Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm

CONG Xiaoyu; DA Yingfen; WANG Cheng; LIANG Xinfeng; CHEN Min; YUAN Jie

doi:10.7619/jcmp.20232343

Journal of Clinical Medicine in Practice > 2023 > 27(24): 20-25. > DOI: 10.7619/jcmp.20232343

CONG Xiaoyu, DA Yingfen, WANG Cheng, LIANG Xinfeng, CHEN Min, YUAN Jie. Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm[J]. Journal of Clinical Medicine in Practice, 2023, 27(24): 20-25. DOI: 10.7619/jcmp.20232343

Citation:

PDF (2983 KB)

Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm

1.
Department of Ultrasound, Huangpu Branch of the Ninth People's Hospital Affiliated to School of Medicine of Shanghai Jiaotong University, Shanghai, 200011
2.
Department of Breast Surgery, Huangpu Branch of the Ninth People's Hospital Affiliated to School of Medicine of Shanghai Jiaotong University, Shanghai, 200011

More Information

Received Date: July 23, 2023
Revised Date: September 19, 2023
Available Online: January 04, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the clinicopathological and ultrasonic characteristics of different molecular types of breast cancer with maximum diameter ≤2 cm, and analyze the diagnostic value of conventional ultrasound.
Methods
A total of 174 breast cancer patients with diameter ≤2 cm were selected as the study objects. According to the immunohistochemical results, they were divided into LA group (Luminal A, n=46), LB group (Luminal B, n=71), HER-2 group (HER-2 overexpression type, n=11) and triple-negative group (triple-negative, n=46). The clinicopathology, ultrasonic characteristics and the accuracy of conventional ultrasonic diagnosis were analyzed.
Results
There were significant differences in breast cancer size, pathological grade and pathological type among four groups (P < 0.05). Among the ultrasonic characteristics, there were statistically significant differences in shape, edge, aspect ratio, calcification and rear echo among the four groups (P < 0.05). Breast Imaging Reporting and Data System (BI-RADS) grading and accuracy of conventional ultrasound diagnosis among the four groups showed statistically significant differences (P < 0.05).
Conclusion
The clinicopathological features, ultrasound features and BI-RADS grading of different molecular types of breast cancer with maximum diameter ≤2 cm are different. Routine ultrasound has certain diagnostic value, which can provide important reference for molecular classification diagnosis, individualized treatment and prognosis evaluation of early breast cancer.
- breast cancer,
- molecular classification,
- ultrasound examination,
- accuracy rate

FullText(HTML)

References (23)

References

[1]	笪霞, 纪璟, 朱春花, 等. 乳腺癌患者保乳术联合腔镜腋窝淋巴结清扫术的临床研究[J]. 实用临床医药杂志, 2022, 26(8): 49-53. doi: 10.7619/jcmp.20214131
[2]	盛常睿, 张玉, 陈赛君, 等. 早期乳腺癌患者乳腺超声特点及误诊和漏诊影响因素探讨[J]. 中国超声医学杂志, 2020, 36(6): 495-498. doi: 10.3969/j.issn.1002-0101.2020.06.005
[3]	黄建玲, 林丹丹, 冯楚霞, 等. 超声剪切波弹性成像联合BI-RADS-US对乳腺小肿块的各向异性良恶性的评估价值[J]. 中国超声医学杂志, 2022, 38(10): 1101-1104.
[4]	胡丹婷, 郑晓静, 尤超, 等. 数字乳腺摄影联合超声在小乳腺癌诊断中的应用[J]. 中国超声医学杂志, 2022, 38(3): 267-270.
[5]	徐可佩, 岑欣怡, 黄可玲, 等. MRI影像组学联合分子分型预测乳腺癌复发的研究进展[J]. 中国医学计算机成像杂志, 2023, 29(3): 330-334.
[6]	VUONG D, SIMPSON P T, GREEN B, et al. Molecular classification of breast cancer[J]. Virchows Arch, 2014, 465(1): 1-14. doi: 10.1007/s00428-014-1593-7
[7]	李佳伟, 方舟, 周瑾, 等. 浸润性三阴性乳腺癌超声影像组学特征与肿瘤生物学特性的关系研究[J]. 中华超声影像学杂志, 2019, 28(2): 138-144.
[8]	张宇, 刘梁生, 马文娟, 等. 早期肿块型乳腺浸润性导管癌超声征象与分子分型的相关性研究[J]. 天津医药, 2022, 50(8): 853-858.
[9]	ZHENG X, LI F, XUAN Z D, et al. Combination of shear wave elastography and BI-RADS in identification of solid breast masses[J]. BMC Med Imaging, 2021, 21(1): 183. doi: 10.1186/s12880-021-00702-4
[10]	American College of Radiology. Breast imaging reporting and data system (BI-RADS) ultrasound[S]. Reston, Va: American College of Radiology, 2013.
[11]	CURIGLIANO G, BURSTEIN H J, P WINER E, et al. De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017[J]. Ann Oncol, 2019, 30(7): 1181. doi: 10.1093/annonc/mdy537
[12]	ŁUKASIEWICZ S, CZECZELEWSKI M, FORMA A, et al. Breast cancer-epidemiology, risk factors, classification, prognostic markers, and current treatment strategies-an updated review[J]. Cancers, 2021, 13(17): 4287. doi: 10.3390/cancers13174287
[13]	FORSARE C, BAK M, FALCK A K, et al. Non-linear transformations of age at diagnosis, tumor size, and number of positive lymph nodes in prediction of clinical outcome in breast cancer[J]. BMC Cancer, 2018, 18(1): 1226. doi: 10.1186/s12885-018-5123-x
[14]	丁通, 孔祥海, 杨迎青. 4种分子分型乳腺癌的超声特征分析[J]. 中国现代医学杂志, 2021, 31(5): 24-28.
[15]	吕琪, 吴军刚, 贾春梅, 等. 年轻女性乳腺浸润性导管癌及其不同分子亚型的超声声像图特征分析[J]. 中国全科医学, 2020, 23(3): 358-362.
[16]	何莹, 王敏芳, 郑莎莎, 等. 乳腺癌微钙化与HER2、ER、PR、Ki67的相关性分析[J]. 中国超声医学杂志, 2022, 38(6): 633-636.
[17]	FENG M Y, GRICE D M, FADDY H M, et al. Store-independent activation of Orai1 by SPCA2 in mammary tumors[J]. Cell, 2010, 143(1): 84-98. doi: 10.1016/j.cell.2010.08.040
[18]	高军喜, 马方婧, 杨磊, 等. 不同分子亚型乳腺癌超声造影特征及定量参数对比研究[J]. 中国临床医学影像杂志, 2019, 30(4): 261-266.
[19]	SONG K H, TRUDEAU T, KAR A, et al. Ultrasound-mediated delivery of siESE complexed with microbubbles attenuates HER2+/- cell line proliferation and tumor growth in rodent models of breast cancer[J]. Nanotheranostics, 2019, 3(2): 212-222. doi: 10.7150/ntno.31827
[20]	ZHANG W X, XU C, LI R, et al. Correlation analysis between ultrasonography and mammography with other risk factors related to breast cancer[J]. Oncol Lett, 2019, 17(6): 5511-5516.
[21]	徐丽秀, 李佳妮, 孙继红, 等. p90核糖体S6激酶2: 治疗三阴性乳腺癌的潜在靶标[J]. 药学进展, 2022, 46(11): 858-866.
[22]	张婷, 唐志强. 舒尼替尼联合卡培他滨治疗三阴性乳腺癌对血管生成因子和凋亡因子的影响[J]. 检验医学与临床, 2023, 20(2): 232-236.
[23]	赵枫, 肖际东, 文欢, 等. 计算机辅助诊断技术可提高肿块最大径≤10 mm早期乳腺癌的超声诊断[J]. 分子影像学杂志, 2021, 44(2): 226-231.

