Advance Search
LI Yuanyuan, HAO Jian. Research progress of anti-neutrophil cytoplasmic antibody associated vasculitis[J]. Journal of Clinical Medicine in Practice, 2024, 28(7): 143-148. DOI: 10.7619/jcmp.20233407
Citation: LI Yuanyuan, HAO Jian. Research progress of anti-neutrophil cytoplasmic antibody associated vasculitis[J]. Journal of Clinical Medicine in Practice, 2024, 28(7): 143-148. DOI: 10.7619/jcmp.20233407
shu

Research progress of anti-neutrophil cytoplasmic antibody associated vasculitis

  • 1.

    Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050

  • 2.

    Department of Nephrology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050

More Information
  • Received Date: October 26, 2023
  • Revised Date: December 25, 2023
  • Available Online: April 21, 2024
    Graphical Abstract
    • Abstract

  • Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a class of autoimmune diseases characterized by inflammation of the small vessel wall and fibrinoid necrosis that can involve multiple systems throughout the body. AAV in the Asian region is mainly characterized by microscopic polyangitis (MPA), which most commonly affects the kidneys and lungs. In recent years, it has been discovered that complement such as C5a plays an important role in the pathogenesis of AAV through alternative pathways. Therefore, understanding the relationship between AAV complement and coagulation processes is beneficial for identifying therapeutic targets from the perspective of pathogenesis. This review summerized the research progress on the changes in coagulation and fibrinolysis systems and their interactions with the complement system in the pathogenesis of AAV.

