| Citation: |
ZHANG Mingting, MAO Jianyun, XI Jianfen, HAN Wenjie, LI Zhuoqi, ZHAO Dongpo. Effects of probiotics combined with sacubitril valsartan and amiodarone on short-term and long-term efficacy of patients with atrial fibrillation after radiofrequency ablation[J]. Journal of Clinical Medicine in Practice, 2024, 28(9): 45-51. DOI: 10.7619/jcmp.20233642
|
To investigate the effects of probiotics combined with sacubitril valsartan and amiodarone on short-term and long-term efficacy of patients with atrial fibrillation after radiofrequency ablation.
A total of 90 patients with atrial fibrillation after radiofrequency ablation in the First Hospital of Zhangjiakou City from June 2021 to June 2022 were selected and randomly divided into three groups, with 30 cases in each group. Control group was treated with amiodarone, sacubitril valsartan group was treated with amiodarone and sacubitril valsartan, and probiotics group was treated with probiotics, amiodarone and sacubitril valsartan. The recurrence situation, atrial structure indexes[left atrial diameter (LAD), left ventricular ejection fraction (LVEF), left ventricular end systolic volume index (LVESVI), left atrial volume (LAV), left ventricular end diastolic volume index (LVEDVI)], myocardial fibrosis indexes[galactin-3 (Gal-3), soluble growth stimulation expression gene 2 protein (sST2)], inflammatory response indexes[intercellular adhesion molecule-1 (ICAM-1), C reactive protein (CRP), interleukin-6 (IL-6)], neuroendocrine hormone indexes[aldosterone, norepinephrine (NE), angiotensin Ⅱ (AngⅡ)], metabolites of gut microbiota[total bile acids, trimethylamine oxide (TMAO)] and incidence of adverse events were compared among the three groups.
At 12 months after treatment, the recurrence rate of the probiotics group was significantly lower than that of the sacubitril valsartan group and the control group (P < 0.05); after 3, 6 and 12 months of treatment, the LAD, LAV, LVESVI, LVEDVI, sST2 and Gal-3 in the probiotics group were significantly lower than those in the sacubitril valsartan group and the control group (P < 0.05), and these indexes in the sacubitril valsartan group were also significantly lower than those in the control group (P < 0.05); after 3, 6 and 12 months of treatment, the LVEF of the probiotics group was significantly higher than that of the sacubitril valsartan group and the control group (P < 0.05), and the LVEF of the sacubitril valsartan group was also significantly higher than that of the control group (P < 0.05); after 3, 6 and 12 months of treatment, the CRP, IL-6, ICAM-1, NE, aldosterone and AngⅡ in the probiotics group were significantly lower than those in the sacubitril valsartan group and the control group, and these indexes in the sacubitril valsartan group were also significantly lower than those in the control group (P < 0.05); after 3, 6 and 12 months of treatment, the TMAO and total bile acids in the probiotics group were significantly lower than those in the control group and the sacubitril valsartan group (P < 0.05); there was no significant difference in the incidence of adverse events among the three groups (P>0.05).
Probiotics combined with sacubitril valsartan and amiodarone can improve atrial structure after radiofrequency ablation of atrial fibrillation, inhibit myocardial fibrosis, reduce inflammatory response, regulate neuroendocrine hormones and metabolites of gut microbiota, prevent long-term recurrence of atrial fibrillation, and have a high safety.
| [1] |
REDDY V Y, DUKKIPATI S R, NEUZIL P, et al. Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT Ⅱ[J]. JACC Clin Electrophysiol, 2021, 7(5): 614-627. doi: 10.1016/j.jacep.2021.02.014
|
| [2] |
贾敏, 孙陈铃, 芮小文. 射频消融术后"空白期" 心房颤动患者的运动恐惧现状及其影响因素[J]. 实用临床医药杂志, 2023, 27(13): 93-98. doi: 10.7619/jcmp.20231228
|
| [3] |
吴昊. 肾动脉去神经术对提高持续性房颤射频消融术后无复发事件生存率的初步结果[D]. 杭州: 浙江大学, 2015.
