Correlations between type 2 diabetes patients with left ventricular hypertrophy and levels of inflammatory markers

  Objective  To investigate the correlations between type 2 diabetes (T2DM) patients with left ventricular hypertrophy (LVH) and neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV).

  Methods  A total of 216 patients with T2DM were enrolled in the study. According to left ventricular mass index(LVMI), these patients were divided into LVH group(n=103) and non-LVH group(n=113). The general clinical data, blood routine indicators, and biochemical indicators of the two groups were compared.

  Results  The levels of triglycerides (TG), NLR, PLR, MPV and 24h urine protein, albumin-to-creatinine ratio(UACR) in the LVH group were higher than those in the non-LVH group, high-density lipoprotein cholesterol (HDL-C) and left ventricular ejection fraction(LVEF) levels were lower than that of the non-LVH group (P < 0.05). T2DM combined with LVH was positively correlated with TG, NLR, PLR, MPV and 24 h urine protein and UACR index levels (r_s=0.192, 0.490, 0.442, 0.313, 0.205, 0.167, P < 0.05), and was negatively correlated with HDL-C and LVEF index levels (r_s=-0.214, -0.232, P < 0.05). NLR, PLR and MPV are independent influencing factors of T2DM patients with LVH (P < 0.05). The areas under the curve(AUC) of NLR, PLR and MPV forecasted T2DM with LVH were 0.783 (95%CI, 0.723 to 0.844), 0.756 (95%CI, 0.692 to 0.819) and 0.681 (95%CI, 0.610to0.751) respectively, the best cut-off values were 1.97, 97.37 and 11.15 fL respectively, the sensitivities were 87.4%, 84.5% and 62.1%, and the specificities were 61.9%, 57.5% and 61.8%.

  Conclusion  The levels of NLR, PLR and MPV in T2DM patients with LVH are significantly increased. NLR, PLR, and MPV can be used as predictors of T2DM combined with LVH, and the predictive value of NLR is better than PLR and MPV.