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WANG Zijun, YANG Mukun, MAO Lele, WANG Xiaoxue, REN Zhenghong, WANG Shuowen, CUI Guangxia, HOU Zhaoxi, ZHAO Shuaihong, GU Bei, GONG Ping, LI Yan, LIU Yang, HUANG Bin, YAN Shuxiang, LI Fuying, CHEN Linfeng, YANG Min, CUI Lei, BAI Wenpei. Analysis in efficacy of autologous platelet-rich fibrin in the treatment of infertility due to intrauterine adhesions[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 6-10. DOI: 10.7619/jcmp.20210336
Citation: WANG Zijun, YANG Mukun, MAO Lele, WANG Xiaoxue, REN Zhenghong, WANG Shuowen, CUI Guangxia, HOU Zhaoxi, ZHAO Shuaihong, GU Bei, GONG Ping, LI Yan, LIU Yang, HUANG Bin, YAN Shuxiang, LI Fuying, CHEN Linfeng, YANG Min, CUI Lei, BAI Wenpei. Analysis in efficacy of autologous platelet-rich fibrin in the treatment of infertility due to intrauterine adhesions[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 6-10. DOI: 10.7619/jcmp.20210336
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Analysis in efficacy of autologous platelet-rich fibrin in the treatment of infertility due to intrauterine adhesions

  • 1.

    Department of Gynecology and Obstetrics, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038

  • 2.

    Department of Gynecology and Obstetrics, Xiehe Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430022

  • 3.

    Health Science Center of Peking University, Beijing, 100191

  • 4.

    Beijing Municipal Key Laboratory of Child Development and Nutriomics of Capital Institute of Pediatrics, Beijing, 100020

  • 5.

    Department of Gynecology and Obstetrics, Haidian Maternal and Child Health Hospital in Beijing, Beijing, 100036

  • 6.

    Department of Blood Transfusion, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038

  • 7.

    Department of Ultrasound, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038

  • 8.

    Department of Plastic Surgery, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038

More Information
  • Received Date: January 17, 2021
  • Available Online: April 05, 2021
  • Published Date: July 27, 2021
    Graphical Abstract
    • Abstract
  •   Objective   To evaluate the efficacy of autologous platelet-rich fibrin (PRF) in the treatment of infertility due to intrauterine adhesion.
      Methods   From October 2018 to October 2019, 40 patients diagnosed as intrauterine adhesion and excluded other infertility factors in Beijing Shijitan Hospital were randomly divided into PRF group and control group, with 20 cases in each group. The intervention lasted for 8 weeks. Patients in both groups underwent transcervical resection of adhesion (TCRA), and PRF was placed in the uterine cavity immediately after TCRA and 4 weeks later in the PRF group. After 8 weeks of TCRA, a second hysteroscopy was performed, and then follow-up was performed. Pregnancy rate, intrauterine adhesions score, menstruation, and endometrial thickness (EMT) were compared between two groups.
      Results   The pregnancy rate of the PRF group was 70.00%, which was significantly higher than 20.00% of the control group (P < 0.01). The adhesions score of the PRF group was significantly lower than that of the control group, and the improvement of menstrual duration was significantly better than that of the control group (P < 0.05 or P < 0.01). The menstrual volume and EMT in both groups were improved, but there were no significant differences between two groups (P>0.05).
      Conclusion   The placement of PRF combined with the TCRA can improve the pregnancy rate of infertility due to intrauterine adhesion, reduce intrauterine adhesion scores, and improve clinical symptom.
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    • References (28)
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