Mechanism of Jianpi Huayu Decoction in improving blood hypercoagulability of patients with advanced gastric cancer

  Objective  To observe the effect of Jianpi Huayu Decoction on coagulation indexes, tissue factor (TF), inflammation indexes and platelet aggregation test in stages Ⅲ to Ⅳ gastric cancer patients with blood hypercoagulability.

  Methods  Totally 50 patients were randomly divided into experimental group (n=25) and control group (n=25). The experimental group received Jianpi Huayu Decoction combined with basic treatment for tumor, while the control group only received basic treatment for tumor, and both groups were treated for (42±2) days. On the 1^st day, the (21±2) day and (42±2) day, the subjects were interviewed and the results were statistically analyzed.

  Results  ① After 2 cycles of treatment, the levels of D-Dimer (D-D) and fibrinogen (FIB) in the experimental group were significantly lower than those in the control group, while the thrombin time (TT) was significantly longer than that in the control group (P < 0.01). ② After treatment, tissue factor (TF) in the experimental group was significantly lower than that in the control group (P < 0.01). ③ Level of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the experimental group were significantly lower than those in the control group (P < 0.01). ④ FIB was positively correlated with TF (r=0.447, P < 0.01), and the changes after treatment also showed a significant positive correlation between two indexes (r=0.434, P < 0.05). ⑤ There was a significant positive correlation between FIB and IL-1β (r=0.357, P < 0.05), and the changes after treatment also showed a significant positive correlation between two indexes (r=0.555, P < 0.05).

  Conclusion  Jianpi Huayu Decoction can improve the blood hypercoagulability in patients with advanced gastric cancer by reducing the expressions of TF and IL-1β.