Analysis in influencing factors of recurrence after endoscopic submucosal dissection for early esophageal cancer

JIANG Qiufu; WANG Rui; FENG Meiping; LIU Yang

doi:10.7619/jcmp.20232064

Journal of Clinical Medicine in Practice > 2023 > 27(19): 46-49, 55. > DOI: 10.7619/jcmp.20232064

JIANG Qiufu, WANG Rui, FENG Meiping, LIU Yang. Analysis in influencing factors of recurrence after endoscopic submucosal dissection for early esophageal cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(19): 46-49, 55. DOI: 10.7619/jcmp.20232064

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Analysis in influencing factors of recurrence after endoscopic submucosal dissection for early esophageal cancer

1.
the Seventh People's Hospital of Chengdu City in Sichuan Province, Chengdu, Sichuan, 610200
2.
West China Hospital of Sichuan University, Chengdu, Sichuan, 610200
3.
Sichuan Cancer Hospital, Chengdu, Sichuan, 610041

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Received Date: June 27, 2023
Revised Date: August 22, 2023
Available Online: October 18, 2023

Graphical Abstract

Abstract

Abstract

Objective
To analyze the risk factors of recurrence after endoscopic submucosal dissection (ESD) for early esophageal cancer by using Lasso-Logistic regression model.
Methods
A total of 300 patients with early esophageal cancer from January 2019 to October 2020 were selected as research objects, and all of them were treated with ESD. The recurrence rate at 12 months after surgery was recorded, and the risk factors of recurrence after ESD for early esophageal cancer were analyzed by using Lasso-Logistic regression model.
Results
At 12-month postoperative follow-up, 10 cases were lost due to poor follow-up awareness, and 5 cases were lost due to change of telephone number. A total of 28 patients experienced recurrence, with a recurrence rate of 9.82% (28/285), including 18 cases of mediastinal lymph node metastasis (64.29%) and 10 cases of distant metastasis (35.71%). In this study, we chose the optimal model at lambda. min=0.004, and a total of 3 variables (mean lesion diameter, degree of peri-traumatic mucosal defect, and pathological staging) entered the model; the fitting effect was assessed by using the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC), and the results indicated that the variables screened by the Lasso-Logistic regression model fitted and predicted relatively well.
Conclusion
ESD has a significant efficacy in the treatment of patients with early esophageal cancer, but there is a risk of recurrence after surgery, and mean lesion diameter, degree of peri-traumatic mucosal defect and pathological staging are the influencing factors.
- early esophageal cancer,
- endoscopic mucosal dissection,
- surgical effect,
- recurrence,
- influence factors

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References (21)

