Advance Search
LU Cuiyan, PAN Weifeng, SHAO Yu, CAO Wen. Effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke and its influence on cerebral blood flow[J]. Journal of Clinical Medicine in Practice, 2020, 24(3): 40-43. DOI: 10.7619/jcmp.202003012
Citation: LU Cuiyan, PAN Weifeng, SHAO Yu, CAO Wen. Effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke and its influence on cerebral blood flow[J]. Journal of Clinical Medicine in Practice, 2020, 24(3): 40-43. DOI: 10.7619/jcmp.202003012
shu

Effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke and its influence on cerebral blood flow

  • 1. Department of Pharmacy, Putuo District Hospital of Traditional Chinese Medicine, Shanghai, 200062;

  • 2. Pharmacy Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200437

More Information
  • Received Date: November 15, 2019
    Graphical Abstract
    • Abstract
  • Objective To explore curative effect of Naoxuekang Capsule combined with anti-platelet therapy on ischemic stroke(IS)and its influence on cerebral blood flow(CBF). Methods A total of 533 IS patients who were admitted to the hospital were enrolled as study objects. According to different treatment plans, they were divided into three groups. A total of 217 patients treated with aspirin were included in aspirin group, 184 patients treated with Naoxuekang Capsules were included in Naoxuekang group, and 132 patients treated with aspirin and Naoxuekang Capsules were included in combination group. The clinical curative effect, score of National Institutes of Health Stroke Scale(NIHSS), platelet aggregation rate, cerebral blood flow velocity and cerebral blood flow volume were compared among the three groups. Results The total response rate of treatment in combination group was 91.67%, which was significantly higher than 82.95% in aspirin group and 80.98% in Naoxuekang group(P < 0.05). After 1-, 2- and 3- month treatment, NIHSS score and platelet aggregation rate in combination group were lower than those in aspirin group and Naoxuekang group(P < 0.05). The cerebral blood flow velocity and cerebral blood flow volume in combination group were higher than those in aspirin group and Naoxuekang group(P < 0.05). There were no significant differences in total response rate of treatment, NIHSS score, platelet aggregation rate, cerebral blood flow velocity or - cerebral blood flow volume between aspirin group and Naoxuekang group(P > 0.05). Conclusion The antithrombotic effect of Naoxuekang Capsule is similar to that of aspirin. The combined application of Naoxuekang Capsule and aspirin in IS patients can improve nerve function, increase cerebral blood flow volume, and improve curative effect.
    • FullText(HTML)
    • References (20)
  • Randolph S A. Ischemic stroke[J]. Workplace Health Saf, 2016,64(9): 444-448.
    Radu R A, Terecoasă E O, Băjenaru O A, et al. Etiologic classification of ischemic stroke: Where do we stand[J]. Clin Neurol Neurosurg, 2017, 8(159): 93-106.
    Radak D, Katsiki N, Resanovic I, et al. Apoptosis and acute brain ischemia in ischemic stroke[J]. Curr Vasc Pharmacol, 2017, 15(2): 115-122.
    Feng R, Badgeley M, Mocco J, et al. Deep learning guided stroke management: a review of clinical applications[J]. J Neurointerv Surg, 2018, 10(4): 358-362.
    Rabinstein A A. Treatment of Acute Ischemic Stroke[J]. Continuum, 2017, 23(1): 62-81.
    毛全高. 水蛭素剂型研究进展[J]. 安徽医药, 2015, 19(12): 2250-2254.
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2014[J]. 中华神经科杂志, 2015, 48(4): 246-257.
    李霞, 王炜, 赵仕琪, 等. 脑梗死患者COX-1及COX-2基因多态性与阿司匹林抵抗的相关性分析[J]. 中风与神经疾病杂志, 2019, 36(6): 488-492.
    Hao Q, Tampi M, O'Donnell M, et al. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis[J]. BMJ, 2018, 18(363): 5108.
    刘玉府, 王利红.人尿激肽原酶联合血小板抑制剂对高血压脑梗死大鼠凝血功能及神经功能的影响[J]. 中华实验外科杂志, 2016, 33(6): 1597-1600.
    赵华, 龚道恺. 阿司匹林片联合阿托伐他汀钙片治疗急性脑梗死的临床研究[J]. 中国临床药理学杂志, 2016, 32(21): 1934-1936.
    林子霖. 基于近15年文献分析探讨急性脑梗死的中医证治[D]. 广州: 广州中医药大学, 2014.
    韦维, 李国辉, 陈绚, 等. 注射用血栓通联合依达拉奉治疗缺血性脑卒中的临床疗效及对患者神经功能缺损和生活质量的影响[J]. 实用临床医药杂志, 2017, 21(7): 140-142.
    Müller C, Haase M, Lemke S. 9884 Hemorrhagic Stroke Associated with High aPTTs Following Thrombolytic Therapy and Heparin or Hirudin[J]. Parasitol Res, 2017, 116(1): 313-325.
    Nowak G, Schrör K. Hirudin-the long and stony way from an anticoagulant peptide in the saliva of medicinal leech to a recombinant drug and beyond[J]. A historical piece, 2017, 98(1): 116-119.
    Zhang J, Lan N. Hirudin variants production by genetic engineered microbial factory[J]. Biotechnol Genet Eng Rev, 2018, 34(2): 261-280.
    Liu Y, Yang J, Wang J, et al. Test of hirudin activity by tracking the binding of hirudin to thrombin in the presence of BS3 cross-linking[J]. Blood Coagul Fibrinolysis, 2015, 26(7): 823-826.
    Sheffield W P, Eltringham L J, Bhakta V. A factor XIa-activatable hirudin-albumin fusion protein reduces thrombosis in mice without promoting blood loss[J]. BMC Biotechnol, 2018,18(1): 21-26.
    李红, 吴黎黎, 高青, 等. 水蛭素对脑出血大鼠蛋白酪氨酸激酶2/信号转导和转录激活因子3信号通路的影响[J]. 中国脑血管病杂志, 2017, 14(12): 638-643.
    张锐, 宋郁喜, 黄荣等. 灯盏花素联合依达拉奉治疗缺血性脑卒中的临床疗效及对患者神经功能缺损和生活质量的影响[J]. 实用临床医药杂志, 2017, 21(3): 15-18.
    • Related Articles

