Research hotspots and trends in ketogenic diet from 2013 to 2022 based on the Web of Science database

GAO Mingbo; HAN Ting

doi:10.7619/jcmp.20233347

Journal of Clinical Medicine in Practice > 2024 > 28(5): 68-74. > DOI: 10.7619/jcmp.20233347

GAO Mingbo, HAN Ting. Research hotspots and trends in ketogenic diet from 2013 to 2022 based on the Web of Science database[J]. Journal of Clinical Medicine in Practice, 2024, 28(5): 68-74. DOI: 10.7619/jcmp.20233347

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Research hotspots and trends in ketogenic diet from 2013 to 2022 based on the Web of Science database

GAO Mingbo,
HAN Ting^,

Department of Clinical Nutrition, the Tenth People's Hospital Affiliated to Tongji University, Shanghai Clinical Nutrition Quality Control Center, Shanghai, 200072

More Information

Received Date: October 21, 2023
Revised Date: January 08, 2024
Available Online: March 21, 2024

Graphical Abstract

Abstract

Abstract

Objective
To analyze the literature related to ketogenic diet based on the Web of Science (WOS) database and clarify the research hotspots and trends in this field.
Methods
The literature related to ketogenic diet was retrieved from the core database of WOS from January 1, 2013 to December 31, 2022. Bibliometric methods and CiteSpace software were applied to statistically analyze the literature characteristics, including countries, regions, research institutions, publishing journals, and keywords.
Results
A total of 4, 548 valid articles were retrieved in this study, including 3, 317 original articles and 1, 231 reviews. The number of publications in the field of ketogenic diet research showed an overall increasing trend from 2013 to 2022, reaching the peak in 2021(756 articles). The annual citation frequency also exhibited a yearly increasing trend, reaching a peak of 25, 643 citations in 2022. The country with the highest number of publications was the United States (1, 695 articles, accounting for 37.27%), and the research institution with the most articles was Johns Hopkins University (88 articles, accounting for 1.93%). The majority of research institutions were universities. Nutrients journal had the highest number of published articles (241 articles, accounting for 5.30%), while Epilepsia journal had the highest average citation frequency per article (33.19 citations). Among the top 10 most cited articles, five focused on the metabolism and mechanism of action of ketone bodies in disease treatment, and four were related to epilepsy research. The research hotspots included the application and efficacy evaluation of ketogenic diet in the treatment of epilepsy and obesity, common regulatory mechanisms such as fatty acid oxidation, metabolism, oxidative stress, and Warburg effect of ketone bodies, and the role of gut microbiota in mediating the effects of ketogenic diet. The research trend pointed towards the application prospects of ketogenic diet in heart failure.
Conclusion
Ketogenic diet has been applied in the treatment of various diseases, and its global attention continues to grow. Future research hotspots should focus on clinical trials to verify its clinical efficacy and tolerability.
- ketogenic diet,
- Web of Science,
- visual analysis,
- bibliometrics,
- epilepsy,
- obesity

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References (32)

