Single center study on clinical distribution and drug resistance analysis of <i>Staphylococcus aureus</i>

WANG Shanshan; XU Li; CHEN Zehui; LI Ling; LIU Yun

doi:10.7619/jcmp.20221457

Journal of Clinical Medicine in Practice > 2022 > 26(19): 83-86, 91. > DOI: 10.7619/jcmp.20221457

WANG Shanshan, XU Li, CHEN Zehui, LI Ling, LIU Yun. Single center study on clinical distribution and drug resistance analysis of Staphylococcus aureus[J]. Journal of Clinical Medicine in Practice, 2022, 26(19): 83-86, 91. DOI: 10.7619/jcmp.20221457

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Single center study on clinical distribution and drug resistance analysis of Staphylococcus aureus

1.
Department of Laboratory, the First Affiliated Hospital of Naval Medical University of the Chinese People′s Liberation Army, Shanghai, 200433
2.
Department of Laboratory, Shidong Hospital of Yangpu District of Shanghai, Shanghai, 200438

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Received Date: May 05, 2022
Available Online: October 23, 2022

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Abstract

Abstract

Objective
To analyze the clinical distribution characteristics and drug-resistant condition of Staphylococcus aureus (SA) in the First Affiliated Hospital of Naval Medical University of the Chinese People′s Liberation Army (called our hospital in the following text) from 2016 to 2020, so as to provide a basis for rational clinical application of antibacterial agents.
Methods
SA strains isolated from samples of 1 575 patients in our hospital from January 2016 to December 2020 were retrospectively analyzed. WHONET 5.6 software and SPSS software were used to statistically analyze the department distribution, sample source and drug resistance of the strains.
Results
A total of 1 784 strains were isolated from the samples, including 926 strains (51.9%) of methicillin resistant Staphylococcus aureus (MRSA). The highest detection rate of SA occurred in burn department (15.5%), followed by respiratory department (7.3%) and department of plastic surgery (5.9%). SA strains were mainly derived from respiratory tract samples (44.6%), followed by secretion (30.4%) and blood (5.6%). From year of 2016 to 2020, the resistance rate of SA to penicillin was more than 90%, resistance rates were more than 44.1% to 62.4%to erythromycin and clindamycin, and were more than 29.2% to 44.1%to tetracycline, ciprofloxacin, levofloxacin and moxifloxacin. The overall drug resistance rate of MRSA strains was generally higher than that of SA strains. No SA strains were found to be resistant to tigecycline, linezolid and vancomycin.
Conclusion
The detection rate of SA and MRSA in our hospital is high. Regular monitoring of their clinical distribution and drug resistance has high clinical value for the rational use of antibiotics and the prevention and control of nosocomial infection.
- Staphylococcus aureus,
- methicillin resistant Staphylococcus aureus,
- infection,
- clinical distribution,
- antibiotics,
- drug resistance

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