Drug resistance and efflux pump gene in <i>Acinetobacter</i> <i>baumannii</i> in department of geriatrics

HOU Panfei; YU Jiufeng; ZHOU Suqin

doi:10.7619/jcmp.20213771

Journal of Clinical Medicine in Practice > 2022 > 26(7): 26-28. > DOI: 10.7619/jcmp.20213771

HOU Panfei, YU Jiufeng, ZHOU Suqin. Drug resistance and efflux pump gene in Acinetobacter baumannii in department of geriatrics[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 26-28. DOI: 10.7619/jcmp.20213771

Citation:

PDF (622 KB)

Drug resistance and efflux pump gene in Acinetobacter baumannii in department of geriatrics

1.
Department of Laboratory Medicine, Lianshui People′s Hospital Affiliated Kangda College of Nanjing Medical University, Lianshui, Jiangsu, 223400
2.
Department of Pharmacy, Lianshui People′s Hospital Affiliated Kangda College of Nanjing Medical University, Lianshui, Jiangsu, 223400

More Information

Received Date: September 17, 2021
Available Online: April 14, 2022
Published Date: April 14, 2022

Graphical Abstract

Abstract

Abstract

Objective To observe the drug resistance of Acinetobacter baumannii to commonly used antibiotics in department of geriatrics and status of efflux pump gene-carrying so as to provide theoretical basis for prevention and control of nosocomial infection and clinical rational application of drugs.
Methods A total of 85 non-repetitive strains of Acinetobacter baumannii were collected and isolated from geriatric patients, disk dilution method was used to determine their drug sensitivity to 15 antibiotics commonly used in clinic. The adeB, adeG and adeJ genes-carrying were tested by polymerase chain reaction(PCR) method.
Results The sensitive rate of Acinetobacter baumannii was 100.0% to polymyxin B, 29.4% to minocycline, 35.3% to cefoperazone-sulbactam, 38.8% to amikacin and 41.2% to gentamicin, which had lower sensitive rates. Drug resistance rate of Acinetobacter baumannii to other detected antibiotics was over 50.0%, with 49 strains (57.6%) of multidrug-resistant bacteria. PCR results showed that the positive rates of adeB, adeG and adeJ genes in multi-drug resistant efflux pump gene-carrying Acinetobacter baumannii were 73.5%, 77.6% and 71.4%, respectively, which were significantly higher than those in non-multidrug-resistant bacteria (P < 0.05).
Conclusion The drug resistance of Acinetobacter baumannii in geriatrics is serious, and multi-drug resistance is related to carrying adeB, adeG and adeJ genes.
- Acinetobacter baumannii,
- resistance,
- efflux pump,
- department of geriatrics,
- multi-drug resistance,
- drug sensitive test

FullText(HTML)

References (12)

References

[1]	谭莉, 曾莉怡, 吴健, 等. 老年患者耐碳青霉烯类鲍曼不动杆菌感染的耐药性及预后影响因素分析[J]. 中国实用医刊, 2021, 48(1): 21-24. doi: 10.3760/cma.j.cn115689-20200810-03906
[2]	陈肖, 王立坤, 刘卫东, 等. 鲍曼不动杆菌的致病因子和耐药机制[J]. 国际流行病学传染病学杂志, 2021, 48(2): 162-165. doi: 10.3760/cma.j.cn331340-20200826-00272
[3]	Clinical and Laboratory Standards Institute. M100-S30. Performance standards for antimicrobial susceptibility testing: thirty edition[S]. Wayne, PA: CLSI, 2020.
[4]	周玉, 龚美亮, 闫中强, 等. 分离自老年病房的鲍曼不动杆菌耐药机制初步研究[J]. 现代生物医学进展, 2019, 19(1): 99-103. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201901022.htm
[5]	陈亚男, 李爱民, 刘克喜, 等. ICU老年患者呼吸机相关性肺炎合并耐药菌感染流行病学特征及影响因素[J]. 中国老年学杂志, 2021, 41(8): 1642-1645. doi: 10.3969/j.issn.1005-9202.2021.08.023
[6]	全国细菌耐药监测网. 全国细菌耐药监测网2014—2019年老年患者常见临床分离细菌耐药性监测报告[J]. 中国感染控制杂志, 2021, 20(2): 112-123. https://www.cnki.com.cn/Article/CJFDTOTAL-GRKZ202102002.htm
[7]	张辉, 张小江, 徐英春, 等. 2005—2014年CHINET不动杆菌属细菌耐药性监测[J]. 中国感染与化疗杂志, 2016, 16(4): 429-436. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201604010.htm
[8]	NIE X M, HUANG P H, YE Q F, et al. The distribution, drug resistance, and clinical characteristics of Acinetobacter baumannii infections in solid organ transplant recipients[J]. Transplant Proc, 2015, 47(10): 2860-2864. doi: 10.1016/j.transproceed.2015.09.037
[9]	AYKOTA M R, SARI T, YILMAZ S. Successful treatment of extreme drug resistant Acinetobacter baumannii infection following a liver transplant[J]. J Infect Dev Ctries, 2020, 14(4): 408-410. doi: 10.3855/jidc.11842
[10]	戴晓玥, 吴亮, 阴晴, 等. 肺炎患者痰液分离鲍曼不动杆菌耐药基因分析[J]. 临床检验杂志, 2020, 38(1): 60-65. https://www.cnki.com.cn/Article/CJFDTOTAL-LCJY202001020.htm
[11]	NASR P. Genetics, epidemiology, and clinical manifestations of multidrug-resistant Acinetobacter baumannii[J]. J Hosp Infect, 2020, 104(1): 4-11. https://pubmed.ncbi.nlm.nih.gov/31589900/
[12]	ZHU L J, PAN Y, GAO C Y, et al. Distribution of carbapenemases and efflux pump in carbapenem-resistance Acinetobacter baumannii[J]. Ann Clin Lab Sci, 2020, 50(2): 241-246. https://pubmed.ncbi.nlm.nih.gov/32366563/

