Objective To investigate the change of serum free prostate specific antigen (fPSA) in patients with benign prostatic hyperplasia (BPH) after transurethral enucleative resection of prostate (TUERP) and its relationships with prostate volume and prognosis.
Methods A total of 105 BPH patients with TUERP were divided into small volume group (n=49), medium volume group (n=36) and large volume group (n=20) according to preoperative prostate volume. The levels of serum fPSA were compared among three groups before operation and 1 day, 3 and 7 days after operation. The relationship between preoperative serum fPSA level and prostate volume was analyzed by Pearson method. The clinical materials and the level of serum fPSA at 7 days after operation were compared among BPH patients with different prognosis. Logistic regression analysis was used to explore the influencing factors of poor prognosis in BPH patients.
Results Before operation and 1 day after operation, the levels of serum fPSA in the small volume group, the medium volume group and the large volume group increased significantly (P < 0.05). Pearson analysis showed that there was a positive correlation between preoperative serum fPSA level and prostate volume in patients with BPH (r=0.598, P < 0.05). Compared with the good prognosis group (n=79), the high density lipoprotein cholesterol (HDL-C), blood glucose, serum fPSA level at 7 days after operation and the ratio of cases with hypertension in the poor prognosis group (n=26) were significantly higher (P < 0.05). Logistic regression analysis showed that HDL-C, blood glucose, hypertension and serum fPSA at 7 days after operation were the risk factors for the prognosis of BPH patients (P < 0.05).
Conclusion The serum fPSA level is highly expressed in BPH patients, which may be involved in the pathogenesis of BPH. The serum fPSA level at 7 days after operation can be used to evaluate the prognosis of BPH patients after TUERP.
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