ZHANG Jianlei, LUO Xingjing. Effect of cerebral oxygen saturation monitoring in children with laparoscopic surgery in protection of brain in high altitude area[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 58-62. DOI: 10.7619/jcmp.20210312
Citation: ZHANG Jianlei, LUO Xingjing. Effect of cerebral oxygen saturation monitoring in children with laparoscopic surgery in protection of brain in high altitude area[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 58-62. DOI: 10.7619/jcmp.20210312

Effect of cerebral oxygen saturation monitoring in children with laparoscopic surgery in protection of brain in high altitude area

More Information
  • Received Date: January 14, 2021
  • Available Online: June 14, 2021
  • Published Date: June 14, 2021
  •   Objective  To investigate the effect of cerebral oxygen saturation (rSO2) on postoperative cognitive dysfunction (POCD) and S-100β protein in children after laparoscopic surgery at high altitude.
      Methods  A total of 68 children who underwent elective laparoscopic surgery at Shigatse People's Hospital (3850 m above sea level) were selected as research subjects. They were divided into study group (n=34) and control group (n=34). Children in both groups underwent general anesthesia before the operation, the control group underwent total intravenous anesthesia, the study group underwent tracheal intubation anesthesia. Near-infrared spectroscopy was used to continuously monitor level of rSO2. The levels of rSO2 of the two groups were recorded at the time points of entering the room (T0), after mask oxygen inhalation (T1), before establishment of pneumoperitoneum (T2), and after 30 minutes of pneumoperitoneum (T3), and the end of pneumoperitoneum (T4). The cognitive function changes before operation, 1 day and 3 days after operation were evaluated and recorded by Mini-mental State Examination (MMSE), the changes of S-100 β protein levels before operation, 1 day after operation and 3 days after operation and the incidence of POCD were compared between the two groups.
      Results  The levels of rSO2 of the two groups were higher at T4 than those of the T0, T1, T2 and T3 (P < 0.05), were higher at T3 in both groups than those at T0, T1 and T2 (P < 0.05), and were higher at T2 in both groups than those of T0 (P < 0.05). The MMSE scores of the two groups at 1, 3 d were lower than those before operation (P < 0.05). The scores of MMSE after 3, 7 d of operation were higher than that of 1 day of operation, and the scores of MMSE at 7 d in both groups were higher than those at 3 d (P < 0.05). There was no significant difference between 7 d MMSE score and preoperative MMSE score in the two groups (P>0.05). The S-100 β protein levels in the two groups at different time points of 1 and 3 d were significantly higher than preoperation, were lower at 3, 7 d than at 1 d after operation (P < 0.05). There was no significant difference in S-100β protein level between 7 days after operation and preoperation(P>0.05). The incidence of POCD was 8.82% in the study group and 5.88% in the control group, there was no significant difference in the incidence of POCD between the two groups (P>0.05).
      Conclusion  Monitoring and regulating rSO2 during laparoscopic operation in children in highland area can reduce the occurrence of POCD, and effectively reduce the serum S-100β protein level 3 days after operation. Regardless of applition of intravenous anesthesia or endotracheal intubation anesthesia, it has a brain protective effect.
  • [1]
    朱世春, 刘振勇, 戴家瑗. 小儿腹腔镜和传统睾丸下降固定术的疗效比较[J]. 实用临床医药杂志, 2018, 22(7): 102-103. doi: 10.7619/jcmp.201807028
    [2]
    杨波, 姜丽华, 王涛, 等. 腹腔镜宫颈癌根治术中手控和压控肺复张的应用效果[J]. 郑州大学学报: 医学版, 2020, 55(3): 410-414. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYK202003027.htm
    [3]
    吉文玉. 新疆儿童先天性脑积水手术前后认知功能障碍的临床研究[D]. 乌鲁木齐: 新疆医科大学, 2016.
    [4]
    MICHETTI F, D'AMBROSI N, TOESCA A, et al. The S100B story: from biomarker to active factor in neural injury[J]. J Neurochem, 2019, 148(2): 168-187. doi: 10.1111/jnc.14574
    [5]
    刘文俊, 陈应富, 唐杨, 等. 先天性心脏病术后脑组织氧饱和度与其预后的相关性分析[J]. 重庆医科大学学报, 2018, 43(11): 1508-1512. https://www.cnki.com.cn/Article/CJFDTOTAL-ZQYK201811020.htm
    [6]
    李明霞, 马健, 陆国平. 近红外光谱技术对脓毒症儿童脑血氧水平监测的价值[J]. 中国小儿急救医学, 2018, 25(8): 585-589, 596. doi: 10.3760/cma.j.issn.1673-4912.2018.08.008
    [7]
    郭梁. 简易智能量表联合多导视频脑电图评估儿童缺氧性脑损伤认知功能的价值[J]. 实用临床医学, 2016, 17(6): 65-66, 69. https://www.cnki.com.cn/Article/CJFDTOTAL-LCSY201606024.htm
    [8]
    周恩惠. 腹腔镜离断式肾盂输尿管成形术治疗UPJO肾积水患儿围术期指标术后并发症及预后的影响[J]. 河北医学, 2020, 26(10): 1663-1667. doi: 10.3969/j.issn.1006-6233.2020.10.019
    [9]
    和崇军, 和桥顺, 张四红. 高原地区儿童重型颅脑损伤的特点及疗效[J]. 中华神经外科杂志, 2017, 33(10): 1050-1051. doi: 10.3760/cma.j.issn.1001-2346.2017.10.022
    [10]
    邹鲁, 许旭东, 盛志锋, 等. 术前髂筋膜间隙阻滞持续镇痛对老年髋部骨折患者术后认知功能的影响[J]. 河北医科大学学报, 2018, 39(12): 1470-1474. doi: 10.3969/j.issn.1007-3205.2018.12.026
    [11]
    张彬枫. 心脏瓣膜置换术中rSO2监测及其与术后早期POCD的关系[D]. 武汉: 华中科技大学, 2017.
    [12]
    刘燕. 局部脑氧饱和度联合神经电生理监测用于指导颈动脉内膜剥脱术中患者血压管理的效果[D]. 石家庄: 河北医科大学, 2017.
    [13]
    高峰. 局部脑氧饱和度监测在非体外循环冠脉旁路移植患者合并颈动脉狭窄中的应用研究[D]. 郑州: 郑州大学, 2019.
    [14]
    WAGENAAR N, VAN DEN BERK D J M, LEMMERS P M A, et al. Brain activity and cerebral oxygenation after perinatal arterial ischemic stroke are associated with neurodevelopment[J]. Stroke, 2019, 50(10): 2668-2676. doi: 10.1161/STROKEAHA.119.025346
    [15]
    高燕春, 侯冠峰, 谢言虎, 等. 术前术中控制性降压对鼻内镜手术老年患者局部脑氧饱和度及术后认知功能的影响[J]. 山东医药, 2018, 58(31): 81-84. doi: 10.3969/j.issn.1002-266X.2018.31.022
    [16]
    程闪. 右美托咪定对全弓置换术患者血清S-100β蛋白、NSE及脑氧代谢的影响[D]. 郑州: 郑州大学, 2017.
    [17]
    梁仁芮, 崔晓媛, 王春燕, 等. 脑氧饱和度监测在嗜铬细胞瘤围术期中的应用[J]. 中华腔镜泌尿外科杂志: 电子版, 2020, 14(5): 343-347. doi: 10.3877/cma.j.issn.1674-3253.2020.05.006
  • Related Articles