    • FullText(HTML)
    • References (41)
  • [1]
    JENNETTE J C, FALK R J. Small-vessel vasculitis[J]. N Engl J Med, 1997, 337(21): 1512-1523. doi: 10.1056/NEJM199711203372106
    [2]
    SEGELMARK M, WIESLANDER J. IgG subclasses of antineutrophil cytoplasm autoantibodies (ANCA)[J]. Nephrol Dial Transplant, 1993, 8(8): 696-702. doi: 10.1093/ndt/8.8.696
    [3]
    JENNETTE J C, FALK R J, BACON P A, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides[J]. Arthritis Rheum, 2013, 65(1): 1-11. doi: 10.1002/art.37715
    [4]
    XIN G, ZHAO M H, WANG H Y. Detection rate and antigenic specificities of antineutrophil cytoplasmic antibodies in Chinese patients with clinically suspected vasculitis[J]. Clin Diagn Lab Immunol, 2004, 11(3): 559-562.
    [5]
    FARRAH T E, MELVILLE V, CZOPEK A, et al. Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis[J]. Kidney Int, 2022, 102(5): 1115-1126. doi: 10.1016/j.kint.2022.07.026
    [6]
    GRIMSEY N J, TREJO J. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin[J]. Curr Opin Hematol, 2016, 23(3): 274-279. doi: 10.1097/MOH.0000000000000232
    [7]
    SUN X J, CHEN M, ZHAO M H. Thrombin contributes to anti-myeloperoxidase antibody positive IgG-mediated glomerular endothelial cells activation through SphK1-S1P-S1PR3 signaling[J]. Front Immunol, 2019, 10: 237. doi: 10.3389/fimmu.2019.00237
    [8]
    TAKEYA H, GABAZZA E C, AOKI S, et al. Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells[J]. Blood, 2003, 102(5): 1693-1700. doi: 10.1182/blood-2002-11-3607
    [9]
    SALMELA A, EKSTRAND A, JOUTSI-KORHONEN L, et al. Activation of endothelium, coagulation and fibrinolysis is enhanced and associates with renal anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Nephrol Dial Transplant, 2015, 30: i53-59. doi: 10.1093/ndt/gfu379
    [10]
    GO E, AESCHLIMANN F A, LU H, et al. Von Willebrand factor antigen as a marker of disease activity in childhood-onset antineutrophil cytoplasmic antibody-associated vasculitis[J]. Rheumatology, 2023: kead600. doi: 10.1093/rheumatology/kead600
    [11]
    MA T T, HUANG Y M, WANG C, et al. Coagulation and fibrinolysis index profile in patients with ANCA-associated vasculitis[J]. PLoS One, 2014, 9(5): e97843. doi: 10.1371/journal.pone.0097843
    [12]
    CHEN S S, LUO H J, LI H, et al. Elevated plasma FXII is associated with disease activity in ANCA-associated vasculitis: A Retrospective Cross-Sectional Study in Western China[J]. Int Immunopharmacol, 2023, 125(Pt A): 111067.
    [13]
    MIAO D, LI D Y, CHEN M, et al. Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway[J]. Arthritis Res Ther, 2017, 19(1): 252. doi: 10.1186/s13075-017-1458-y
    [14]
    MATSUMOTO K, YASUOKA H, YOSHIMOTO K, et al. Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis[J]. Sci Rep, 2021, 11(1): 222. doi: 10.1038/s41598-020-80685-4
    [15]
    VOGEL S, BODENSTEIN R, CHEN Q W, et al. Platelet-derived HMGB1 is a critical mediator of thrombosis[J]. J Clin Investig, 2015, 125(12): 4638-4654. doi: 10.1172/JCI81660
    [16]
    BERDEN A E, NOLAN S L, MORRIS H L, et al. Anti-plasminogen antibodies compromise fibrinolysis and associate with renal histology in ANCA-associated vasculitis[J]. J Am Soc Nephrol, 2010, 21(12): 2169-2179. doi: 10.1681/ASN.2010030274
    [17]
    HILHORST M, WINCKERS K, WILDE B, et al. Patients with antineutrophil cytoplasmic antibodies associated vasculitis in remission are hypercoagulable[J]. J Rheumatol, 2013, 40(12): 2042-2046. doi: 10.3899/jrheum.130200
    [18]
    BOROWIEC A, DABROWSKI R, KOWALIK I, et al. Elevated levels of d-dimer are associated with inflammation and disease activity rather than risk of venous thromboembolism in patients with granulomatosis with polyangiitis in long term observation[J]. Adv Med Sci, 2020, 65(1): 97-101. doi: 10.1016/j.advms.2019.12.007
    [19]
    LIDINGTON E A, HASKARD D O, MASON J C. Induction of decay-accelerating factor by thrombin through a protease-activated receptor 1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury[J]. Blood, 2000, 96(8): 2784-2792. doi: 10.1182/blood.V96.8.2784
    [20]
    HUBER-LANG M, SARMA J V, ZETOUNE F S, et al. Generation of C5a in the absence of C3: a new complement activation pathway[J]. Nat Med, 2006, 12(6): 682-687. doi: 10.1038/nm1419
    [21]
    CLARK A, WEYMANN A, HARTMAN E, et al. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration[J]. Mol Immunol, 2008, 45(11): 3125-3132. doi: 10.1016/j.molimm.2008.03.008
    [22]
    AMARA U, FLIERL M A, RITTIRSCH D, et al. Molecular intercommunication between the complement and coagulation systems[J]. J Immunol, 2010, 185(9): 5628-5636. doi: 10.4049/jimmunol.0903678
    [23]
    FOLEY J H, WALTON B L, ALEMAN M M, et al. Complement activation in arterial and venous thrombosis is mediated by plasmin[J]. EBioMedicine, 2016, 5: 175-182. doi: 10.1016/j.ebiom.2016.02.011
    [24]
    AL-HUSSAIN T, HUSSEIN M H, CONCA W, et al. Pathophysiology of ANCA-associated vasculitis[J]. Adv Anat Pathol, 2017, 24(4): 226-234. doi: 10.1097/PAP.0000000000000154
    [25]
    IKEDA K, NAGASAWA K, HORIUCHI T, et al. C5a induces tissue factor activity on endothelial cells[J]. Thromb Haemost, 1997, 77(2): 394-398. doi: 10.1055/s-0038-1655974
    [26]
    RITIS K, DOUMAS M, MASTELLOS D, et al. A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways[J]. J Immunol, 2006, 177(7): 4794-4802. doi: 10.4049/jimmunol.177.7.4794
    [27]
    HUANG Y M, WANG H, WANG C, et al. Promotion of hypercoagulability in antineutrophil cytoplasmic antibody-associated vasculitis by C5a-induced tissue factor-expressing microparticles and neutrophil extracellular traps[J]. Arthritis Rheumatol, 2015, 67(10): 2780-2790. doi: 10.1002/art.39239
    [28]
    RAO A N, KAZZAZ N M, KNIGHT J S. Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases[J]. World J Cardiol, 2015, 7(12): 829-842. doi: 10.4330/wjc.v7.i12.829
    [29]
    WANG H, WANG C, ZHAO M H, et al. Neutrophil extracellular traps can activate alternative complement pathways[J]. Clin Exp Immunol, 2015, 181(3): 518-527. doi: 10.1111/cei.12654
    [30]
    WU K L, LIANG Q H, DING N, et al. Sphingosine-1-phosphate in anti-neutrophil cytoplasmic antibody-associated vasculitis: coagulation-related clinical indicators and complications[J]. Biosci Rep, 2020, 40(10): BSR20200157. doi: 10.1042/BSR20200157
    [31]
    RITIS K, DOUMAS M, MASTELLOS D, et al. A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways[J]. J Immunol, 2006, 177(7): 4794-4802. doi: 10.4049/jimmunol.177.7.4794
    [32]
    SUN X J, CHEN M, ZHAO M H. Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG[J]. J Cell Mol Med, 2018, 22(3): 1769-1777. doi: 10.1111/jcmm.13458
    [33]
    HAO J, LV T G, WANG C, et al. Macrophage migration inhibitory factor contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation[J]. Hum Immunol, 2016, 77(12): 1209-1214. doi: 10.1016/j.humimm.2016.08.006
    [34]
    HAO J, LV T G, XU L P, et al. Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils[J]. BMC Immunol, 2019, 20(1): 22. doi: 10.1186/s12865-019-0306-z
    [35]
    KLAPA S, MÜLLER A, KOCH A, et al. Low concentrations of C5a complement receptor antibodies are linked to disease activity and relapse in ANCA-associated vasculitis[J]. Arthritis Rheumatol. 2022 Nov 21.
    [36]
    LEE A. Avacopan: first approval[J]. Drugs, 2022, 82(1): 79-85. doi: 10.1007/s40265-021-01643-6
    [37]
    CHEN S F, WANG F M, LI Z Y, et al. Erratum to: plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis[J]. Arthritis Res Ther, 2017, 19(1): 82. doi: 10.1186/s13075-017-1298-9
    [38]
    CHEN S F, WANG F M, LI Z Y, et al. Complement factor H inhibits anti-neutrophil cytoplasmic autoantibody-induced neutrophil activation by interacting with neutrophils[J]. Front Immunol, 2018, 9: 559. doi: 10.3389/fimmu.2018.00559
    [39]
    PUY C, PANG J, REITSMA S E, et al. Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H[J]. J Immunol, 2021, 206(8): 1784-1792. doi: 10.4049/jimmunol.2000398
    [40]
    HEAL S L, HARDY L J, WILSON C L, et al. Novel interaction of properdin and coagulation factor XI: Crosstalk between complement and coagulation[J]. Res Pract Thromb Haemost, 2022, 6(4): e12715. doi: 10.1002/rth2.12715
    [41]
    FREELEY S J, POPAT R J, PARMAR K, et al. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5[J]. J Pathol, 2016, 240(1): 61-71. doi: 10.1002/path.4754
    • Related Articles

