Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury

TIAN Xiaofei; MA Huan

doi:10.7619/jcmp.201922029

Journal of Clinical Medicine in Practice > 2019 > 23(22): 85-87. > DOI: 10.7619/jcmp.201922029

TIAN Xiaofei, MA Huan. Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury[J]. Journal of Clinical Medicine in Practice, 2019, 23(22): 85-87. DOI: 10.7619/jcmp.201922029

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Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury

TIAN Xiaofei¹,
MA Huan^2, ,

1.
Department of Pediatrics, The First Hospital of Yulin in Shaanxi Province, Yulin, Shaanxi, 719000
2.
Department of Obstetrics and Gynecology, The First Hospital of Yulin in Shaanxi Province, Yulin, Shaanxi, 719000

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Received Date: September 09, 2019
Accepted Date: October 24, 2019
Available Online: February 28, 2021
Published Date: November 27, 2019

Graphical Abstract

Abstract

Abstract

Objective To analyze the levels of serum total bile acid (TBA), cholyglycine (CG) of pregnant women with intrahepatic cholestasis of pregnancy (ICP) and conditions of neonatal lung injury.
Methods A total of 60 ICP puerperas were selected as observation group, and 60 healthy puerperas during the same period were selected as control group. Serum TBA, CG levels were compared, and neonatal pulmonary artery blood flow index as well as lung injury of the two groups were compared.
Results The serum levels of TBA and CG in the observation group were significantly higher than those in the control group (P < 0.01). The incidence of neonatal lung injury, pulmonary artery blood flow index in the observation group were significantly higher than that in the control group (P < 0.05). The serum TBA levels of puerperas with delivered neonates complicating neonatal pneumonia, respiratory distress and asphyxia in the observation group were (22.67±4.57), (32.23±7.78), (65.83±14.57) μmol/L, respectively, which showed positive correlations with the degree of neonatal lung injury (r=0.653, P < 0.01).
Conclusion The serum TBA and CG levels of pregnant ICP women are significantly higher than those of normal healthy women, and their higher levels are correlated with the occurrence of neonatal lung injury.
- pregnancy cholestasis,
- pregnant women,
- total bile acid,
- glycocholic acid,
- neonatal lung injury

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Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury

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