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LING Bofan, JIANG Yuqi, HOU Qian, SHI Zheng, JIN Zhichao. Mechanism of Jianpi Huayu Decoction in improving blood hypercoagulability of patients with advanced gastric cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 96-101, 105. DOI: 10.7619/jcmp.20211647
Citation: LING Bofan, JIANG Yuqi, HOU Qian, SHI Zheng, JIN Zhichao. Mechanism of Jianpi Huayu Decoction in improving blood hypercoagulability of patients with advanced gastric cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 96-101, 105. DOI: 10.7619/jcmp.20211647
shu

Mechanism of Jianpi Huayu Decoction in improving blood hypercoagulability of patients with advanced gastric cancer

  • 1.

    Department of Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210029

  • 2.

    The First Clinical Medical College of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210023

  • 3.

    Department of Traditional Chinese Medicine, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, 210009

  • 4.

    Institute of TCM Literatures of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, 210023

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  • Received Date: April 18, 2021
  • Available Online: July 07, 2021
  • Published Date: July 14, 2021
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    • Abstract
  •   Objective  To observe the effect of Jianpi Huayu Decoction on coagulation indexes, tissue factor (TF), inflammation indexes and platelet aggregation test in stages Ⅲ to Ⅳ gastric cancer patients with blood hypercoagulability.
      Methods  Totally 50 patients were randomly divided into experimental group (n=25) and control group (n=25). The experimental group received Jianpi Huayu Decoction combined with basic treatment for tumor, while the control group only received basic treatment for tumor, and both groups were treated for (42±2) days. On the 1st day, the (21±2) day and (42±2) day, the subjects were interviewed and the results were statistically analyzed.
      Results  ① After 2 cycles of treatment, the levels of D-Dimer (D-D) and fibrinogen (FIB) in the experimental group were significantly lower than those in the control group, while the thrombin time (TT) was significantly longer than that in the control group (P < 0.01). ② After treatment, tissue factor (TF) in the experimental group was significantly lower than that in the control group (P < 0.01). ③ Level of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the experimental group were significantly lower than those in the control group (P < 0.01). ④ FIB was positively correlated with TF (r=0.447, P < 0.01), and the changes after treatment also showed a significant positive correlation between two indexes (r=0.434, P < 0.05). ⑤ There was a significant positive correlation between FIB and IL-1β (r=0.357, P < 0.05), and the changes after treatment also showed a significant positive correlation between two indexes (r=0.555, P < 0.05).
      Conclusion  Jianpi Huayu Decoction can improve the blood hypercoagulability in patients with advanced gastric cancer by reducing the expressions of TF and IL-1β.
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    • References (34)
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