Citation: | LU Yuanjun, LUAN Mei, FU Min, PAN Yumin, LIU Yanxi, SONG Jinling, ZENG Jiantao. Thyroid hormone levels in patients with acute ischemic stroke and non-valvular atrial fibrillation[J]. Journal of Clinical Medicine in Practice, 2024, 28(8): 75-78. DOI: 10.7619/jcmp.20233711 |
To analyze the thyroid hormone levels in patients with acute ischemic stroke (AIS) and non-valvular atrial fibrillation (NVAF).
A total of 121 patients with AIS were selected, and were divided into NVAF group (AIS patients with NVAF) and control group (AIS patients without atrial fibrillation). Serum levels of triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in two groups were measured and compared. The survival of the two groups was compared.
The serum T3 level in the NVAF group was significantly lower than that in the control group (P < 0.05). There were no significant differences in serum FT3, T4, FT4 and TSH levels between the two groups (P>0.05). There was no significant difference in survival between the two groups (P>0.05).
NVAF is associated with serum T3 levels in AIS patients. There is no correlation between the risk of death and NVAF in AIS patients.
[1] |
MA Q F, LI R, WANG L J, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019[J]. Lancet Public Health, 2021, 6(12): e897-e906. doi: 10.1016/S2468-2667(21)00228-0
|
[2] |
FROST L, ANDERSEN L V, JOHNSEN S P, et al. Lost life years attributable to stroke among patients with nonvalvular atrial fibrillation: a nationwide population-based follow-up study[J]. Neuroepidemiology, 2007, 29 (1/2): 59-65.
|
[3] |
中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004
|
[4] |
鲁远君, 付照平, 栾梅, 等. 急性缺血性脑卒中患者甲状腺激素与疾病严重程度及死亡的关系[J]. 临床内科杂志, 2022, 39(6): 400-402. doi: 10.3969/j.issn.1001-9057.2022.06.012
|
[5] |
FRANCESCHI C, OSTAN R, MARIOTTI S, et al. The aging thyroid: a reappraisal within the geroscience integrated perspective[J]. Endocr Rev, 2019, 40(5): 1250-1270.
|
[6] |
DUNTAS L H. Aging and the hypothalamic-pituitary-thyroid axis[J]. Vitam Horm, 2021, 115: 1-14.
|
[7] |
CHEN J Y, LIPPO L, LABELLA R, et al. Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system[J]. EMBO J, 2021, 40(1): e105242. doi: 10.15252/embj.2020105242
|
[8] |
O'KEEFE L M, CONWAY S E, CZAP A, et al. Thyroid hormones and functional outcomes after ischemic stroke[J]. Thyroid Res, 2015, 8: 9. doi: 10.1186/s13044-015-0021-7
|
[9] |
DAVIS P J, GLINSKY G V, LIN H Y, et al. Actions of thyroid hormone analogues on chemokines[J]. J Immunol Res, 2016, 2016: 3147671.
|
[10] |
卓蕊, 李结华. 高龄非瓣膜性心房颤动患者的抗凝治疗探讨[J]. 实用临床医药杂志, 2020, 24(12): 42-44. doi: 10.7619/jcmp.202012012
|
[11] |
BOURSIER-BOSSY V, ZUBER M, EMMERICH J. Ischemic stroke and non-valvular atrial fibrillation: when to introduce anticoagulant therapy[J]. J Med Vasc, 2020, 45(2): 72-80.
|
[12] |
WANKOWICZ P, NOWACKI P, GOŁAB-JANOWSKA M. Risk factors for ischemic stroke in patients with non-valvular atrial fibrillation and therapeutic international normalized ratio range[J]. Arch Med Sci, 2019, 15(5): 1217-1222. doi: 10.5114/aoms.2018.77546
|
[13] |
WANG L L, ZHANG Y. Role of hyperhomocysteine, thyroid dysfunction and their interaction in ischemic stroke patients with non-valvular atrial fibrillation[J]. Sci Rep, 2020, 10(1): 12419. doi: 10.1038/s41598-020-69449-2
|
[14] |
BUNEVICIUS A, IERVASI G, BUNEVICIUS R. Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders[J]. Expert Rev Neurother, 2015, 15(3): 315-326. doi: 10.1586/14737175.2015.1013465
|
[15] |
LIU J F, WANG D R, XIONG Y, et al. Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients[J]. Neurol Res, 2016, 38(5): 429-433. doi: 10.1080/01616412.2016.1178480
|
[16] |
BASHYAL S, GORKHALY M P, DEVKOTA R, et al. Alteration of Thyroid Hormone among Patients with Ischemic Stroke visiting a Tertiary Care Hospital: a Descriptive Cross-sectional Study[J]. JNMA J Nepal Med Assoc, 2021, 59(240): 779-782. doi: 10.31729/jnma.6501
|
[17] |
SIDOROV E, PAUL A, XU C, et al. Decrease of thyroid function after ischemic stroke is related to stroke severity[J]. Thyroid Res, 2023, 16(1): 28. doi: 10.1186/s13044-023-00160-w
|
[18] |
SUDA S, SHIMOYAMA T, NAGAI K, et al. Low free triiodothyronine predicts 3-month poor outcome after acute stroke[J]. J Stroke Cerebrovasc Dis, 2018, 27(10): 2804-2809. doi: 10.1016/j.jstrokecerebrovasdis.2018.06.009
|
[19] |
THYGESEN S K, FROST L, EAGLE K A, et al. Atrial fibrillation in patients with ischemic stroke: a population-based study[J]. Clin Epidemiol, 2009, 1: 55-65.
|
[20] |
FERNANDES L, SARGENTO-FREITAS J, MILNER J, et al. Ischemic stroke in patients previously anticoagulated for non-valvular atrial fibrillation: why does it happen[J]. Rev Port Cardiol, 2019, 38(2): 117-124. doi: 10.1016/j.repc.2018.06.004
|
[21] |
CHAN Y H, LEE H F, CHAO T F, et al. Real-world comparisons of direct oral anticoagulants for stroke prevention in Asian patients with non-valvular atrial fibrillation: a systematic review and meta-analysis[J]. Cardiovasc Drugs Ther, 2019, 33(6): 701-710. doi: 10.1007/s10557-019-06910-z
|
[22] |
PAPALEONTIOU M, LEVINE D A, REYES-GASTELUM D, et al. Thyroid hormone therapy and incident stroke[J]. J Clin Endocrinol Metab, 2021, 106(10): e3890-e3900. doi: 10.1210/clinem/dgab444
|
[23] |
MUROLO M, VINCENZO O D, CICATIELLO A G, et al. Cardiovascular and neuronal consequences of thyroid hormones alterations in the ischemic stroke[J]. Metabolites, 2022, 13(1): 22. doi: 10.3390/metabo13010022
|
[24] |
TALHADA D, SANTOS C R A, GONÇALVES I, et al. Thyroid hormones in the brain and their impact in recovery mechanisms after stroke[J]. Front Neurol, 2019, 10: 1103.
|
1. |
喻洁明,任荣飞,陈晓亮. 耳内镜下应用耳屏软骨-软骨膜复合体行Ⅰ型鼓室成形术的临床疗效研究. 中国医学文摘(耳鼻咽喉科学). 2024(01): 130-132+108 .
![]() | |
2. |
包勇正,邹文兰,胡志邦,马敬. 29例鼓膜大穿孔患者耳内镜下鼓膜成形术疗效观察. 实用临床医药杂志. 2020(23): 42-44 .
![]() |