Relationships between serum high mobility group protein B1, soluble triggering receptor expressed on myeloid cells-like transcript 1 and acute lung injury induced by sepsis

PU Zhiqiang; MAI Chao; MOU Tianyi; ZENG Jianhui

doi:10.7619/jcmp.20212361

Journal of Clinical Medicine in Practice > 2021 > 25(24): 97-100. > DOI: 10.7619/jcmp.20212361

PU Zhiqiang, MAI Chao, MOU Tianyi, ZENG Jianhui. Relationships between serum high mobility group protein B1, soluble triggering receptor expressed on myeloid cells-like transcript 1 and acute lung injury induced by sepsis[J]. Journal of Clinical Medicine in Practice, 2021, 25(24): 97-100. DOI: 10.7619/jcmp.20212361

Citation:

PDF (750 KB)

Relationships between serum high mobility group protein B1, soluble triggering receptor expressed on myeloid cells-like transcript 1 and acute lung injury induced by sepsis

Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000

More Information

Received Date: June 07, 2021
Available Online: January 04, 2022
Published Date: December 27, 2021

Graphical Abstract

Abstract

Abstract

Objective To investigate relationships between the levels of high mobility group protein B1 (HMGB1), soluble triggering receptor expressed on myeloid cells (TREM)-like transcript 1 (sTLT-1) and acute lung injury (ALI) induced by sepsis.
Methods A total of 160 patients with sepsis were selected as research objects, according to whether ALI occurred during hospitalization, they were divided into ALI group (47 cases) and non-ALI group (113 cases). General information was collected, and HMGB1 as well as sTLT-1 levels were measured by enzyme-linked immunosorbent assay. Pearson method was used to analyze the relationships between serum HMGB1, sTLT-1 levels and related indicators in patients with ALI induced by sepsis. Multivariate Logistic regression analysis was used to explore the risk factors of ALI induced by sepsis; receiver operator characteristic (ROC) curve was used to analyze the predictive value of serum HMGB1 and sTLT-1 levels for ALI in sepsis patients.
Results The oxygenation index[p_a(O₂)/FiO₂] of the ALI group was significantly lower than that of the non-ALI group, and the levels of sequential organ failure assessment (SOFA), C-reactive protein (CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP), serum HMGB1 and sTLT-1 were significantly higher than those of the non-ALI group (P < 0.05). The levels of HMGB1 and sTLT-1 were negatively correlated with p_a(O₂)/FiO₂, and positively correlated with SOFA score, CRP and NT-proBNP (P < 0.05). The level of p_a(O₂)/FiO₂, SOFA score and serum levels of HMGB1 and sTLT-1 were risk factors for ALI induced by sepsis (P < 0.05). The area under the curve of serum HMGB1 and sTLT-1 levels in predicting the occurrence of ALI in sepsis patients was 0.910. The sensitivity and specificity of combined prediction were higher than that of serum HMGB1 or STT-1 alone.
Conclusion The serum levels of HMGB1 and sTLT-1 are increased in patients with sepsis ALI, and they can be used as potential serum markers to judge the occurrence of ALI.

FullText(HTML)

References (14)

