Citation: | GAO Xue, WANG Yonghuai, WANG Yao, LIANG Jie, WEI Fengying, LOU Zhe. Diagnostic value of Gray-Weale classification in symptomatic carotid plaque[J]. Journal of Clinical Medicine in Practice, 2022, 26(13): 41-44. DOI: 10.7619/jcmp.20220075 |
To investigate the distribution characteristics and clinical application value of Gray-Weale (GW) classification of symptomatic carotid plaque.
Sixty inpatients with carotid artery bifurcation atherosclerosis (AS) plaques undergoing carotid doppler ultrasonography were randomly selected. Patients were divided into symptomatic group (n=32) and asymptomatic group (n=28) according to whether they had experienced an ischemic cerebrovascular event within 6 months. The GW classification of patients'plaques was analyzed. Carotid artery bifurcation plaque thickness, plaque length and the number of plaque were evaluated by ultrasound.
A total of 60 carotid bifurcation plaques were analyzed by GW classification, 32 plaques in symptom group, including 6 with typeⅠ, 17 with type Ⅱ, 7 with type Ⅲ, and 2 with type Ⅴ; there were 28 plaques in asymptomatic group, including 2 plaques in type Ⅰ, 7 plaques in type Ⅱ, 17 plaques in type Ⅲ, 2 plaques in type Ⅳ. There was statistically significant difference between the two groups in GW classification (P < 0.05). The plaque thickness in the symptomatic group was significantly higher than that in the asymptomatic group (P < 0.05). There was a negative correlation between plaque GW classification and plaque thickness (r=-0.53, P < 0.01). Cohen's Kappa consistency test results showed that Cohen's Kappa coefficient was 0.874 (95%CI, 0.766 2 to 0.981 8, P < 0.001).
GW plaque classification has good stability and repeatability in evaluating echo characteristics of carotid atherosclerotic plaques. Plaque GW classification can be used as an effective method to screen symptomatic carotid plaque.
[1] |
《中国脑卒中防治报告》编写组. 《中国脑卒中防治报告2019》概要[J]. 中国脑血管病杂志, 2020, 17(5): 272-281.
|
[2] |
LYU Q, TIAN X J, DING Y F, et al. Evaluation of carotid plaque rupture and neovascularization by contrast-enhanced ultrasound imaging: an exploratory study based on histopathology[J]. Transl Stroke Res, 2021, 12(1): 49-56. doi: 10.1007/s12975-020-00825-w
|
[3] |
HUIBERS A, DE BORST G J, WAN S, et al. Non-invasive carotid artery imaging to identify the vulnerable plaque: current status and future goals[J]. Eur J Vasc Endovasc Surg, 2015, 50(5): 563-572. doi: 10.1016/j.ejvs.2015.06.113
|
[4] |
华扬, 惠品晶, 邢瑛琦. 中国脑卒中血管超声检查指导规范[J]. 中华医学超声杂志: 电子版, 2015, 12(8): 599-610. doi: 10.3877/cma.j.issn.1672-6448.2015.08.004
|
[5] |
GRAY-WEALE A C, GRAHAM J C, BURNETT J R, et al. Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology[J]. J Cardiovasc Surg (Torino), 1988, 29(6): 676-681.
|
[6] |
GEROULAKOS G, RAMASWAMI G, NICOLAIDES A, et al. Characterization of symptomatic and asymptomatic carotid plaques using high-resolution real-time ultrasonography[J]. Br J Surg, 1993, 80(10): 1274-1277.
|
[7] |
LOU Z, YANG J, TANG L, et al. Shear wave elastography imaging for the features of symptomatic carotid plaques: a feasibility study[J]. J Ultrasound Med, 2017, 36(6): 1213-1223. doi: 10.7863/ultra.16.04073
|
[8] |
ADDIS D R, TOWNSLEY M M. Implications of carotid arterial plaque assessment by ultrasound for the cardiothoracic anesthesiologist: an overview of the 2020 American society of echocardiography recommendations for the assessment of carotid arterial plaque by ultrasound for the characterization of atherosclerosis and evaluation of cardiovascular risk[J]. J Cardiothorac Vasc Anesth, 2021, 35(4): 987-990. doi: 10.1053/j.jvca.2020.12.006
|
[9] |
SPENCE J D. Measurement of carotid plaque burden[J]. Curr Opin Lipidol, 2020, 31(5): 291-298. doi: 10.1097/MOL.0000000000000706
|
[10] |
VERGALLO R, PORTO I, D'AMARIO D, et al. Coronary atherosclerotic phenotype and plaque healing in patients with recurrent acute coronary syndromes compared with patients with long-term clinical stability: an in vivo optical coherence tomography study[J]. JAMA Cardiol, 2019, 4(4): 321-329. doi: 10.1001/jamacardio.2019.0275
|
[11] |
SHIMOKADO A, MATSUO Y, KUBO T, et al. In vivo optical coherence tomography imaging and histopathology of healed coronary plaques[J]. Atherosclerosis, 2018, 275: 35-42. doi: 10.1016/j.atherosclerosis.2018.05.025
|
[12] |
SANGIORGI G, ROVERSI S, BIONDI ZOCCAI G, et al. Sex-related differences in carotid plaque features and inflammation[J]. J Vasc Surg, 2013, 57(2): 338-344. doi: 10.1016/j.jvs.2012.07.052
|
[13] |
BRINJIKJI W, RABINSTEIN A A, LANZINO G, et al. Ultrasound characteristics of symptomatic carotid plaques: a systematic review and meta-analysis[J]. Cerebrovasc Dis, 2015, 40(3/4): 165-174.
|
[14] |
BEG F, REHMAN H, AL-MALLAH M H. The vulnerable plaque: recent advances in computed tomography imaging to identify the vulnerable patient[J]. Curr Atheroscler Rep, 2020, 22(10): 58. doi: 10.1007/s11883-020-00879-z
|
[15] |
HOWARD D P, VAN LAMMEREN G W, ROTHWELL P M, et al. Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk[J]. Stroke, 2015, 46(1): 182-189. doi: 10.1161/STROKEAHA.114.007221
|