Advance Search
DING Yongj uan, LYU Juan, GUO Jing, BIAN Yun. Influence of atorvastatin intensive treatment on blood lipid and the level of serum hs-CRP and MMP-9 in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2014, (17): 12-14,21. DOI: 10.7619/jcmp.201417004
Citation: DING Yongj uan, LYU Juan, GUO Jing, BIAN Yun. Influence of atorvastatin intensive treatment on blood lipid and the level of serum hs-CRP and MMP-9 in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2014, (17): 12-14,21. DOI: 10.7619/jcmp.201417004
shu

Influence of atorvastatin intensive treatment on blood lipid and the level of serum hs-CRP and MMP-9 in patients with acute coronary syndrome

More Information
  • Published Date: October 16, 2014
    Graphical Abstract
    • Abstract
  • Obj ective To explore the influence of atorvastatin intensive treatment on blood lipid and the level of serum high-sensitivity C-reactive protein (hs-CRP )and matrix metallopro-teinase (MMP-9)in patients with acute coronary syndrome (ACS).Methods A total of 131 pa-tients with ACS performed with percutaneous coronary intervention (PCI )in our hospital were se-lected and randomly divided into 2 groups,namely conventional group (63 cases )and intensive group (68 cases).Conventional group was given atorvastatin conventional treatment while intensive group was given atorvastatin intensive treatment.After 4 weeks,the level of blood lipid hs-CRP and MMP-9 and the occurrence of adverse reactions were recorded and the conditions of prognosis were observed.Results After 4 weeks,the levels of total cholesterol,triglyceride,low density lipoprotein,hs-CRP and MMP-9 in intensive group were lower than treatment before and control group (P<0.05,or P<0.01).High-density lipoprotein was significantly higher than treatment before and conventional group (P<0 .0 1 ).There was no adverse reactions in conventional group but slighter in intensive group,with good tolerance.At the end of the follow-up,the prognosis of intensive group was superior to conventional group (P<0 .05 ).Conclusion Compared with con-ventional treatment,atorvastatin intensive treatment has an better effect on ACS,capable of obvi-ously improving the clinical benefit of patients.
    • FullText(HTML)
    • References (16)
  • Aseri Z A, Habib S S, Alhomida A S. Relationship of high sensitivity C-reactive protein with cardiac biomarkers in patients presenting with a cute coronary syndrome [J]. J Col Physicians Surg Pak, 2014(6):387.
    Barrabé s J A, Bardají A, Jimé nez-Candil J. Prognosis and Management of Acute Coronary Syndrome in Spain in 2012:The DIOCLES Study [J]. Revista Espanola de Cardiologia, 2014.
    Zhao S P, Yu B L, Peng D Q. The effect of moderate-dose versus double-dose statins on patients with acute coro-nary syndrome in China:Results of the CHILLAS trial [J]. ATHEROSCLEROSIS, 2014(2):707.
    Vecchio S, Varani E, Chechi T. Coronary thrombus in patients undergoing primary PCI for STEMI:Prognostic sig-nificance and management [J]. World J Cardiol, 2014(6):381.
    Ibrahim A W, Riddel T C, Devireddy C M. Acute Myocar-dial Infarction [J]. CRITICAL CARE CLINICS, 2014(3):341.
    王大强, 王革新. 阿托伐他汀对PCI冠心病CHF患者NT-proBNP、hs-CRP和左室重构的影响 [J]. 中国现代医学杂志, 2012(3):59.
    孙斌. 住院急性综合征患者血脂水平及其治疗现状调查 [D]. 郑州:郑州大学, 2010.
    赵晓平, 张林, 黄远东. 他汀类药物在心血管疾病二级预防中的研究现状 [J]. 四川医学, 2009(1):147.doi: 10.3969/j.issn.1004-0501.2009.01.073.
    Li X P, Gong H R, Zhao S P. The lipid-regulating ef-fect and safety of combined statin and bezafibrate therapy in acute coronary syndrome patients complicating with dyslipi-demia [J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2013, (12):1006.
    Guo C, Zhang S, Zhang J. Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9 [J]. Exp Ther Med, 2014(5):1177.
    Raposeiras Roubín S, Barreiro Pardal C, Roubín-Cami?a F. High-sensitivity C-reactive protein predicts adverse out-comes after non-ST-segment elevation acute coronary syn-drome regardless of GRACE risk score, but not after ST-seg-ment elevation myocardial infarction [J]. Revista Portuguesa de Cardiologia, 2013(2):117.
    Dabek J, Glogowska-Ligus J, Szadorska B. Transcription ac-tivity of MMP-2 and MMP-9 metal oproteinase genes and their tissue inhibitor (TIMP-2)in acute coronary syndrome patients [J]. Journal of Postgraduate Medicine, 2013(2):115.
    Lee R. Matrix metal oproteinase-9 in patients with acute coronary syndrome [J]. Chinese Medical Journal(Engl), 2012(4):720.
    Prasad A, Pratim Datta P, Roy R. Comparative study of ezetimibe and atorvastatin alone and in combination on lipid profile in rats [J]. Master Sociomed, 2013(3):192.
    Rosa G M, Carbone F, Parodi A. Update on the effi-cacy of statin treatment in acute coronary syndromes [J]. European Journal of Clinical Investigation, 2014(5):501.
    Sindhu S, Singh H K, Salman M T. Effects of ator-vastatin and rosuvastatin on high-sensitivity C-reactive pro-tein and lipid profile in obese type 2 diabetes mel itus patients [J]. J Pharmacol Pharmacother, 2011(4):261.
    • Related Articles