  • Related Articles

    [1]LIU Guixiang, AN Jinmei, HOU Jichong, SONG Nuan, ZHAO Yuexia. Effects of painting combined with drug intervention on mental states, compliance and quality of life in patients with anxiety disorder[J]. Journal of Clinical Medicine in Practice, 2023, 27(22): 81-85. DOI: 10.7619/jcmp.20230109
    [2]LIN Yan, ZHOU Ping, LI Yanzhen, LI Shiting. Effect of preoperative anxiety and depression and sleep qualityon sequelae of Bell's palsy and its intervention strategy[J]. Journal of Clinical Medicine in Practice, 2021, 25(7): 30-33. DOI: 10.7619/jcmp.20201495
    [3]HUANG Chunyu, QIAN Xiangyun, SU Lingyan, CUI Hongyan, JI Yanhua, ZHOU Guo. Study on Yoga healing therapy on sleep quality in senile patients with hypertension[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 105-107. DOI: 10.7619/jcmp.201924033
    [4]LIU Min, LUO Caifeng. Investigation and analysis of mental health status and sleepquality in Helicobacter pylori positive infection patients[J]. Journal of Clinical Medicine in Practice, 2019, 23(11): 27-31. DOI: 10.7619/jcmp.201911008
    [5]PAN Jiani. Effect of psychological nursing on mental state and quality of life in patients with cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2018, (12): 15-18. DOI: 10.7619/jcmp.201812005
    [6]CHEN Rende. The effect of duloxetine on sleeping quality of elderly female patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (Z1): 159-160.
    [7]GAO Lini. Effect of nursing intervention on quality of sleep and quality of life in perimenopausal women with insomnia[J]. Journal of Clinical Medicine in Practice, 2015, (18): 78-80. DOI: 10.7619/jcmp.201518025
    [8]XU Yuhua. Influence of prenatal knowledge training on postpartum mental state and quality of life in delivery women with cesarean section[J]. Journal of Clinical Medicine in Practice, 2014, (10): 74-76. DOI: 10.7619/jcmp.201410025
    [9]ZHOU Chunhua. Effect of nursing intervention on postpartum hemorrhage and sleep quality of primiparae with caesarean section[J]. Journal of Clinical Medicine in Practice, 2014, (8): 110-112. DOI: 10.7619/jcmp.201408041
    [10]LU Xuemei. Effect of KAP nursing mode in improving sleep quality and psychological state of patients with colorectal cancer during perioperative period[J]. Journal of Clinical Medicine in Practice, 2013, (16): 145-146,152. DOI: 10.7619/jcmp.201316056

