Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors

JIA Shujing; SHI Chunxia; LI Lihua

doi:10.7619/jcmp.201910017

Journal of Clinical Medicine in Practice > 2019 > 23(10): 61-64. > DOI: 10.7619/jcmp.201910017

JIA Shujing, SHI Chunxia, LI Lihua. Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors[J]. Journal of Clinical Medicine in Practice, 2019, 23(10): 61-64. DOI: 10.7619/jcmp.201910017

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Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors

1.
General Medical Department, Yongle Town Community Health Center of Tongzhou District in Beijing, Beijing, 101105
2.
Department of Nephrology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, 101149

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Received Date: March 14, 2019
Accepted Date: April 19, 2019
Available Online: February 22, 2021
Published Date: May 27, 2019

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Abstract

Abstract

Objective To explore clinical significance and changes of serum high-sensitivity C reactive protein (hs-CRP) and neuron-specific enolase (NSE) in acute cerebral infarction (ACI) patients with different risk factors.
Methods Totally 20 healthy people and 68 patients with ACI were selected, and the ACI patients were divided into simple ACI group, ACI plus hypertension group and ACI plus diabetes group according to risk factors. The serum levels of hs-CRP and NSE were measured by ELISA, and the changes of hs-CRP and NSE in cerebral infarction patients with different risk factors were compared. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity of neurological deficits.
Results The serum hs-CRP and NSE levels in ACI patients were significantly higher than those in control group at adnission (P < 0.01). In ACI patients, the serum hs-CRP and NSE levels in ACI plus hypertension group and ACI plus diabetes group were significantly higher than those in simple ACI group (P < 0.05). Serum hs-CRP and NSE levels in ACI patients were positively correlated with NIHSS scores. Pearson correlation analysis showed that serum hs-CRP level was positively correlated with NSE level in ACI patients (P < 0.05).
Conclusion Acute cerebral infarction patients may suffer more serious aggravate vasculitis and neurological impairment when complicated with hypertension and diabetes.

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References

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Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors