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ZHAO Yun, CUI Jian. Research on the risk factors of anastomotic fistula after esophageal cancer surgery[J]. Journal of Clinical Medicine in Practice, 2024, 28(1): 37-40. DOI: 10.7619/jcmp.20232650
Citation: ZHAO Yun, CUI Jian. Research on the risk factors of anastomotic fistula after esophageal cancer surgery[J]. Journal of Clinical Medicine in Practice, 2024, 28(1): 37-40. DOI: 10.7619/jcmp.20232650
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Research on the risk factors of anastomotic fistula after esophageal cancer surgery

  • Department of Thoracic Surgery, Beijing Chuiyangliu Hospital Affiliated to Tsinghua University, Beijing, 100022

More Information
  • Received Date: August 19, 2023
  • Revised Date: October 12, 2023
  • Available Online: January 22, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the risk factors of anastomotic fistula after esophageal cancer surgery.

    Methods 

    The clinical data of 107 patients with esophageal cancer surgery were retrospectively analyzed, among whom 21 patients with anastomotic fistula after surgery were included in observation group, and 86 patients without anastomotic fistula after surgery were included in control group. The risk factors of anastomotic fistula after esophageal cancer surgery were identified by univariate analysis and multivariate Logistic regression analysis.

    Results 

    Univariate analysis showed that age, hypoproteinemia, history of diabetes, preoperative neoadjuvant therapy, and anastomotic site were associated with anastomotic fistula after esophageal cancer surgery (P < 0.05); multivariate Logistic regression analysis showed that preoperative neoadjuvant therapy was an independent risk factor for postoperative anastomotic fistula in patients with esophageal cancer (OR=5.392; 95%CI, 1.335 to 30.382; P=0.020).

    Conclusion 

    Preoperative neoadjuvant therapy is an independent risk factor for postoperative anastomotic fistula in patients with esophageal cancer. For patients with preoperative comorbid diseases, especially diabetes and hypoproteinemia, adequate preoperative preparation should be made.

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    • References (26)
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