Objective To investigate the changes of cellular inflammatory cytokines, immune levels, myelin basic protein (MBP) and neuron-specific enolase (NSE) levels in cerebrospinal fluid in children with benign infantile convulsions with mild gastroenteritis (BICE) and their clinical significance.
Methods Forty-two children with BICE were selected as the observation group, and the children in the observation group were divided into group A and group B according to the frequency of convulsion. A total of 18 cases in group A had convulsion less than 2 times, 24 cases in group B had convulsion 2 times and above, and 42 children with mild gastroenteritis without convulsion were selected as the control group. Cellular inflammatory cytokines, immune levels, MBP and NSE levels in cerebrospinal fluid were observed in each group.
Results The levels of tumor necrosis factor-α (TNF-α), interferon-γ (INF-γ) and interleukin-6 (IL-6) in the observation group were significantly higher than those in control group, and the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group (P < 0.05). The levels of TNF-α, IL-6 and INF-γ in the group B were significantly higher than those in the group A, and the levels of CD3+, CD4+ and CD4+/CD8+ in the group B were significantly lower than those in the group A (P < 0.05). The levels of S-100β protein (S-100β) and NSE in cerebrospinal fluid in the group B were significantly higher than those in the group A (P < 0.05).
Conclusion In the process of seizures in children with BICE, it is of great clinical value to observe the changes of cellular inflammatory cytokines, immune levels and the levels of MBP and NSE in cerebrospinal fluid, so as to understand the physical conditions of the children and facilitate the screening of high-risk children and the formulation of related prevention and treatment measures.
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