References

[1]	WHELESS J W. History of the ketogenic diet[J]. Epilepsia, 2008, 49(Suppl 8): 3-5.
[2]	GUPTA L, KHANDELWAL D, KALRA S, et al. Ketogenic diet in endocrine disorders: current perspectives[J]. J Postgrad Med, 2017, 63(4): 242-251. doi: 10.4103/jpgm.JPGM_16_17
[3]	朱思源, 王安东, 严雪冰. 生酮饮食在疾病治疗中的研究进展[J]. 实用临床医药杂志, 2022, 26(20): 142-148. doi: 10.7619/jcmp.20221397
[4]	郭琴, 孙萍. 生酮饮食对超重/肥胖病人影响效果的Meta分析[J]. 安徽医药, 2022, 26(11): 2187-2193. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYY202211016.htm
[5]	江波. 生酮饮食在肿瘤治疗中的应用[J]. 实用临床医药杂志, 2019, 23(14): 1-6. doi: 10.7619/jcmp.201914001
[6]	江波, 邹大进, 马向华, 等. 生酮饮食干预2型糖尿病中国专家共识(2019年版)[J]. 实用临床医药杂志, 2019, 23(3): 1-6. doi: 10.7619/jcmp.201903001
[7]	CHEN C M. CiteSpace Ⅱ: detecting and visualizing emerging trends and transient patterns in scientific literature[J]. J Am Soc Inf Sci Technol, 2006, 57(3): 359-377. doi: 10.1002/asi.20317
[8]	HARTMAN A L, STAFSTROM C E. Harnessing the power of metabolism for seizure prevention: focus on dietary treatments[J]. Epilepsy Behav, 2013, 26(3): 266-272. doi: 10.1016/j.yebeh.2012.09.019
[9]	NEI M, NGO L, SIRVEN J I, et al. Ketogenic diet in adolescents and adults with epilepsy[J]. Seizure, 2014, 23(6): 439-442. doi: 10.1016/j.seizure.2014.02.015
[10]	WELLS J, SWAMINATHAN A, PASEKA J, et al. Efficacy and safety of a ketogenic diet in children and adolescents with refractory epilepsy-a review[J]. Nutrients, 2020, 12(6): 1809. doi: 10.3390/nu12061809
[11]	POORSHIRI B, BARZEGAR M, TAHMASEBI S, et al. The efficacy comparison of classic ketogenic diet and modified Atkins diet in children with refractory epilepsy: a clinical trial[J]. Acta Neurol Belg, 2021, 121(2): 483-487. doi: 10.1007/s13760-019-01225-0
[12]	BARZEGAR M, AFGHAN M, TARMAHI V, et al. Ketogenic diet: overview, types, and possible anti-seizure mechanisms[J]. Nutr Neurosci, 2021, 24(4): 307-316. doi: 10.1080/1028415X.2019.1627769
[13]	AUVIN S. Non-pharmacological medical treatment in pediatric epilepsies[J]. Rev Neurol, 2016, 172(3): 182-185. doi: 10.1016/j.neurol.2015.12.009
[14]	KONG Z W, SUN S Y, SHI Q D, et al. Short-term ketogenic diet improves abdominal obesity in overweight/obese Chinese young females[J]. Front Physiol, 2020, 11: 856. doi: 10.3389/fphys.2020.00856
[15]	MICHALCZYK M M, KLONEK G, MASZCZYK A, et al. The effects of a low calorie ketogenic diet on glycaemic control variables in hyperinsulinemic overweight/obese females[J]. Nutrients, 2020, 12(6): 1854. doi: 10.3390/nu12061854
[16]	MORENO B, CRUJEIRAS A B, BELLIDO D, et al. Obesity treatment by very low-calorie-ketogenic diet at two years: reduction in visceral fat and on the burden of disease[J]. Endocrine, 2016, 54(3): 681-690. doi: 10.1007/s12020-016-1050-2
[17]	YANG H J, SHAN W, ZHU F, et al. Ketone bodies in neurological diseases: focus on neuroprotection and underlying mechanisms[J]. Front Neurol, 2019, 10: 585. doi: 10.3389/fneur.2019.00585
[18]	PINTO A, BONUCCI A, MAGGI E, et al. Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer's disease[J]. Antioxidants, 2018, 7(5): 63. doi: 10.3390/antiox7050063
[19]	KONG G G, HUANG Z C, JI W, et al. The ketone metabolite β-hydroxybutyrate attenuates oxidative stress in spinal cord injury by suppression of class I histone deacetylases[J]. J Neurotrauma, 2017, 34(18): 2645-2655. doi: 10.1089/neu.2017.5192
[20]	LONGO R, PERI C, CRICRÌ D, et al. Ketogenic diet: a new light shining on old but gold biochemistry[J]. Nutrients, 2019, 11(10): 2497. doi: 10.3390/nu11102497
[21]	DAL BELLO S, VALDEMARIN F, MARTINUZZI D, et al. Ketogenic diet in the treatment of gliomas and glioblastomas[J]. Nutrients, 2022, 14(18): 3851. doi: 10.3390/nu14183851
[22]	PANHANS C M, GRESHAM G, AMARAL L J, et al. Exploring the feasibility and effects of a ketogenic diet in patients with CNS malignancies: a retrospective case series[J]. Front Neurosci, 2020, 14: 390. doi: 10.3389/fnins.2020.00390
[23]	MONTELLA L, SARNO F, ALTUCCI L, et al. A root in Synapsis and the other one in the gut microbiome-brain axis: are the two poles of ketogenic diet enough to challenge glioblastoma[J]. Front Nutr, 2021, 8: 703392. doi: 10.3389/fnut.2021.703392
[24]	OLSON C A, VUONG H E, YANO J M, et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet[J]. Cell, 2018, 174(2): 497. doi: 10.1016/j.cell.2018.06.051
[25]	ZHANG Y J, ZHOU S Z, ZHOU Y F, et al. Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet[J]. Epilepsy Res, 2018, 145: 163-168. doi: 10.1016/j.eplepsyres.2018.06.015
[26]	GONG X, CAI Q Y, LIU X, et al. Gut flora and metabolism are altered in epilepsy and partially restored after ketogenic diets[J]. Microb Pathog, 2021, 155: 104899. doi: 10.1016/j.micpath.2021.104899
[27]	NAGPAL R, NETH B J, WANG S H, et al. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment[J]. EBioMedicine, 2019, 47: 529-542. doi: 10.1016/j.ebiom.2019.08.032
[28]	张汀樾, 李钰婷, 李小舟, 等. 生酮饮食与代谢相关脂肪性肝病的关系[J]. 实用临床医药杂志, 2021, 25(18): 1-5. doi: 10.7619/jcmp.20212327
[29]	李瑞暖, 谢苗莹, 曾榕, 等. 基于文献计量视角分析癫痫与生酮饮食的相关性研究[J]. 实用临床医药杂志, 2023, 27(8): 40-47. doi: 10.7619/jcmp.20223635
[30]	LOPASCHUK G D, KARWI Q G, HO K L, et al. Ketone metabolism in the failing heart[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2020, 1865(12): 158813.
[31]	KARWI Q G, BISWAS D, PULINILKUNNIL T, et al. Myocardial ketones metabolism in heart failure[J]. J Card Fail, 2020, 26(11): 998-1005. doi: 10.1016/j.cardfail.2020.04.005
[32]	BYRNE N J, SONI S, TAKAHARA S, et al. Chronically elevating circulating ketones can reduce cardiac inflammation and blunt the development of heart failure[J]. Circ Heart Fail, 2020, 13(6): e006573. doi: 10.1161/CIRCHEARTFAILURE.119.006573

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Research hotspots and trends in ketogenic diet from 2013 to 2022 based on the Web of Science database