References

[1]	郑家垚, 林峥嵘, 许炎钦, 等. 浅表食管癌及癌前病变内镜黏膜下剥离术后水平切缘阳性高危因素分析及随访研究[J]. 中国内镜杂志, 2020, 26(8): 13-19. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ202008004.htm
[2]	薛冰艳, 田野, 朱国琴, 等. 内镜黏膜下剥离术治疗浅表食管癌368例临床分析[J]. 中华消化杂志, 2021, 41(6): 379-384.
[3]	Ishihara R, Arima M, Iizuka T, et al. Japan Gastroenterological Endoscopy Society Guidelines Committee of ESD/EMR for Esophageal Cancer. Endoscopic submucosal dissection/endoscopic mucosal resection guidelines for esophageal cancer[J]. Dig Endosc, 2020, 32(4): 452-493. doi: 10.1111/den.13654
[4]	高勇, 柏健鹰, 林辉, 等. 早期食管癌内镜黏膜下剥离术后食管狭窄的特征及影响因素探讨[J]. 中华消化内镜杂志, 2021, 38(9): 723-727. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202216003.htm
[5]	番敏, 张玟, 刘欢毅, 等. 磁锚定技术辅助内镜黏膜下剥离术治疗早期食管癌的实验研究[J]. 中华消化内镜杂志, 2021, 38(8): 650-653.
[6]	AADAM A A, ABE S. Endoscopic submucosal dissection for superficial esophageal cancer[J]. Dis Esophagus, 2018, 31(7): 346-347.
[7]	陈磊, 朱振, 王璐, 等. 内镜黏膜下隧道法剥离术治疗早期食管癌伴黏膜下层纤维化的临床观察[J]. 中华消化内镜杂志, 2020, 37(6): 429-434.
[8]	王苒霖, 包郁, 张真铭. 早期食管癌和癌前病变内镜黏膜下剥离术后食管狭窄的预防研究进展[J]. 肿瘤预防与治疗, 2021, 34(4): 365-372. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZF202104015.htm
[9]	曹彬. 全胸腔镜下食管癌切除术与常规手术的对比研究[J]. 中华生物医学工程杂志, 2020, 26(1): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ200402000.htm
[10]	NISHIZAWA T, YAHAGI N. Endoscopic mucosal resection and endoscopic submucosal dissection: technique and new directions[J]. Curr Opin Gastroenterol, 2017, 33(5): 315-319.
[11]	李宏伟, 赵呈华. 胸腹腔镜联合食管癌根治术对老年食管癌患者的近期疗效及安全性[J]. 癌症进展, 2020, 18(3): 297-299, 320. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ202003022.htm
[12]	李俊毅, 温越, 李渊, 等. 早期食管癌术后肿瘤复发的多因素分析[J]. 中国微创外科杂志, 2021, 21(8): 695-699. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWWK202108005.htm
[13]	沈文斌, 许金蕊, 李曙光, 等. 食管癌术后复发患者放化疗疗效及预后分析[J]. 中华放射医学与防护杂志, 2021, 41(9): 678-684.
[14]	胡嘉庆, 林晓露, 郑家垚, 等. 布地奈德凝胶预防食管内镜黏膜下剥离术后大面积狭窄的价值[J]. 中华消化内镜杂志, 2020, 37(7): 471-475.
[15]	BRINKMANN S, CHANG D H, KUHR K, et al. Stenosis of the celiac trunk is associated with anastomotic leak after Ivor-Lewis esophagectomy[J]. Dis Esophagus, 2019, 32(7): doy107.
[16]	时强, 周平红, 钟芸诗, 等. 食管胃同时性双原发早期癌或癌前病变内镜黏膜下剥离术疗效分析[J]. 中华消化内镜杂志, 2018, 35(6): 410-414.
[17]	王海燕, 屈丽娜, 邓水苗, 等. 内镜黏膜下剥离术术后食管狭窄的预防新进展[J]. 兰州大学学报: 医学版, 2020, 46(3): 54-62. https://www.cnki.com.cn/Article/CJFDTOTAL-LZYX202003010.htm
[18]	平付敏, 崔星亮, 郭晓会, 等. 经内镜黏膜下剥离术治疗合并心血管疾病食管早癌及癌前病变患者的预后与影响因素分析[J]. 国际心血管病杂志, 2017, 44(S1): 13-14.
[19]	金树, 詹翔, 张道权, 等. 内镜下多环黏膜套扎切除术治疗食管癌前病变和食管早癌的疗效及安全性分析[J]. 中国内镜杂志, 2018, 24(12): 33-37. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ201812007.htm
[20]	刘姚江, 林辉, 樊超强, 等. 内镜黏膜下剥离术治疗食管早癌及癌前病变384例临床分析[J]. 第三军医大学学报, 2018, 40(11): 1022-1027. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201811014.htm
[21]	姜红建, 韩文良, 李小环, 等. 内镜黏膜下剥离术治疗早期食管癌及食管癌前病变探讨[J]. 国际医药卫生导报, 2019, 25(14): 2251-2253. https://www.cnki.com.cn/Article/CJFDTOTAL-LCLZ202307015.htm

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Analysis in influencing factors of recurrence after endoscopic submucosal dissection for early esophageal cancer