[1]	ZHANG Liping, LIU Xiangjie, LIU Xiaoxia, WEI Ting, WANG Yan, LI Qian. Epidemic characteristics and disease burden of drug-resistant tuberculosis cases in the elderly in Wuhan[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 30-33. DOI: 10.7619/jcmp.20244924
[2]	CHEN Hui, ZHANG Li, LU Chen, CAI Xindi. Establishment and validation of a Nomogram predictionmodel for risk of multi-drug resistant infection after operation of cerebral hemorrhage[J]. Journal of Clinical Medicine in Practice, 2024, 28(8): 45-49, 54. DOI: 10.7619/jcmp.20234252
[3]	ZHOU Fen, ZHANG Yubin, XIAO Meifang. Analysis of Mycoplasma genitalium infection and drug resistance in Haikou area of Hainan Province[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 18-21. DOI: 10.7619/jcmp.20214298
[4]	CHENG Jie, CHEN Xin, ZHU Zhenzhong, ZHAO Xiaoli. Multi-drug resistance in elderly patients with pulmonary infection and respiratory failure undergoing mechanical ventilation and related factor analysis[J]. Journal of Clinical Medicine in Practice, 2021, 25(14): 20-23. DOI: 10.7619/jcmp.20211680
[5]	SONG Huajie, GE Xiaoqing, ZHANG Jin, HOU Lu, YANG Kunpeng. Distribution of pathogenic bacteria and drug resistance in patients with postoperative nosocomial infections in Department of Thoracic Surgery[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 59-62, 68. DOI: 10.7619/jcmp.20201267
[6]	CHEN Liangshan. Analysis on distribution of pathogenic bacteria and drug sensitivity in patients with urogenital tract infection[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 66-69. DOI: 10.7619/jcmp.202022019
[7]	XU Anping. Distribution characteristics and drug resistance of pathogens in patients with infectious interstitial pneumonia[J]. Journal of Clinical Medicine in Practice, 2020, 24(19): 26-28,33. DOI: 10.7619/jcmp.202019008
[8]	LIU Jinna. Value of minimum inhibitory concentration method of microliquid culture medium versus Roche's proportional method in drug susceptibility test of mycobacterium tuberculosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 28-30,40. DOI: 10.7619/jcmp.202017007
[9]	ZHOU Jun, TANG Hongping, ZHU Xiaoxia. Role of nursing strategy of daily replacement of medical fabric in the prevention and control of nosocomial infection in patients with infection or colonization of multi-drug resistant bacteria[J]. Journal of Clinical Medicine in Practice, 2019, 23(22): 17-19. DOI: 10.7619/jcmp.201922006
[10]	ZHANG Keliang, LIU Erping, JIANG Yuqing. Detection and drug resistance analysis of mycoplasma infection in 9 029 female genital infection[J]. Journal of Clinical Medicine in Practice, 2013, (19): 163-164. DOI: 10.7619/jcmp.201319063

Cited By

Cited by

Periodical cited type(6)

1.	杨可非，刘文靖，周新尧，姜泉. 基于“体脏合痹”理论探讨干燥综合征病机论治. 中国中医基础医学杂志. 2025(02): 236-240 .
2.	邹怡萌，邹纯朴，陈晓，朱杨壮壮，苏琳，胥孜杭. 基于“肺主皮毛”理论的中西联系与思考. 北京中医药大学学报. 2024(01): 42-48 .
3.	张盈，杨波，蔡新利，王霜，王迎春. 干燥综合征患者血清HMGB1、Progranulin与NK细胞亚群和间质性肺疾病的关系研究. 现代生物医学进展. 2024(20): 3867-3869 .
4.	陈嘉琪，杨建英，吴子华，张丽宁，张燕，胡琪，贺倩，黄子玮，余新波，罗静，陶庆文. 原发性干燥综合征合并间质性肺病的中医证候特点及相关因素分析. 中国实验方剂学杂志. 2023(08): 66-72 .
5.	彭艳茹，闫世艳，罗成，张宁，李睿，王玉光. 中医药联合西医治疗干燥综合征相关间质性肺疾病的临床疗效和安全性的系统评价. 中国医院用药评价与分析. 2023(08): 980-984 .
6.	王菲，时美红. 原发性干燥综合征患者唇腺组织中BTB/POZ结构域蛋白7及基质金属蛋白酶-9的表达与自身抗体的关系. 实用临床医药杂志. 2022(21): 98-102 . 本站查看

Other cited types(0)

Get Citation

PDF

XML

Article views (237) PDF downloads (15) Cited by(6)

Turn off MathJax

Article Contents

Abstract

References

Drug resistance and efflux pump gene in Acinetobacter baumannii in department of geriatrics