A research on cerebral limbic-cortical circuit in patients with chronic obstructive pulmonary disease complicated with depression

WANG Longlong; XU Shudi; MA Hongge; MA Jingwen; WANG Jingjian; YANG Shuhan; ZHANG Min

doi:10.7619/jcmp.20215107

Journal of Clinical Medicine in Practice > 2022 > 26(11): 38-41. > DOI: 10.7619/jcmp.20215107

WANG Longlong, XU Shudi, MA Hongge, MA Jingwen, WANG Jingjian, YANG Shuhan, ZHANG Min. A research on cerebral limbic-cortical circuit in patients with chronic obstructive pulmonary disease complicated with depression[J]. Journal of Clinical Medicine in Practice, 2022, 26(11): 38-41. DOI: 10.7619/jcmp.20215107

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A research on cerebral limbic-cortical circuit in patients with chronic obstructive pulmonary disease complicated with depression

1.
Department of Medical Imaging, the First Affiliated Hospital of Xi′an Jiaotong University, Xi′an, Shaanxi, 710061
2.
the Ninth Hospital of Xi′an City in Shaanxi Province, Xi′an, Shaanxi, 710054

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Received Date: December 23, 2021
Available Online: May 13, 2022

Graphical Abstract

Abstract

Abstract

Objective
To explore the change of gray matter volume in limbic-cortical circuit in patients with chronic obstructive pulmonary disease (COPD)complicated with depression by using voxel-based morphometry (VBM).
Methods
A total of 22 patients with COPD complicated with depression were prospectively selected as COPD complicated with depression group, and 20 healthy subjects matched by gender and age were selected as control group. T2-FLAIR and high-resolution 3d-T1WI were performed, and the change of cerebral gray matter volume in both groups was analyzed by COPDAssessment Test (CAT) and SPM12 software.
Results
The results of VBM showed that the volumes of gray matter in left frontal lobe, bilateral paracentral lobules, bilateral anterior cingulate gyrus, left central and left posterior cingulate gyrus, left dorsal thalamus, hypothalamus, bilateral amygdala and bilateral cerebellum significantly decreased in patients with COPD complicated with depression compared with the control group (P < 0.05).
Conclusion
Patients with COPD complicated with depression present gray matter volume reduction in multiple regions of limbic-cortical circuitry, which can provide reference for clinical prevention, treatment and intervention.
- voxel-based morphometry,
- chronic obstructive pulmonary disease,
- depression,
- limbic-cortical circuitry,
- cerebral gray matter,
- hypothalamus,
- amygdala

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References (18)

References

[1]	李思其, 高兴林. 《慢性阻塞性肺疾病全球倡议》2021年版更新解读[J]. 临床药物治疗杂志, 2021, 19(5): 36-42. doi: 10.3969/j.issn.1672-3384.2021.05.008
[2]	黄菲菲, 秦继山. 中老年慢性阻塞性肺疾病临床特征与病情进展的相关性[J]. 实用临床医药杂志, 2021, 25(1): 45-49, 53. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202101012.htm
[3]	DENGX Y, FUJ, SONGY, et al. Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: a potential mechanism underlying the cross talk between lung and brain[J]. Brain Behav Immun, 2019, 79: 195-206. doi: 10.1016/j.bbi.2019.02.001
[4]	陈琰, 钱频, 袁琳, 等. 慢性阻塞性肺疾病肺外合并症的治疗现状和研究进展[J]. 中华肺部疾病杂志: 电子版, 2020, 13(1): 100-103. doi: 10.3877/cma.j.issn.1674-6902.2020.01.025
[5]	苏建花, 程克文, 陈小东. 脑钠肽在慢性阻塞性肺疾病中的应用进展[J]. 医学综述, 2017, 23(23): 4677-4682. doi: 10.3969/j.issn.1006-2084.2017.23.019
[6]	王芳, 沈文超, 胡笑楠, 等. 皮质-基底神经节-丘脑-皮质环路与抑郁症状调节的机制探讨[J]. 临床精神医学杂志, 2021, 31(4): 326-329. doi: 10.3969/j.issn.1005-3220.2021.04.024
[7]	俞元临, 肖泽彬, 张桦, 等. 阿尔茨海默病及轻度认知障碍所致脑灰质体积及脑功能改变[J]. 中国医学影像技术, 2021, 37(2): 200-205. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXX202102013.htm
[8]	陈苑, 姜雨, 陈艺, 等. 首发早发性抑郁症患者脑灰质体积及结构协变网络的异常改变[J]. 中华放射学杂志, 2021, 55(9): 941-947. doi: 10.3760/cma.j.cn112149-20201126-01260
[9]	VERBERKT C A, VANDEN BEUKEN-VAN EVERDINGEN M H J, DIRKSEN C D, et al. Cost-effectiveness of sustained-release morphine for refractory breathlessness in COPD: a randomized clinical trial[J]. Respir Med, 2021, 179: 106330. doi: 10.1016/j.rmed.2021.106330
[10]	彭兆辉, 杨林峰, 彭兆伟, 等. 基于VBM研究中度至重度COPD患者脑灰质体积变化[J]. 医学影像学杂志, 2019, 29(11): 1832-1836. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXZ201911005.htm
[11]	刘春梅, 王春美, 吴立山, 等. 基于体素的形态学方法对抑郁症患者的脑结构磁共振研究[J]. 中风与神经疾病杂志, 2021, 38(7): 606-608. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFSJ202107006.htm
[12]	CHIN FATT C R, JHA M K, MINHAJUDDIN A, et al. Dysfunction of default mode network is associated with active suicidal ideation in youths and young adults with depression: findings from the T-RAD study[J]. J Psychiatr Res, 2021, 142: 258-262. doi: 10.1016/j.jpsychires.2021.07.047
[13]	鲁毅. 首发未治疗抑郁症患者脑结构的多模态影像学研究[D]. 昆明: 昆明医科大学, 2017.
[14]	BERBOTH S, MORAWETZ C. Amygdala-prefrontal connectivity during emotion regulation: a meta-analysis of psychophysiological interactions[J]. Neuropsychologia, 2021, 153: 107767. doi: 10.1016/j.neuropsychologia.2021.107767
[15]	STOODLEY C J, SCHMAHMANN J D. Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies[J]. Neuroimage, 2009, 44(2): 489-501. doi: 10.1016/j.neuroimage.2008.08.039
[16]	闫晓培, 石宝玉, 王慧, 等. 慢性阻塞性肺疾病伴高血压病的临床特征和危险因素分析[J]. 实用临床医药杂志, 2021, 25(3): 63-68. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202103016.htm
[17]	邹君惠, 高圆圆, 秦若梦, 等. 高血压病患者脑白质高信号体积与认知功能的相关性分析[J]. 中华神经科杂志, 2019, 52(3): 190-196.
[18]	YU L C, DE MAZANCOURT M, HESS A, et al. Functional connectivity and information flow of the respiratory neural network in chronic obstructive pulmonary disease[J]. Hum Brain Mapp, 2016, 37(8): 2736-2754. doi: 10.1002/hbm.23205

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A research on cerebral limbic-cortical circuit in patients with chronic obstructive pulmonary disease complicated with depression