  • Related Articles

    [1]LIU Ying, DU Likun, HU Lingdan, DU Zhiqiang, CUI Jing. Expression and significance of matrix metalloproteinases and toll-like receptor 9 in patients with acute leukemia[J]. Journal of Clinical Medicine in Practice, 2024, 28(15): 120-123, 129. DOI: 10.7619/jcmp.20240984
    [2]ZHANG Lanfang, CHEN Xu, KUAI Jun, QIN Lei, YANG Yan, CHANG Tingmin. Effect of tegafur, gimeracil and oteracil potassium combined with oxaliplatin on gastric motility-related hormones, matrix metalloproteinase-2 and matrix metalloproteinase-9 in elderly patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(12): 57-60, 65. DOI: 10.7619/jcmp.20241047
    [3]SUN Ling, LI Tantan, WU Xifeng, MEN Lijie, JIA Meiyan, LU Jun. Correlations of serum tissue inhibitor of metalloproteinases-1, matrix metalloproteinase-9 and vascular endothelial growth factor with degree of myelofibrosis in patients with myeloproliferative neoplasms[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 34-40. DOI: 10.7619/jcmp.20234037
    [4]SHAN Na, ZHAO Li, LIN Xiaodong. Predictive value of serum matrix metalloproteinase-9 and neurofilament light chain levels for cognitive impairment patients after first-onset ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 67-70, 90. DOI: 10.7619/jcmp.20230606
    [5]WANG Fei, SHI Meihong. Relationships of BTB/POZ domain-containing protein 7 and matrix metalloproteinase-9 expression with autoantibodies in labial gland tissues of patients with primary Sjögren's syndrome[J]. Journal of Clinical Medicine in Practice, 2022, 26(21): 98-102. DOI: 10.7619/jcmp.20220899
    [6]YUAN Shanqi, ZHAO Hongmin, WANG Xiaoye, ZHANG Xi′an, HOU Pengfei, LIU Zhanhui. Application analysis of carotid ultrasound combined with detections of vascular endothelial growth factor, matrix metalloproteinase-9 and hypersensitive C-reactive protein in the stability of atherosclerotic plaque[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 27-29, 33. DOI: 10.7619/jcmp.201917008
    [7]ZHANG Yan, TU Jing, HUANG Hui. Study on the correlation between serum adiponectin and placental matrix metalloproteinase 9 in patients with gestational hypertension[J]. Journal of Clinical Medicine in Practice, 2017, (3): 96-98. DOI: 10.7619/jcmp.201703029
    [8]LU Jianjun, YI Liping, TUO Ya, QIAO Huizhen. Expression and clinical significance of matrix metalloproteinases-9 in tissues of endometrial carcinoma[J]. Journal of Clinical Medicine in Practice, 2014, (15): 63-65,69. DOI: 10.7619/jcmp.201415019
    [9]GAO Mingjun, QI Bo. Influence of irbesartan and amlodipine on carotid-femoral artery pulse wave velocity and serum matrix metalloproteinase-9 level in patients with primary hypertension[J]. Journal of Clinical Medicine in Practice, 2013, (23): 12-14,18. DOI: 10.7619/jcmp.201323004
    [10]ZHANG Yuhua, CAI Xiangzeng, GUO Minghe. Effects of Chuanxiongqin on serum high-sensitivity C-reactive protein, interleukin-6 and matrix metalloproteinases-9 in treating acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2013, (17): 78-80. DOI: 10.7619/jcmp.201317026

  • Cited by

    Periodical cited type(3)

    1. 王娟，郭潍宁，陆小莉，章馨，陶云，沈薛. 妊娠期胎动监测与胎动减少管理最佳证据总结. 全科护理. 2024(17): 3169-3175 .
    2. 姚娟娟，黄秀霞，岳智慧，邓瑾微. 导乐联合哀伤护理在围产期丧失产妇护理中的应用效果. 中国社区医师. 2023(32): 142-144 .
    3. 程彩霞. 单胎妊娠晚期胎死宫内的病因分析与预防策略. 实用妇科内分泌电子杂志. 2023(35): 47-49 .

    Other cited types(0)

Catalog

    Get Citation
    XML
    Article views (373) PDF downloads (0) Cited by(3)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return