  • Cited by

    Periodical cited type(17)

    1. 郑雅群. 坚强概念健康宣教联合全程化优质服务对肺结核大咯血患者服药依从性的影响. 基层医学论坛. 2024(24): 131-133+137 .
    2. 杨英，王丽萍. 个性化优质护理在肺结核咯血患者行支气管动脉栓塞术后的临床价值. 临床医学研究与实践. 2021(01): 130-132 .
    3. 宋萍伟，桑桂凤，李红霞，姜娟. 咯血病人介入治疗时接污装置的设计与应用. 护理研究. 2021(01): 177-179 .
    4. 密芳，庞志敏，刘雨佳，张菁. 一体化链式急救模式在大咯血行支气管动脉栓塞术治疗患者中的应用. 中国现代医生. 2021(23): 177-180 .
    5. 饶争丽. 急救护理在肺结核伴发大咯血患者中的应用效果. 中华灾害救援医学. 2020(01): 37-39 .
    6. 林瑛，肖海燕，周通纲. 优质护理连续供给模式在大咯血行支气管动脉介入栓塞治疗患者中的应用. 齐鲁护理杂志. 2020(01): 103-105 .
    7. 万小艳. 全程优质护理配合支气管动脉栓塞对咳血患者病情转归及不良反应的影响. 医疗装备. 2020(05): 185-186 .
    8. 刘文丽. 中医护理模式辅助介入治疗肺动脉栓塞的临床观察. 中国民间疗法. 2019(11): 85-87 .
    9. 马忠丽，王梦娇，李艳. 围手术期全程护理在反复大咯血患者超选择支气管动脉栓塞术护理中的应用. 河南医学研究. 2019(20): 3788-3790 .
    10. 王万花，陈道琴，徐寒梅. 对进行支气管动脉栓塞术的患者实施预见性护理的效果分析. 当代医药论丛. 2019(19): 210-212 .
    11. 严文娟. 咯血患者支气管动脉栓塞术后不同护理方法的观察研究. 中国医药指南. 2019(30): 2-3 .
    12. 王建中，王筱，刘洋. 明胶海绵联合PVA颗粒支气管动脉栓塞治疗大咯血综合康复护理. 中外女性健康研究. 2019(23): 19-20+31 .
    13. 刘欢，万晓蓉. 优质护理在介入栓塞术救治急重症大咯血患者中的应用分析. 实用临床护理学电子杂志. 2019(46): 89-90 .
    14. 刘辉，刘慧. 对肺结核并发咯血患者进行全程护理的效果分析. 当代医药论丛. 2018(15): 198-199 .
    15. 覃金贞，党惠枝. 浅析支气管动脉栓塞止血术应用于治疗肺结核咯血的护理. 实用临床护理学电子杂志. 2018(15): 43+47 .
    16. 李秋丽. 大咯血患者介入治疗围术期优质护理效果观察. 中国校医. 2018(03): 226-227+229 .
    17. 王楠楠，王莉莉. 支气管动脉介入栓塞治疗大咯血患者应用优质护理的效果研究. 中西医结合心血管病电子杂志. 2018(23): 134-135 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (140) PDF downloads (11) Cited by(17)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return