: 10.3760/cma.j.issn.2095-428X.2017.09.004
    [17]
    卢灵莉, 张伟锋, 陈华林. T淋巴细胞、血清炎症因子与胃肠炎伴良性惊厥的相关性[J]. 儿科药学杂志, 2016, 22(9): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-EKYX201609001.htm
    [18]
    卢一斌, 刘占利, 马效东. NLR和RDW在小儿高热惊厥中的表达及其与T淋巴细胞水平的相关性研究[J]. 重庆医学, 2019, 48(17): 2953-2955, 2959. doi: 10.3969/j.issn.1671-8348.2019.17.017
    [19]
    聂娜娜, 林毅, 毛成刚, 等. 川崎病患儿外周血细胞因子转导抑制因子1、3 mRNA表达及辅助性T淋巴细胞、CD4+ CD25+调节性T淋巴细胞的变化[J]. 中华实用儿科临床杂志, 2015, 30(21): 1652-1655. doi: 10.3760/cma.j.issn.2095-428X.2015.21.015
    [20]
    卢秀花, 陈忠光, 王彦丽. 地锦草片对免疫性血小板减少症患者T淋巴细胞亚群及细胞因子的影响[J]. 中成药, 2017, 39(1): 50-54. doi: 10.3969/j.issn.1001-1528.2017.01.009
    [21]
    何金婷, 李晓炎, 邱培森, 等. S100B与神经系统疾病相关性研究进展[J]. 中国实验诊断学, 2019, 23(9): 1650-1654. doi: 10.3969/j.issn.1007-4287.2019.09.057
    [22]
    李芹, 王亚坤, 田利远, 等. 髓鞘碱性蛋白、神经元特异性烯醇化酶在支原体肺炎并发脑炎患儿中的临床研究[J]. 中国儿童保健杂志, 2019, 27(2): 202-204. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO201902024.htm
    [23]
    冯悦, 张真稳, 朱妍. 神经元特异性烯醇化酶与糖尿病微血管病变关系的研究进展[J]. 医学综述, 2017, 23(10): 1980-1984. doi: 10.3969/j.issn.1006-2084.2017.10.023
    [24]
    陈俊国, 吴鸣, 张旭, 等. 轻度胃肠炎伴婴幼儿良性惊厥患儿脑脊液中S-100β蛋白、MBP、NSE变化的相关性研究[J]. 中华全科医学, 2017, 15(6): 986-988. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201706025.htm
    • Related Articles

  • Related Articles

    [1]LI Juan, ZHANG Le, CHEN Weiqiang. Correlations of cerebrospinal fluid CTHRC1 and OLFM3 levels with cognitive impairment and cerebrospinal fluid biomarkers in patients with Alzheimer′s disease[J]. Journal of Clinical Medicine in Practice, 2025, 29(1): 50-55. DOI: 10.7619/jcmp.20242462
    [2]ZENG Dong, SUN Wenwen, CHEN Guanghui, WANG Zhenzhen. Value of combined detection of cerebrospinal fluid lactate, interleukin-27 and interferon-γ in diagnosing bacterial meningitis after neurosurgical operation[J]. Journal of Clinical Medicine in Practice, 2024, 28(2): 23-27. DOI: 10.7619/jcmp.20232483
    [3]DU Kaixian, HU Huihui, LI Lin, DONG Yan, GUAN Jing, SONG Chunlan, BAI Yanmin, KONG Lina, JIA Tianming. Value of fibronectin, vascular endothelial growth factor and lactate dehydrogenas levels in cerebrospinal fluid in diagnosing bacterial meningitis and viral encephalitis in children[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 26-30. DOI: 10.7619/jcmp.20210272
    [4]FANG Sisi, LUO Lan, ZHOU Haiyin, LONG Caixia. Levels of neuron-specific enolase, myelin basic protein, S-100 protein and their clinical significance in children with viral encephalitis[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 89-91,95. DOI: 10.7619/jcmp.202017024
    [5]SHI Fengquan, QIU Hongsheng, LI Wenzhong, DING Kewen, FENG Xufen, PAN Zhangying, LI Lili, QIU Jianwen, LIU Xuewu. Correlations between severity of neonatal hypoxic ischemic encephalopathy and levels of arterial blood lactic acid as well as cerebrospinal fluid lactic acid[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 86-88. DOI: 10.7619/jcmp.202017023
    [6]DOU Limin, LI Dongru, WANG Dong, ZHENG Yongke, DONG Xiaoqiao, YU Wenhua, DAI Wei, LI Jie, ZHANG Danglin. Effect of early clearance of bloody cerebrospinal fluid on the prognosis of patients with severe brain injury surgery[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 61-64. DOI: 10.7619/jcmp.201918018
    [7]WANG Jun, ZHENG Shouchao, LIU Xiaohui, GAO Sunxing, TIAN Weirong, HAN Qinglin. Effect comparison between cerebrospinal fluid leakage using various deep fascia continuous suture techniques and interrupted suture in lumbar posterior surgery[J]. Journal of Clinical Medicine in Practice, 2017, (24): 30-33. DOI: 10.7619/jcmp.201724009
    [8]XIE Fengju. Nursing measures of patients with cerebrospinal fluid leakage after spinal surgery[J]. Journal of Clinical Medicine in Practice, 2017, (6): 97-100. DOI: 10.7619/jcmp.201706030
    [9]XU Daxing, LI Sen, LI Yanjie, CHEN Linlin, WU Hao. Changes and significance of lactate dehydrogenase, adenosine deaminase and tumor necrosis factor-α in cerebrospinal fluid of patients with viral meningitis[J]. Journal of Clinical Medicine in Practice, 2016, (24): 26-28. DOI: 10.7619/jcmp.201624007
    [10]GUO Gaiyan, DONG Zhiyan. Expression of miRNA-184 in serum and cerebrospinal fluid of patients with epilepsy[J]. Journal of Clinical Medicine in Practice, 2015, (1): 142-144. DOI: 10.7619/jcmp.201501047

  • Cited by

    Periodical cited type(3)

    1. 侯蒙蒙，刘亚利. 术前盐酸戊乙奎醚预处理在腹腔镜子宫全切术中的应用分析. 华夏医学. 2024(01): 116-121 .
    2. 刘焰，李国妍，陈超. 利多卡因对脑胶质瘤细胞恶性生物学行为的影响. 湖南师范大学学报(医学版). 2024(03): 16-21 .
    3. 张艳锋，张岚，韩辉. 银杏叶片联合利多卡因治疗周围性眩晕的临床效果及对患者情绪与前庭功能的影响. 临床合理用药杂志. 2022(32): 15-18 .

    Other cited types(3)

Catalog

    Get Citation
    PDF
    XML
    Article views (456) PDF downloads (10) Cited by(6)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return