|
| [4] |
AMAR D, ZHANG H, CHUNG M K, et al. Amiodarone with or without N-acetylcysteine for the prevention of atrial fibrillation after thoracic surgery: a double-blind, randomized trial[J]. Anesthesiology, 2022, 136(6): 916-926. doi: 10.1097/ALN.0000000000004201
|
| [5] |
于璠, 朱雪峰, 仲琳, 等. 沙库巴曲缬沙坦改善持续性心房颤动射频消融术后心脏结构与功能[J]. 内科急危重症杂志, 2022, 28(6): 482-486. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW202206012.htm
|
| [6] |
吴金春, 刘彦民, 苏晓灵. 肠道菌群/肠道微生态与心血管疾病发生的关系研究进展[J]. 解放军医学杂志, 2023, 48(7): 851-855. https://www.cnki.com.cn/Article/CJFDTOTAL-JFJY202307016.htm
|
| [7] |
张芳, 夏振伟, 冯磊, 等. 阵发性房颤射频消融术后应用胺碘酮对复发率影响的研究[J]. 中国实用医药, 2016, 11(19): 10-11. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA201619005.htm
|
| [8] |
张骏, 高玉英, 李巧, 等. 沙库巴曲缬沙坦对持续性房颤患者心脏结构及功能的影响[J]. 重庆医学, 2023, 52(1): 72-76. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX202301015.htm
|
| [9] |
赵玉清, 刘恒, 杨亚楠, 等. 沙库巴曲缬沙坦联合胺碘酮治疗合并阵发性房颤的老年性心力衰竭的疗效观察[J]. 河北医药, 2019, 41(3): 404-406, 410. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201903019.htm
|
| [10] |
王猛, 江洪. 肠道菌群及其代谢产物与心房颤动的研究进展[J]. 心血管病学进展, 2022, 43(3): 214-217. https://www.cnki.com.cn/Article/CJFDTOTAL-XXGB202203006.htm
|
| [11] |
BOCKERIA O L, KANAMETOV T N, SHVARTZ V A, et al. Epicardial application of hydrogel with amiodarone for prevention of postoperative atrial fibrillation in patients after coronary artery bypass grafting[J]. J Cardiovasc Transl Res, 2020, 13(2): 191-198. doi: 10.1007/s12265-019-09905-1
|
| [12] |
MANN D L, GIVERTZ M M, VADER J M, et al. Effect of treatment with sacubitril/valsartan in patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial[J]. JAMA Cardiol, 2022, 7(1): 17-25. doi: 10.1001/jamacardio.2021.4567
|
| [13] |
罗彬, 崔檬, 王佳贺. 肠道菌群与心血管疾病的研究进展[J]. 中国临床保健杂志, 2021, 24(3): 315-319. https://www.cnki.com.cn/Article/CJFDTOTAL-LZBJ202103007.htm
|
| [14] |
乐世俊, 王文晓, 陶慧娟, 等. 肠道菌群-TMA-TMAO代谢途径与心血管疾病的研究进展[J]. 中华心血管病杂志, 2020, 48(2): 159-163.
|
| [15] |
张婉馨, 彭丽艳, 贺巍, 等. 沙库巴曲缬沙坦联合胺碘酮对老年HF伴PAF患者心功能、炎症因子及神经内分泌激素的影响[J]. 现代生物医学进展, 2021, 21(2): 254-258. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202102013.htm
|
| [16] |
孙春玲, 吴进寿, 金哲秀, 等. 沙库巴曲缬沙坦钠联合胺碘酮对房颤射频消融术后患者心房重构及炎性因子的影响[J]. 中国现代药物应用, 2021, 15(24): 204-206. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202124079.htm
|
| [17] |
杨东, 骆昌云, 刘川, 等. 急性心力衰竭合并房颤患者sST2、BNP、AngⅡ的表达及意义[J]. 解放军医药杂志, 2022, 34(2): 79-82. https://www.cnki.com.cn/Article/CJFDTOTAL-HBGF202202018.htm
|
| [18] |
许鹏, 边兴花, 王宇航. 冠心病患者行经皮冠状动脉介入术后脂肪因子、炎性因子与肠道菌群对主要不良心血管事件的影响[J]. 实用临床医药杂志, 2023, 27(13): 81-86. doi: 10.7619/jcmp.20231409
|
| [19] |
郭俊霞, 张艳贞, 陈文. 益生菌改善代谢综合征研究进展[J]. 食品安全质量检测学报, 2014, 5(6): 1583-1588.
