Relationships of coagulation and fibrinolytic functions with patent foramen ovale complicated with cryptogenic stroke

Objective To analyze the correlations of coagulation and fibrinolytic functions with patent foramen ovale complicated with cryptogenic stroke.

Methods A total of 100 patients with patent foramen ovale and cryptogenic stroke from January 2020 to December 2022 were selected as observation group, and 100 patients with simple patent foramen ovale were selected as control group. Routine anticoagulant indicators and molecular markers of coagulation and fibrinolysis were detected in both groups; the multivariate Logistic regression model was used to analyze the correlations of coagulation and fibrinolytic function indicators with patent foramen ovale complicated with cryptogenic stroke; receiver operating characteristic (ROC) curve was used to analyze the efficiency of coagulation and fibrinolytic function indicators in predicting cryptogenic stroke inpatients with patent foramen ovale.

Results Levels of plasma D-dimer (D-D), fibrinogen lysate (FDP), thrombomodulin (TM), thrombin-antithrombin Ⅲ complex (TAT), plasminase-α2 plasminase inhibitor complex (PIC) and tissue plasminogen activator inhibitor-1 complex (t-PAIC) in the observation group were significantly higher than those in the control group (P < 0.05); the Multiple Logistic regressionanalysis showed that D-D, FDP, TM, TAT, PIC and t-PAIC were the independent predictors for cryptogenic stroke in patients with patent foramen ovale (P < 0.05); the ROC curve analysis showed the values of area under the curve (AUC) of D-D, FDP, TM, TAT, PIC and t-PAIC in predicting the onset of cryptogenic stroke in patients with patent foramen ovale were 0.665, 0.680, 0.835, 0.710, 0.680 and 0.752 respectively.

Conclusion Patients with patent foramen ovale and cryptogenic stroke have enhanced coagulation and fibrinolytic functions, and early monitoring of coagulation and fibrinolytic functions can help predict cryptogenic stroke.