Clinical significance of ticagrelor in treatment of patients with high inflammatory response after emergency percutaneous coronary intervention

CHEN Zhixian; ZHU Zongcheng; SHENG Xiaodong; JIN Jing

doi:10.7619/jcmp.20213518

Journal of Clinical Medicine in Practice > 2022 > 26(10): 68-72, 76. > DOI: 10.7619/jcmp.20213518

CHEN Zhixian, ZHU Zongcheng, SHENG Xiaodong, JIN Jing. Clinical significance of ticagrelor in treatment of patients with high inflammatory response after emergency percutaneous coronary intervention[J]. Journal of Clinical Medicine in Practice, 2022, 26(10): 68-72, 76. DOI: 10.7619/jcmp.20213518

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Clinical significance of ticagrelor in treatment of patients with high inflammatory response after emergency percutaneous coronary intervention

Department of Cardiology, Changshou City Second People′s Hospital of Jiangsu Province, Suzhou, Jiangsu, 215500

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Received Date: August 30, 2021
Available Online: May 24, 2022

Graphical Abstract

Abstract

Abstract

Objective
To investigate clinical significance of ticagrelor in treatment of patients with high inflammatory response after emergency percutaneous coronary intervention (PCI).
Methods
A total of 100 patients diagnosed with acute inferior myocardial infarction and high levels of hypersensitive C-reactive protein (hs-CRP) who underwent emergency PCI were selected as study objects.These patients were randomly divided into two groups according to different medication methods.The control group was given antiplatelet therapy by clopidogrel for 12 months after PCI, while the observation group was given antiplatelet therapy byticagrelor for 12 months after PCI.The levels of serum inflammatory factors of two groups were compared before operation and 1 month after operation.Twelve months after PCI, coronary angiography and coronary ultrasound were reviewed to observe the proportion of patients with in-stent restenosis and new coronary artery disease.
Results
The levels of hs-CRP, interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), and advanced glycation end products (AGEs) after operation in the two group were lower than those before treatment, and were significantly lower in the observation group than those in the control group (P < 0.05).Compared with the control group, the proportions of stent restenosis, new right coronary artery disease and other new coronary artery disease in the observation group were lower, and the differences were statistically significant (P < 0.05).After 12 months of treatment, coronary artery lesions was significantly correlated with the levels of hs-CRP, IL-6, TNF-α and AGEs 1 month after PCI (P < 0.05).There was no significant difference in occurrence of adverse reactions between two groups during treatment (P>0.05).
Conclusion
Ticagrelor can effectively reduce the levels of inflammatory factors in patients with high inflammation response after emergency PCI, and reduce occurrence of long-term coronary events compared with clopidogrel.
- ticagrelor,
- clopidogrel,
- acute inferior myocardial infarction,
- percutaneous coronary intervention,
- inflammatory factors

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References (16)

References

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Clinical significance of ticagrelor in treatment of patients with high inflammatory response after emergency percutaneous coronary intervention