|
| [1] | JIA Min, SUN Chenling, RUI Xiaowen. Current situation of exercise fear in patients with atrial fibrillation during "blank period" after radiofrequency ablation and its influencing factors[J]. Journal of Clinical Medicine in Practice, 2023, 27(13): 93-98. DOI: 10.7619/jcmp.20231228 |
| [2] | SUN Haili, SHEN Aiwu, CHEN Ken. The causes of acute recurrent pancreatitis and endoscopic therapy[J]. Journal of Clinical Medicine in Practice, 2022, 26(20): 81-84. DOI: 10.7619/jcmp.20221627 |
| [3] | YANG Yichen, ZOU Cao. Radiofrequency catheter ablation versus cryoballoon ablation for atrial fibrillation in long-term follow up results[J]. Journal of Clinical Medicine in Practice, 2022, 26(12): 10-13. DOI: 10.7619/jcmp.20220369 |
| [4] | DONG Yanping, WANG Jiemin, WANG Yujin, REN Yali, DONG Yucheng, YONG Yanjun, SU Xuandi, WANG Jixiang, SU Nan, WANG Fuli, XIA Duosheng. Construction and evaluation of Nomogram prediction model for postoperative recurrence of pterygium[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 52-56. DOI: 10.7619/jcmp.20214610 |
| [5] | YANG Chengying, WEI Ting, PAN Min, ZENG Di. Research progress on perioperative nursing for radiofrequency ablation of atrial fibrillation[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 115-119. DOI: 10.7619/jcmp.20200970 |
| [6] | DAN Dan, ZHANG Li, HUANG Xiujuan, PENG Yinqiong. Effect of comprehensive nursing intervention on the isease cognition and recurrence after lithotripsy in patients with urinary calculi[J]. Journal of Clinical Medicine in Practice, 2016, (20): 89-91. DOI: 10.7619/jcmp.201620028 |
| [7] | LIU Guangan, LIU Fei, CHEN Runxiang, WU Jingjing, YOU Binquan, CHENG Hai, WANG Bingyin. Short-term efficacy and safety of CARTO-guided ablation in treatment of 153 patients with atrial fibrillation[J]. Journal of Clinical Medicine in Practice, 2015, (9): 12-17. DOI: 10.7619/jcmp.201509004 |
| [8] | CHEN Jinghua, TANG Hui, YU Chuanhu, LI Wei. Research on recurrent situation and risk factors of endometrial cancer[J]. Journal of Clinical Medicine in Practice, 2013, (13): 145-147. DOI: 10.7619/jcmp.201313053 |
| [9] | ZHANG Wenping, WU Xin, BU Jian. Clinical observation and nursing experience of patients with recurrent calculus of extrahepatic and intrahepatic duct[J]. Journal of Clinical Medicine in Practice, 2013, (10): 64-66. DOI: 10.7619/jcmp.201310024 |
| [10] | XU Zhuowen, ZHENG Ruolong, LI Weizhang, CHEN Jianbo, QIAN Huidong, CHEN Xinjun. Impact of obstructive sleep apnea syndrome on the recurrent rate of patients with atrial fibrillation after radiofrequency ablation[J]. Journal of Clinical Medicine in Practice, 2013, (9): 23-25. DOI: 10.7619/jcmp.201309007 |
© 2020 《实用临床医药杂志》编辑部
Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807
Supported by:
Beijing Renhe Information Technology Co., Ltd.
苏公网安备 32100302010246号
DownLoad: