| Citation: |
PENG Guolin, ZHANG Yurong, ZHANG Rui, JIANG Xinting, LI Juan. Application value of prognostic nutritional index and neutrophil-to-lymphocyte ratio in predicting prognosis of patients with osteosarcoma[J]. Journal of Clinical Medicine in Practice, 2023, 27(21): 42-46, 51. DOI: 10.7619/jcmp.20232350
|
To explore the value of prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) in predicting the prognosis of patients with osteosarcoma.
From 2000 to 2018, medical records of 92 patients with osteosarcoma were collected from two comprehensive hospitals in Yibin city and clinical outcomes of patients were followed up. Receiver operating characteristic (ROC) curve was used to analyze the cut-off values of PNI and NLR for prognosis prediction; the Kaplan-Meier method was used to draw survival curve; the Log-rank test and Cox regression model were used to analyze the influencing factors of prognosis.
The average follow-up time of 92 patients was 58 months, with an average survival time of 50 (23, 61) months; during the follow-up period, 47 patients (51.09%) died, with a 5-year survival rate of 51.09%. The areas under the curve of ROC curves for PNI and NLR were 0.957 and 0.788 respectively, with the optimal cut-off values of 46.35 and 2.10. Cox regression model showed that metastasis at diagnosis and PNI < 46.35 were the risk factors for prognosis, with hazard ratio and its 95% confidence interval[HR (95%CI) of4.361(2.021 to 9.410) and 15.361 (5.797 to 46.118) respectively; NLR < 2.10 was a protective factor for prognosis, with HR (95%CI) of0.781 (0.631 to 0.967). The 5-year survival rates of patients with and without metastasis at diagnosis were 10.26% and 81.13% respectively; the 5-year survival rates of patients with PNI < 46.35 and ≥46.35 were 11.11% and 89.36% respectively; the 5-year survival rates of patients with NLR < 2.10 and ≥2.10 were 87.10% and 32.79% respectively.
PNI, NLR and status of metastasis at diagnosis are associated with prognosis of patients with osteosarcoma.
| [1] |
SADYKOVA L R, NTEKIM A I, MUYANGWA-SEMENOVA M, et al. Epidemiology and risk factors of osteosarcoma[J]. Cancer Invest, 2020, 38(5): 259-269. doi: 10.1080/07357907.2020.1768401
|
| [2] |
杨勇, 陈江涛, 楚慧慧, 等. 新疆地区维、汉、哈族骨肉瘤患者流行病学特征分析[J]. 实用骨科杂志, 2018, 24(2): 130-133. doi: 10.13795/j.cnki.sgkz.2018.02.009
|
| [3] |
王利娜. 饮食因素与青少年下肢骨肉瘤关系的病例对照研究[D]. 北京: 北京中医药大学, 2019.
|
| [4] |
PELED Y, LEVIN D, SHIRAN S, et al. Prevalence and management of methotrexate-induced neurotoxicity in pediatric patients with osteosarcoma: a single-center experience[J]. Int J Clin Oncol, 2022, 27(8): 1372-1378. doi: 10.1007/s10147-022-02184-y
|
| [5] |
刘懿天, 庄然, 丁勇. NEDD4L作为骨肉瘤预后标志物的生物信息学研究[J]. 空军军医大学学报, 2023, 44(1): 74-81. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY202301012.htm
|
| [6] |
KHANDIA R, MUNJAL A. Interplay between inflammation and cancer[J]. Adv Protein Chem Struct Biol, 2020, 119: 199-245.
|
| [7] |
DING P A, GUO H H, SUN C Y, et al. Combined systemic immune-inflammatory index (SⅡ) and prognostic nutritional index (PNI) predicts chemotherapy response and prognosis in locally advanced gastric cancer patients receiving neoadjuvant chemotherapy with PD-1 antibody sintilimab and XELOX: a prospective study[J]. BMC Gastroenterol, 2022, 22(1): 121. doi: 10.1186/s12876-022-02199-9
|
| [8] |
FANG K H, CHANG S W, LEE Y C, et al. Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer[J]. Oral Dis, 2022, 28(7): 1816-1830. doi: 10.1111/odi.13840
|
| [9] |
叶尔哈那提·胡杜斯, 阿尔恒别克·吐汗拜, 艾克拜尔·尤努斯. NLR、LMR和PLR与骨肉瘤预后的关系[J]. 肿瘤防治研究, 2021, 48(4): 381-386. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLFY202104011.htm
|
| [10] |
ABE A, KURITA K, HAYASHI H, et al. Correlation between prognostic nutritional index and occlusal status in gastric cancer[J]. Oral Dis, 2020, 26(2): 465-472. doi: 10.1111/odi.13242
|
| [11] |
ZHAO X, WU Q R, GONG X Q, et al. Osteosarcoma: a review of current and future therapeutic approaches[J]. Biomed Eng Online, 2021, 20(1): 24. doi: 10.1186/s12938-021-00860-0
|
| [12] |
YANG Q K, SU Y N, WANG W, et al. CONUT score or/and peripheral blood CD4+/CD8+ ratio-based web dynamic nomograms to predict the individualized survival of patients with advanced osteosarcoma[J]. Cancer Manag Res, 2020, 12: 4193-4208. doi: 10.2147/CMAR.S251814
|
| [13] |
SINGH N, BABY D, RAJGURU J, et al. Inflammation and cancer[J]. Ann Afr Med, 2019, 18(3): 121. doi: 10.4103/aam.aam_56_18
|
| [14] |
闻丹忆. 体外诊断的开发前沿与应用进展[J]. 药学进展, 2023, 47(6): 401-403. https://www.cnki.com.cn/Article/CJFDTOTAL-YXJZ202306008.htm
|
| [15] |
WANG D, HU X, XIAO L, et al. Prognostic nutritional index and systemic immune-inflammation index predict the prognosis of patients with HCC[J]. J Gastrointest Surg, 2021, 25(2): 421-427. doi: 10.1007/s11605-019-04492-7
|
| [16] |
CUPP M A, CARIOLOU M, TZOULAKI I, et al. Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies[J]. BMC Med, 2020, 18(1): 360. doi: 10.1186/s12916-020-01817-1
|
| [17] |
YAMAMOTO T, KAWADA K, OBAMA K. Inflammation-related biomarkers for the prediction of prognosis in colorectal cancer patients[J]. Int J Mol Sci, 2021, 22(15): 8002. doi: 10.3390/ijms22158002
|
| [18] |
MA C, YU R H, LI J H, et al. Preoperative prognostic nutritional index and systemic immune-inflammation index predict survival outcomes in osteosarcoma: a comparison between young and elderly patients[J]. J Surg Oncol, 2021, 125: 754-765.
|
| [19] |
TANG H J, LIU D H, LU J L, et al. Significance of the neutrophil-to-lymphocyte ratio in predicting the response to neoadjuvant chemotherapy in extremity osteosarcoma: a multicentre retrospective study[J]. BMC Cancer, 2022, 22(1): 33. doi: 10.1186/s12885-021-09130-7
|
| [20] |
LIU J J, LI S, ZHANG S, et al. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab[J]. J Clin Lab Anal, 2019, 33(8): e22964. doi: 10.1002/jcla.22964
|
| [21] |
CHEN H J, SONG S H, ZHANG L Q, et al. Preoperative platelet-lymphocyte ratio predicts recurrence of laryngeal squamous cell carcinoma[J]. Future Oncol, 2020, 16(6): 209-217.
|
| [22] |
SHIMPEI O, MICHIO I, YOSHIKO B, et al. Stage Ⅱ colon cancer staging using the number of retrieved lymph nodes may be superior to current TNM staging for prognosis stratification: the Japanese study group for postoperative follow up of colorectal cancer[J]. Int J Colorectal Dis, 2021, 36(10): 1-10.
|
| [23] |
WANG N, CHEN Y, WU J. CCT6A is associated with CDC20, Enneking stage and prognosis in osteosarcoma, and its knockdown suppresses osteosarcoma cell viability and invasion[J]. Oncol Lett, 2023, 25(5): 201.
|
| [24] |
杨万波, 施俊, 何晶, 等. 术前中性粒细胞淋巴细胞、血小板淋巴细胞和淋巴细胞单核细胞比值对骨肉瘤患者预后的影响[J]. 中华实验外科杂志, 2019, 36(11): 1963-1965. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWK202011007.htm
|
| [25] |
YANG Y H, ZHOU C, MA X L. Use of nomogram on nutritional assessment indicators to predict clinical outcomes in patients undergoing surgical resection for high grade osteosarcoma[J]. Nutr Cancer, 2022, 74(10): 3564-3573.
|
| [26] |
HUANG X, HU H Z, ZHANG W Y, et al. Prognostic value of prognostic nutritional index and systemic immune inflammation index in patients with osteosarcoma[J]. J Cell Physiol, 2019, 234(10): 18408-18414.
|
© 2020 《实用临床医药杂志》编辑部
Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807
Supported by:
Beijing Renhe Information Technology Co., Ltd.
苏公网安备 32100302010246号
DownLoad: