Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury

  Objective  To analyze the levels of serum total bile acid (TBA), cholyglycine (CG) of pregnant women with intrahepatic cholestasis of pregnancy (ICP) and conditions of neonatal lung injury.

  Methods  A total of 60 ICP puerperas were selected as observation group, and 60 healthy puerperas during the same period were selected as control group. Serum TBA, CG levels were compared, and neonatal pulmonary artery blood flow index as well as lung injury of the two groups were compared.

  Results  The serum levels of TBA and CG in the observation group were significantly higher than those in the control group (P < 0.01). The incidence of neonatal lung injury, pulmonary artery blood flow index in the observation group were significantly higher than that in the control group (P < 0.05). The serum TBA levels of puerperas with delivered neonates complicating neonatal pneumonia, respiratory distress and asphyxia in the observation group were (22.67±4.57), (32.23±7.78), (65.83±14.57) μmol/L, respectively, which showed positive correlations with the degree of neonatal lung injury (r=0.653, P < 0.01).

  Conclusion  The serum TBA and CG levels of pregnant ICP women are significantly higher than those of normal healthy women, and their higher levels are correlated with the occurrence of neonatal lung injury.