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LIU Zhen, PAN Guangdong, LIU Qiang, YUAN Lin, XIAO Yi. Influnece of hepatitis B virus X protein on Period 1 expression and methylation level of CCL13 cells[J]. Journal of Clinical Medicine in Practice, 2014, (16): 56-59. DOI: 10.7619/jcmp.201416016
Citation: LIU Zhen, PAN Guangdong, LIU Qiang, YUAN Lin, XIAO Yi. Influnece of hepatitis B virus X protein on Period 1 expression and methylation level of CCL13 cells[J]. Journal of Clinical Medicine in Practice, 2014, (16): 56-59. DOI: 10.7619/jcmp.201416016
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Influnece of hepatitis B virus X protein on Period 1 expression and methylation level of CCL13 cells

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  • Published Date: September 10, 2014
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  • Objective To explore the relationship between hepatitis B virus (HBV)X pro-tein and inhibited expression of CCL13 cells Period 1.Methods The pcDNA3.1-HBx plasmid was transfected into CCL13 cells by Lipofectamine in vitro.Period1 expression and its promoter methylation level in CCL13 and CCL13-HBx were detected by treatments of reverse transcription PCR,western blot and methylation-specific PCR.Results The human liver cell lines CCL13-HBx contained stable HBx gene expression.Compared to CCL13,methylation level of period1 promoter increased in CCL13-HBx,and expression level of its mRNA and protein decreased.Conclusion Hepatitis B virus X pro-tein can decrease period1 expression in CCL13 by up-regulating its promoter methylation level.
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