Objective To investigate the therapeutic effect of Tongluo Yangxin Recipe combined with anti-hypertensive drugs in the treatment of hypertension patients complicated with left ventricular diastolic dysfunction and its influence on cardiac function and ventricular remodeling indexes.
Methods A total of 60 hypertension patients complicated with left ventricular diastolic dysfunction in Jiangsu Provincial Hospital of Traditional Chinese Medicine were selected as the research objects, and they were randomly divided into study group and control group, with 30 cases in each group. The study group was treated with anti-hypertensive drugs and traditional Chinese medicine decoction, while the control group was treated with conventional anti-hypertensive therapy. The clinical efficacy, systolic blood pressure, diastolic blood pressure, echocardiographic ventricular remodeling indexes, and left ventricular diastolic indexes were compared between the two groups.
Results After treatment, the total effective rate in the study group was 90.00%, which was significantly higher than 66.67% in the control group (P < 0.05); after treatment, the total score of TCM syndromes in the study group was significantly lower than that in the control group (P < 0.05). After treatment, both systolic and diastolic blood pressures decreased significantly in both groups when compared with those before treatment, and systolic and diastolic blood pressures in the study group were significantly lower than those in the control group (P < 0.05). Before and after treatment, there were no significant between-group and intra-group differences in left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWd), and left ventricular ejection fraction (LVEF) between the study group and the control group (P>0.05). The improvement conditions of the ratio of peak flow velocity in early diastole to peak flow velocity in late diastole (E/A), the ratio of peak flow velocity in early diastole at the mitral orifice to peak flow velocity in early diastole at the lateral wall and interventricular septum of the mitral annulus (E/e'), and E peak deceleration time (EDT) in the study group after treatment were significantly better than those in the control group (P < 0.05). The incidence of adverse reactions was 23.33% in the study group and 26.67% in the control group, and there was no significant difference between the two groups (P>0.05).
Conclusion Application of Tongluo Yangxin Recipe on the basis of anti-hypertensive drugs can improve the clinical symptoms and efficacy of hypertension patients complicated with left ventricular diastolic dysfunction without affecting ventricular remodeling indexes.
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