Objective To investigate relationships between the levels of high mobility group protein B1 (HMGB1), soluble triggering receptor expressed on myeloid cells (TREM)-like transcript 1 (sTLT-1) and acute lung injury (ALI) induced by sepsis.
Methods A total of 160 patients with sepsis were selected as research objects, according to whether ALI occurred during hospitalization, they were divided into ALI group (47 cases) and non-ALI group (113 cases). General information was collected, and HMGB1 as well as sTLT-1 levels were measured by enzyme-linked immunosorbent assay. Pearson method was used to analyze the relationships between serum HMGB1, sTLT-1 levels and related indicators in patients with ALI induced by sepsis. Multivariate Logistic regression analysis was used to explore the risk factors of ALI induced by sepsis; receiver operator characteristic (ROC) curve was used to analyze the predictive value of serum HMGB1 and sTLT-1 levels for ALI in sepsis patients.
Results The oxygenation indexpa(O2)/FiO2 of the ALI group was significantly lower than that of the non-ALI group, and the levels of sequential organ failure assessment (SOFA), C-reactive protein (CRP), N-terminal pro-brain natriuretic peptide (NT-proBNP), serum HMGB1 and sTLT-1 were significantly higher than those of the non-ALI group (P < 0.05). The levels of HMGB1 and sTLT-1 were negatively correlated with pa(O2)/FiO2, and positively correlated with SOFA score, CRP and NT-proBNP (P < 0.05). The level of pa(O2)/FiO2, SOFA score and serum levels of HMGB1 and sTLT-1 were risk factors for ALI induced by sepsis (P < 0.05). The area under the curve of serum HMGB1 and sTLT-1 levels in predicting the occurrence of ALI in sepsis patients was 0.910. The sensitivity and specificity of combined prediction were higher than that of serum HMGB1 or STT-1 alone.
Conclusion The serum levels of HMGB1 and sTLT-1 are increased in patients with sepsis ALI, and they can be used as potential serum markers to judge the occurrence of ALI.
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