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LEI Zhenmin, WANG Xi. Influencing factors of upper gastrointestinal bleeding in coronary heart disease patients treated with double antiplatelet therapy[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 112-114. DOI: 10.7619/jcmp.202014031
Citation: LEI Zhenmin, WANG Xi. Influencing factors of upper gastrointestinal bleeding in coronary heart disease patients treated with double antiplatelet therapy[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 112-114. DOI: 10.7619/jcmp.202014031
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Influencing factors of upper gastrointestinal bleeding in coronary heart disease patients treated with double antiplatelet therapy

  • Department of Internal Medicine, Shaanxi Provincial Rehabilitation Hospital, Xi'an, Shaanxi, 710065

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  • Received Date: June 28, 2020
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  • Objective To investigate the incidence of upper gastrointestinal bleeding in coronary heart disease patients treated with dual antiplatelet therapy, and to analyze its influencing factors. Methods A retrospective analysis was performed to review the clinical materials of 100 patients with coronary heart disease, and were divided into control group and study group according to different medication regimens. The control group was treated with aspirin, and the study group was additionally treated with clopidogrel bisulfate based on the control group. The incidence of upper gastrointestinal bleeding, coagulation indexes［prothrombin time(PT), and activated partial thromboplastin time(APTT)］before and after treatment, and platelet aggregation rate were compared, and the influencing factors of digestive bleeding were analyzed. Results The incidence of upper gastrointestinal hemorrhage in the study group was 34.29%, which was higher than 12.31% in the control group, and the difference was significant(P<0.05); there were no significant differences between the two groups before treatment in PT, APTT and platelet aggregation rate(P>0.05); after treatment, the levels of PT and APTT in the study group were significantly higher than that in the control group, and the platelet aggregation rate was significantly lower than that in the control group(P<0.05). Seventy years of age and above, history of gastrointestinal disease, chronic renal insufficiency, more than 3 months of medication time, history of diabetes and alcoholism were important influencing factors for upper gastrointestinal bleeding(P<0.05). Conclusion The risk of upper gastrointestinal bleeding caused by double antiplatelet therapy in patients with coronary heart disease is high. Therefore, it is necessary to strengthen prevention and control measures during clinical medication to reduce the risk - of bleeding and ensure the safety of medication.
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  • 杨露, 谭梦彤, 徐璐, 等. 同型半胱氨酸水平对急性冠脉综合征患者预后及出血风险的影响[J]. 中国循证心血管医学杂志, 2020, 12(1): 31-34

    , 38.
    杨延洁, 周慧龙. 不同双抗血小板疗程对冠心病合并房颤PCI术后患者远期预后的影响[J]. 陕西医学杂志, 2019, 48(12): 1653-1656.
    刘宏丽, 尹立勇, 尹小波, 等. 急性脑梗死患者发生抗血小板药物抵抗的相关因素研究[J]. 中国煤炭工业医学杂志, 2019, 22(4): 366-371.
    孙沙沙, 陈薇, 胡家宾, 等. 新型口服抗凝药在冠心病患者中的研究进展[J]. 中华老年心脑血管病杂志, 2019, 21(6): 664-665.
    耿二冬, 宁涓. 冠心病双联抗血小板治疗中消化道出血的相关危险因素分析[J]. 中国基层医药, 2019(11): 1321-1324.
    孙晓倩. 西洛他唑与阿司匹林分别联合氯吡格雷对冠心病患者血小板聚集率的影响研究[D]. 南充: 川北医学院, 2019.
    卢丽华, 潘朝庆, 李学林, 等. 双联抗血小板治疗对冠心病患者凝血纤溶指标及血小板功能的影响[J]. 血栓与止血学, 2018, 24(2): 263-265.
    李开亮, 张帷, 王海军, 等. 年龄>75岁老年冠心病患者应用不同抗血小板药物临床疗效观察[J]. 中华高血压杂志, 2018, 26(4): 400-400.
    张宁, 王喆. 冠心病PCI患者服用双联抗血小板药物后氯吡格雷抵抗发生情况及影响因素分析[J]. 白求恩医学杂志, 2017, 15(6): 764-765.
    苗林子, 陆遥, 屈晨雪, 等. 冠心病患者经皮冠状动脉介入治疗术后抗血小板药物治疗监测及平均血小板体积变化[J]. 临床检验杂志, 2017, 35(6): 439-443.
    吕佳杰, 王真, 李娥. 三七总皂苷配合双联抗血小板药物对人脐静脉内皮细胞损伤和内皮血小板黏附的影响[J]. 中药药理与临床, 2017, 33(1): 99-102.
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