Correlations of plasma Alarin level with glucose and lipid metabolism and chronic inflammation in newly diagnosed type 2 diabetic patients with obesity

  Objective  To explore the correlations of plasma Alarin level and lipid metabolism, chronic inflammation in newly diagnosed type 2 diabetes patients with obesity.

  Methods  A total of 300 patients with diabetes were selected as study subjects. According to the obesity situation, they were divided into T2DM obese group (n=128) and T2DM non-obese group (n=172). Another 100 healthy population who underwent physical examinations during the same period were selected as control group. Plasma Alarin levels were detected by enzyme linked immunosorbent assay (ELISA). Fasting insulin (FINS), 2 h postprandial insulin (2 hINS), insulin resistance index (HOMA-IR) and serum glycosylated hemoglobin (HbAlc), fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), serum interleukin 6 (IL-6) and C-reaction protein (CRP) and tumor necrosis factor-α(TNF-α) of different groups were compared.

  Results  The plasma Alarin level of the T2DM obese group was significantly higher than that in the T2DM non-obese group and control group (P < 0.05), and was higher in the T2DM non-obese group than that in the control group (P < 0.05). The levels of FINS, 2 hINS and HOMA-IR in the T2DM obese group were significantly higher than those in the non-obese group and the control group, and were significantly higher in the T2DM non-obese group than those in the control group (P < 0.05). The levels of HbAlc, FPG, TC, TG and LDL-C in the T2DM obese group were significantly higher than those of the T2DM non-obese group and the control group, HDL-C level was significantly lower than that of the T2DM non-obese group and the control group (P < 0.05). The levels of HbAlc, FPG, TC, TG and LDL-C in the T2DM non-obese group were significantly higher than those of the control group, HDL-C level was significantly lower than the control group (P < 0.05). The levels of CRP, IL-6 and TNF-α in the T2DM obesity group were significantly higher than those in T2DM non-obesity group and control group, and were significantly higher in the T2DM non-obesity group than those in the control group (P < 0.05). Pearson correlation analysis showed that plasma Alarin was positively correlated with FINS, 2 hINS, HOMA-IR, HbAlc, FPG, TC, TG, LDL-C, CRP, IL-6 and TNF-α levels in T2DM patients (P < 0.05), and negatively correlated with HDL-C levels (P < 0.05).

  Conclusion  The plasma Alarin level in newly diagnosed type 2 diabetic patients is significantly increased, which is closely related to obesity, glucose and lipid metabolism disorder, insulin resistance and chronic inflammatory response. Plasma Alarin level is increased with the increase of risk factors of metabolic abnormalities.