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LI Xiaoluan, WANG Ye, CHEN Cheng. Efficacy of continuous positive airway pressure combined with medicine in treatment of type 2 diabetes mellitus patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Clinical Medicine in Practice, 2022, 26(22): 52-55, 59. DOI: 10.7619/jcmp.20222391
Citation: LI Xiaoluan, WANG Ye, CHEN Cheng. Efficacy of continuous positive airway pressure combined with medicine in treatment of type 2 diabetes mellitus patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Clinical Medicine in Practice, 2022, 26(22): 52-55, 59. DOI: 10.7619/jcmp.20222391
shu

Efficacy of continuous positive airway pressure combined with medicine in treatment of type 2 diabetes mellitus patients with obstructive sleep apnea hypopnea syndrome

  • 1.

    Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, Qinghai, 810007

  • 2.

    Department of Pulmonary and Critical Care Medicine, General Hospital of Xining First Medical Group of Qinghai Province, Xining, Qinghai, 810099

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  • Received Date: August 03, 2022
  • Available Online: December 01, 2022
    Graphical Abstract
    • Abstract
  • Objective 

    To observe the clinical efficacy of continuous positive airway pressure (CPAP) combined with montelukast and liraglutide in the treatment of type 2 diabetes mellitus (T2DM) patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).

    Methods 

    A total of 123 T2DM patients complicating OSAHS were randomly divided into control group (n=62) and observation group (n=61). The control group was orally taken montelukast sodium and percutaneous injection of liraglutide, and the observation group received CPAP on the basis of the control group. The serum levels of 8-iso-prostaglandin F2α (8-iso-PGF2α), interleukin-6 (IL-6), CXC-chemokine ligand 13 (CXCL13), sleep breathing parameters, cognitive ability, sleep quality and OSAHS severity were observed and compared between the two groups before and after treatment.

    Results 

    After treatment, the apnea hypopnea index (AHI), longest apnea time and lowest pulse volume oxygen saturation in the observation group were (10.41±2.58) times/h, (41.07±5.69) s and (88.09±6.58)%, respectively, which were lower, shorter or higher than (14.29±2.62) times/h, (50.98±3.15) s and (72.36± 4.26)%, respectively of the control group (P < 0.05). After treatment, the serum levels of 8-iso-PGF2α, IL-6 and CXCL13 in the observation group were (103.57±23.58), (20.54±4.21) and (68.29±14.59) pg/mL, respectively, which were lower than (245.29±15.36), (26.38±3.01) and (92.47±10.22) pg/mL, respectively, in the control group (P < 0.05). After treatment, OSAHS severity in the observation group was lower than that in the control group (P < 0.05). After treatment, the cognitive ability scored (23.61±3.29) in the observation group, which was higher than (20.87±1.16) in the control group, and sleep quality scored (0.38±0.08) in the observation group, which was lower than (1.42±0.22) in the control group (P < 0.05).

    Conclusion 

    CPAP combined with montelukast sodium and liraglutide can significantly reduce serum levels of 8-iso-PGF2α, IL-6 and CXCL13, improve sleep quality, relieve disease severity and promote recovery of cognitive function in T2DM patients with OSAHS.

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