References

[1]	邓梦芸, 史清海, 胡慧婷, 等. HMGB1和sCD14在脓毒症进展中的作用及临床应用价值[J]. 西北国防医学杂志, 2019, 40(2): 67-71. https://www.cnki.com.cn/Article/CJFDTOTAL-XBGY201902002.htm
[2]	陈艳青, 黄潇, 孔桂青, 等. HMGB1和vWF等细胞因子对脓毒症患者病情严重程度及预后评估的意义[J]. 中华危重病急救医学, 2020, 32(8): 933-937. doi: 10.3760/cma.j.cn121430-20200428-00346
[3]	MANFREDI B, MORALES-ORTÍZ J, DÍAZ-DÍAZ L M, et al. The characterization of monoclonal antibodies to mouse TLT-1 suggests that TLT-1 plays a role in wound healing[J]. Monoclon Antib Immunodiagn Immunother, 2018, 37(2): 78-86. doi: 10.1089/mab.2017.0063
[4]	SINGER M, DEUTSCHMAN C S, SEYMOUR C W, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3)[J]. JAMA, 2016, 315(8): 801-810. doi: 10.1001/jama.2016.0287
[5]	中华医学会重症医学分会. 急性肺损伤/急性呼吸窘迫综合征诊断与治疗指南(2006)[J]. 中华内科杂志, 2007, 46(5): 430-435. doi: 10.3760/j.issn:0578-1426.2007.05.037
[6]	ANDERSSON U, YANG H, HARRIS H. Extracellular HMGB1 as a therapeutic target in inflammatory diseases[J]. Expert Opin Ther Targets, 2018, 22(3): 263-277. doi: 10.1080/14728222.2018.1439924
[7]	YANG H, WANG H, ANDERSSON U. Targeting inflammation driven by HMGB1[J]. Front Immunol, 2020, 11: 484. doi: 10.3389/fimmu.2020.00484
[8]	王立鹤, 田小溪, 付国强, 等. 脓毒症患者血清miR-205和HMGB1的表达关系及意义[J]. 临床急诊杂志, 2020, 21(4): 287-291. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZLC202004006.htm
[9]	崔文娟, 李亚红, 胡国鑫, 等. 脓毒症合并急性肾损伤患者外周血TLR4、HMGB1、MFG-E8表达水平及临床意义[J]. 实用医学杂志, 2019, 18(7): 1116-1119, 1123. doi: 10.3969/j.issn.1006-5725.2019.07.023
[10]	WANG J, LI R, PENG Z, et al. HMGB1 participates in LPS?induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF-κB signaling pathways[J]. Int J Mol Med, 2020, 45(1): 61-80. http://www.ingentaconnect.com/content/sp/ijmm/2020/00000045/00000005/art00033
[11]	LI N, LIU X X, HONG M, et al. Sodium butyrate alleviates LPS-induced acute lung injury in mice via inhibiting HMGB1 release[J]. Int Immunopharmacol, 2018, 56: 242-248. doi: 10.1016/j.intimp.2018.01.017
[12]	FU R, SONG X, SU D, et al. Serum STLT-1 and bilirubin levels in patients with acute coronary syndrome and correlation with prognosis[J]. Exp Ther Med, 2018, 16(1): 241-245. doi: 10.3892/etm.2018.6137/download
[13]	SHEN L, YANG T, XIA K, et al. P-selectin (CD62P) and soluble TREM-like transcript-1(sTLT-1) are associated with coronary artery disease: a case control study[J]. BMC Cardiovasc Disord, 2020, 20(1): 387. doi: 10.1186/s12872-020-01663-2
[14]	MORALES-ORTÍZ J, DEAL V, REYES F, et al. Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model[J]. Blood, 2018, 132(23): 2495-2505. doi: 10.1182/blood-2018-03-841593

[1]	WANG Yu, YANG Jixue, GUO Dianqu, LIU Wenbin. Relationships of expression of high mobility group box 1 protein and toll-like receptor 4 in patients with clinical characteristics of refractory epilepsy and their predictive value[J]. Journal of Clinical Medicine in Practice, 2024, 28(19): 68-72, 83. DOI: 10.7619/jcmp.20241965
[2]	ZHENG Junqi, LIU Xiangyan. Distribution of pulmonary infection pathogens after lung cancer chemotherapy and diagnostic values of serum cytokeratin 19 fragment antigen, high mobility group box 1 protein and soluble hemoglobin scavenger receptor[J]. Journal of Clinical Medicine in Practice, 2024, 28(14): 7-11. DOI: 10.7619/jcmp.20241847
[3]	ZHAO Congcong, QI Wenmei. Mechanism of Xueshuantong injection combined with intravenous thrombolysis with alteplase in treatment of patients with acute cerebral infarction based on high mobility group protein B1/Toll-like receptor 4 signaling pathway[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 41-46. DOI: 10.7619/jcmp.20234027
[4]	YU Xinran, FENG Bing. Prognostic value of ratio of monocyte to high-density lipoprotein combined with high mobility group protein B1 in patients with septic myocardial injury[J]. Journal of Clinical Medicine in Practice, 2023, 27(23): 86-90, 94. DOI: 10.7619/jcmp.20232314
[5]	GAO Jianying, CAO Wenjuan, GAO Yuan. Values of D-dimer, prealbumin and soluble triggering receptor expressed on myeloid cells-1 in diagnosing severe pneumonia in children[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 108-112. DOI: 10.7619/jcmp.20223481
[6]	CHEN Yanrong, LIU Yan, WANG Shan, ZHANG Jing. Expression characteristics and detection value of histamine, soluble myeloid cell trigger receptor-1, microribonuclease-145 and high-sensitivity C-reactive protein in patients with chronic obstructive pulmonary disease and coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 1-5. DOI: 10.7619/jcmp.20223161
[7]	MENG Chao, FAN Zhiqiang, TONG Qing, ZHU Guijun, ZHU Hui. Value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1, high-sensitivity C-reactive protein combined with the Acute Physiology and Chronic Health Evaluation Ⅱ score in patients with pneumonia complicated with respiratory failure[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 88-92, 101. DOI: 10.7619/jcmp.20211056
[8]	CAI Shaoying, YE Liling, ZHANG Pingheng, MAO Haifei, LIN Guoxiong. Effects of different anesthesia methods on postoperative cognitive function and high mobility group protein B1 for patients undergoing gastrointestinal surgery[J]. Journal of Clinical Medicine in Practice, 2021, 25(4): 41-44. DOI: 10.7619/jcmp.20201189
[9]	ZHANG Ye, ZHUANG Xueming, YU Dawei, XU Dongsheng, ZHANG Li, WANG Zhongxiang, WANG Shibo. Value of serum high mobility group box 1 combined with modified Edinburgh-Scandinavian Stroke Scale score in evaluating prognosis of acute ischemic stroke patients with intravenous thrombolysis[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 23-27. DOI: 10.7619/jcmp.20201140
[10]	LIU Ping, MEI Hong. Effect of low-dose hormone on serum soluble triggering receptor expressed on myeloid cells-1, procalcitonin and CD64 in children with sepsis[J]. Journal of Clinical Medicine in Practice, 2017, (15): 41-44,48. DOI: 10.7619/jcmp.201715011