[1]	QIN Aiping, YANG Yan, QI Tingyue. Ultrasonic characteristics and prognostic analysis of different molecular subtypes of invasive breast cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(24): 26-29, 36. DOI: 10.7619/jcmp.20232160
[2]	ZHANG Manqi, ZHA Hailing, LIU Xinpei, WANG Jue, CHEN Rui, LI Cuiying. Accuracy of ultrasonic evaluation of neoadjuvant chemotherapy for breast cancer and analysis of influencing factors[J]. Journal of Clinical Medicine in Practice, 2022, 26(13): 45-49, 54. DOI: 10.7619/jcmp.20220387
[3]	GONG Haiyan, WANG Hui, DENG Jing, ZHA Hailing, ZHOU Wenbin, LI Cuiying. Analysis in contrast-enhanced ultrasound features of breast cancer for different Luminal types[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 19-23. DOI: 10.7619/jcmp.20210737
[4]	LI Guangquan, ZHONG Peiying. Diagnosis accuracy of acute myocardial infarction in patients with renal injury using high-sensitivity troponin T[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 85-88. DOI: 10.7619/jcmp.20211396
[5]	DENG Mingcai, CHEN Hexing, XIONG Ying. Value of transabdominal and transvaginal ultrasound in diagnosing ectopic pregnancy[J]. Journal of Clinical Medicine in Practice, 2020, 24(9): 90-93. DOI: 10.7619/jcmp.202009026
[6]	WANG Dan, CHEN Gengwu. Accuracy of morphology of gastric mucosa by gastroscopy in the judgment of Helicobacter pylori infection[J]. Journal of Clinical Medicine in Practice, 2020, 24(4): 87-89. DOI: 10.7619/jcmp.202004022
[7]	XU Guoxin. Accuracy rate of intraoperative frozen section in diagnosis of papillary thyroid microcarcinoma and its influencing factors[J]. Journal of Clinical Medicine in Practice, 2020, 24(4): 50-53. DOI: 10.7619/jcmp.202004012
[8]	HAN Pihua, SONG Zhangjun, YANG Xiaomin, WANG Huxia, HE Sai, FAN Yongguo, HOU Yanni. Value of ultrasonography in the diagnosis of benign and malignant axillary lymph nodes in breast cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(16): 93-96. DOI: 10.7619/jcmp.201916025
[9]	LIU Luqin, LI Jie. Effect of blood culture combined with serum detection of PCT and CRP on the diagnostic accuracy of patients with severe puerperal infection[J]. Journal of Clinical Medicine in Practice, 2018, (15): 116-117,120. DOI: 10.7619/jcmp.201815033
[10]	LUO Huafu, ZHANG Xianlin, CHEN Jianxin. Effects of different delay time on examination results of patients with suspected cervical cancer after injection of contrast agents[J]. Journal of Clinical Medicine in Practice, 2017, (13): 80-82. DOI: 10.7619/jcmp.201713021

Cited By

Get Citation

PDF

XML

Article views (154) PDF downloads (9)

Turn off MathJax

Article Contents

Abstract

References

Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm

Abstract

References

Related Articles

Catalog

Ultrasonic characteristics and diagnostic value of different molecular types of breast cancer with maximum diameter within 2 cm

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content