Objective To investigate the expression and significance of serum interferon-γ (IFN-γ), serum amyloid A (SAA) and soluble fms-like tyrosine kinase-1 (sFlt-1) in patients with unexplained recurrent spontaneous abortion (URSA).
Methods A total of 100 URSA patients were prospectively selected as study group, and 60 normal early pregnant women who underwent artificial abortion during the same period were selected as control group. Serum IFN-γ, SAA and sFlt-1 were detected in both groups, the expressions of serum IFN-γ, SAA and sFlt-1 were compared between the two groups. Receiver operator characteristic (ROC) curve was used to analyze the predictive value of serum IFN-γ, SAA and sFlt-1 in URSA patients.
Results There were significant differences in age, number of deliveries and number of spontaneous abortion between the two groups (P<0.05). The levels of serum IFN-γ, SAA and sFlt-1 in the study group were significantly higher than those in the control group (P<0.05). Serum IFN-γ was positively correlated with SAA and sFlt-1 (r=0.671, 0.728, P<0.05); SAA was positively correlated with sFlt-1 (r=0.708, P<0.05). Age, IFN-γ, SAA and sFlt-1 were the influencing factors of URSA occurrence (P<0.05). ROC results showed that the area under the curve (AUC) of serum IFN-γ, SAA and sFlt-1 for predicting URSA were 0.877, 0.862 and 0.850. The sensitivity and specificity of serum IFN-γ were 80.0% and 85.0% respectively. The sensitivity and specificity of SAA were 78.0% and 88.3% respectively. The sensitivity and specificity of sFlt-1 were 70.0% and 90.0% respectively.
Conclusion Increased serum IFN-γ, SAA and sFlt-1 levels are the risk factors for URSA, and have certain predictive value for URSA.
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