  • Related Articles

    [1]ZHANG Jinling, LI Yongle. Predictive value of transvaginal ultrasound blood flow parameters combined with serum anti-mullerian hormone for in vitro fertilization embryo transfer pregnancy failure in polycystic ovary syndrome infertility[J]. Journal of Clinical Medicine in Practice, 2024, 28(4): 125-130, 135. DOI: 10.7619/jcmp.20233003
    [2]LIU Weili, WU Xufeng, ZHENG Qingbin, MENG Lijun, FENG Yaping, JIANG Xuechuan, LI Yucheng, YUAN Wenjie. Study on stability of carotid blood flow measurement based on blood flow vector[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 29-34. DOI: 10.7619/jcmp.20222785
    [3]CHEN Xinxing, ZHANG Li. Effect of butylphthalide soft capsule on cerebral blood perfusion and cognitive function in patients with mild cognitive impairment after cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2020, 24(21): 50-53. DOI: 10.7619/jcmp.202021015
    [4]ZHOU Jinming, YU He, GUAN Shengyi. Clinical effect of Flow-through venous skin flap in the repair of replantation of amputation with circular defect[J]. Journal of Clinical Medicine in Practice, 2020, 24(13): 23-25. DOI: 10.7619/jcmp.202013007
    [5]CHEN Fei, WANG Yixiong, ZHOU Ying, HUANG Xianmei, QIAN Qin. Relationship between Doppler ultrasound examination of blood flow of uterine arteries in the second trimester and the outcomes of preeclampsia,prognosis of neonates[J]. Journal of Clinical Medicine in Practice, 2018, (9): 75-78. DOI: 10.7619/jcmp.201809020
    [6]QI Xuezhang, MEI Bingyin, XU Junfeng, WANG Na, SHU Zhigang. Investigation on cerebral microbleeds condition of 161 patients with cerebral hemorrhage[J]. Journal of Clinical Medicine in Practice, 2017, (7): 16-20. DOI: 10.7619/jcmp.201707005
    [7]LUO Xiaojing, BAI Liang, YANG Chengrong. Effect of edaravone injection combined with salvianolate on cerebral hemodynamics of patients with cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2017, (1): 19-21,44. DOI: 10.7619/jcmp.201701005
    [8]ZHAO Hong, HUO Xiaohui, PEI Huaiteng. Influence of hyperbaric oxygenation on oxidative stress state and cerebral blood flow of newborns with neonatal hypoxie-ischemic encephalopathy[J]. Journal of Clinical Medicine in Practice, 2016, (17): 85-87. DOI: 10.7619/jcmp.201617026
    [9]ZHANG Junmai. Impact of pulmonary surfactant combined with budesonide on cerebral blood flow of acute cerebral injury patients with respiratory distress syndrome[J]. Journal of Clinical Medicine in Practice, 2015, (5): 15-17,21. DOI: 10.7619/jcmp.201505005
    [10]EXPERIMENTAL INTRACEREBRAL HEMORRHAGE:EFFECT ON REGIONAL CEREBRAL BLOOD FLOW[J]. Journal of Clinical Medicine in Practice, 1997, (4): 238-240.

  • Cited by

    Periodical cited type(7)

    1. 王雪清，唐景丽，李彬. 急诊采用胰岛素一次性冲击治疗糖尿病酮症酸中毒的临床研究. 系统医学. 2024(04): 121-124 .
    2. 陈良泉，卢少辉，高裕容，林海渊. 血清淀粉酶、肌酸激酶与炎症因子对2型糖尿病酮症酸中毒继发感染的诊断价值. 中国卫生标准管理. 2024(08): 96-99 .
    3. 张兆庆. HbA1c、CK、FBG对糖尿病微血管病变的筛查效果分析. 婚育与健康. 2024(08): 196-198 .
    4. 张建丽，李丽花，朱丽丽. AMS、BUN及β-HB在糖尿病酮症酸中毒诊断及病情评估中的作用. 分子诊断与治疗杂志. 2023(11): 2008-2011+2015 .
    5. 何佳儿，张才英，马强，周筱，孙亚萍. 人分泌型磷脂酶A2-X、β-防御素3、C-反应蛋白与pH比值在老年糖尿病酮症酸中毒伴感染患者病情评估中的价值. 中国卫生检验杂志. 2022(18): 2252-2256 .
    6. 麦高阳，李鲁强，杜欣媚，李有佳. 绝经后2型糖尿病患者血清微量元素和电解质与空腹血糖和糖化血红蛋白的相关性分析. 慢性病学杂志. 2021(10): 1481-1484 .
    7. 韩慧萍，卢海龙. PCT/HCO_3~-、CK、HBP与老年糖尿病酮症酸中毒伴感染患者预后的关系及联合预测预后效能分析. 解放军医药杂志. 2021(11): 76-80 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views (272) PDF downloads (12) Cited by(9)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return