    [1]XIONG Weijiang, LI Qian, WANG Mingzhou, PENG Xuanfu. Effect of Qingyi Decoction on toll-like receptor 4/nuclear factor-κB signaling pathway in patients with acute pancreatitis[J]. Journal of Clinical Medicine in Practice, 2025, 29(7): 71-75,81. DOI: 10.7619/jcmp.20246525
    [2]XU Hexi, SONG Hongqi, LIU Dianwen, LIU Shiju, YANG Huiju. Effect of silencing E26 transformation-specific sequence 4 on proliferation and migration of colon cancer cells by inhibiting nuclear factor-κB signaling pathway[J]. Journal of Clinical Medicine in Practice, 2025, 29(2): 38-41,47. DOI: 10.7619/jcmp.20243267
    [3]WANG Yu, YANG Jixue, GUO Dianqu, LIU Wenbin. Relationships of expression of high mobility group box 1 protein and toll-like receptor 4 in patients with clinical characteristics of refractory epilepsy and their predictive value[J]. Journal of Clinical Medicine in Practice, 2024, 28(19): 68-72, 83. DOI: 10.7619/jcmp.20241965
    [4]ZHANG Jing, MAO Ying. Value of combined assessment of serum transforming growth factor-β1, interleukin-6, toll-like receptor-4, and nuclear factor-κb in evaluating the severity of radiation pneumonitis in non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(14): 12-17. DOI: 10.7619/jcmp.20234065
    [5]ZHAO Congcong, QI Wenmei. Mechanism of Xueshuantong injection combined with intravenous thrombolysis with alteplase in treatment of patients with acute cerebral infarction based on high mobility group protein B1/Toll-like receptor 4 signaling pathway[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 41-46. DOI: 10.7619/jcmp.20234027
    [6]SHEN Yongjing, DU Baojing, SHANG Jingmin, HAN Bing, MIAO Yuanmin. Effect of toll-like receptor 4/nuclear factor κB p65 pathway on liver damage in children with rotavirus enteritis[J]. Journal of Clinical Medicine in Practice, 2024, 28(7): 63-66. DOI: 10.7619/jcmp.20240098
    [7]MO Zhisheng, XU Peiqing, LI Huanyu, HUA Guotian, CHENG Daiwei, HU Ziran. Analysis in mechanism of tradition Chinese medicine for tonifying kidney, activating blood circulation and removing dampness in treatment of knee osteoarthritis based on nuclear factor-κB signal pathway[J]. Journal of Clinical Medicine in Practice, 2022, 26(11): 87-93, 99. DOI: 10.7619/jcmp.20220631
    [8]HE Qing, LI Yang, DENG Panpan, MIAO Yufei, JIANG Lihang. Effects of Toll like receptor 4 and hepatocyte growth factor expression levels on prognosis of patients with hepatocellular carcinoma after radical resection[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 43-47. DOI: 10.7619/jcmp.20212710
    [9]WU Yuying, WANG Xiaohua. Influence of chronic obstructive pulmonary disease on the expression of toll-like receptor 2/4 signal pathway of peripheral blood mononuclear cells[J]. Journal of Clinical Medicine in Practice, 2017, (24): 16-18,22. DOI: 10.7619/jcmp.201724005
    [10]GAO Shengli, XU Liangliang, PANG Zuoliang. Expression and clinical significance of Toll-like receptor 4 and nuclear Factor-kappaB in non-small cell lung cancer tissue[J]. Journal of Clinical Medicine in Practice, 2014, (9): 68-71. DOI: 10.7619/jcmp.201409019
  • Cited by

    Periodical cited type(1)

    1. 王宏,王志刚. 心电门控下64排螺旋CT胸部CT血管成像诊断急性胸痛的临床价值分析. 现代医用影像学. 2022(04): 707-710 .

    Other cited types(0)

Catalog

    Article views (438) PDF downloads (13) Cited by(1)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return