Cited By

Cited by

Periodical cited type(13)

1.	鲍颍松，盛强，王珊，贾健安，童清平. 血清sTLT-1、ESM-1对ICU患者发生输血相关急性肺损伤的诊断价值. 检验医学与临床. 2025(01): 91-95 .
2.	张建新，马尚超，宋浩，殷飞，崔俊伟. 脓毒症患者血清HMGB1、sTLT-1、NLR变化及其对并发急性肺损伤的预测价值. 海南医学. 2024(12): 1736-1739 .
3.	李志丹，杨璐瑜，曹松，陆辉志. 血清HMGB1、TIMP-2水平与脓毒症急性肾损伤预后的相关性研究. 中国急救复苏与灾害医学杂志. 2024(07): 892-895 .
4.	曾玉龙，陈玲玲，陈相. 急性大出血患者血清CCL25和sTLT-1水平表达与输血相关性急性肺损伤发生的相关性研究. 现代检验医学杂志. 2024(04): 126-130 .
5.	沃琦，汪秀英，杜腾飞，冯棋佳，戴志春，朱静文. 急性感染性腹膜炎并发急性肺损伤外周血CXCR4和sTLT-1水平. 中华医院感染学杂志. 2024(22): 3408-3411 .
6.	王晓林，李静，范志强，佟庆，黄艳丽. 血清sTLT-1、SP-D、NF-κB水平在脓毒症急性肺损伤预后评估中的价值. 西部医学. 2024(12): 1781-1785 .
7.	李丹丹，张由建，靳津鸽. 血清相关细胞因子水平变化与急性心肌梗死患者 MACE风险的相关性研究. 医学理论与实践. 2023(10): 1726-1728 .
8.	焦相赟，吴金海，李翠英，李想. 脓毒血症合并急性肾损伤患者经CRRT联合血液灌注疗法治疗的疗效评价. 中国疗养医学. 2023(07): 759-762 .
9.	杜叶子，杨皓莹，段璠. 血清HMGB1、IL-33与再生障碍性贫血患儿病情严重程度及免疫状态的相关性分析. 国际检验医学杂志. 2023(16): 1949-1952+1957 .
10.	左扬松，周素芹，王丽莉，张玉凤，季擎天，王喆，李亚伟. 脓毒症相关急性肺损伤患者趋化因子受体4、可溶性髓样细胞触发受体样转录因子-1检测价值探讨. 实用医院临床杂志. 2023(06): 84-86 .
11.	刘瑞瑞，张树柳，王军芳，田昭涛，崔云亮. 乌司他丁对脓毒症大鼠肺损伤的保护作用及机制研究. 联勤军事医学. 2023(10): 827-830 .
12.	瞿红娟，万鲁云，桂春喜，王璐. 血清CXCR4和HMGB1水平在预测急性大出血患者输血相关性急性肺损伤预后中的价值研究. 临床和实验医学杂志. 2022(13): 1390-1393 .
13.	王慧，龚园其，周仪华，蓝海兵，张啸. 青藤碱调控Nrf2/Keap1信号通路对脓毒症急性肺损伤的改善作用. 实用医学杂志. 2022(15): 1896-1900 .

Other cited types(1)

Get Citation

PDF

XML

Article views (263) PDF downloads (12) Cited by(14)

Turn off MathJax

Article Contents

Abstract

References

Relationships between serum high mobility group protein B1, soluble triggering receptor expressed on myeloid cells-like transcript 1 and acute lung injury induced by sepsis