Influence of early goal-directed sedation strategy on incidence of delirium and sedation effect in critically ill patients with mechanical ventilation

Objective To investigate the influence of early goal-directed sedation strategy (EGDS) on the incidence of delirium and sedation effect in critically ill patients with mechanical ventilation.

Methods A total of 200 hospitalized patients in the Intensive Care Unit (ICU) from July 2019 to July 2021 were selected as research objects, and they were randomly divided into observation group and control group, with 100 cases in each group. The control group was conducted with standardized sedation strategy, and the observation group was conducted with EGDS strategy. After intervention, the ratio of superficial sedation, incidence of delirium, mechanical ventilation time, hospital stay and the total dose per capita of midazolam were compared between the two groups.

Results After intervention, the rate of superficial sedation in the observation group was 56.00%, which was significantly higher than 37.00% in the control group (P < 0.05). The mechanical ventilation time, hospital stay and incidence of delirium in the observation group were (7.68±3.31) h, (10.17±3.88) d and 14.00% respectively, which were significantly shorter or lower than (11.72±3.63) h, (19.21±4.05) d and 35.00% in the control group (P < 0.05). The total dose per capita of midazolam in the observation group was (2.55±1.46) mg, which was significantly lower than (8.27±2.05) mg in the control group (P < 0.05).

Conclusion EGDS can maintain the status of superficial sedation in patients, reduce the dosage of sedatives and the incidence of delirium, and shorten the mechanical ventilation time and hospital stay.