Effect of oral administration of aspirin and lipitorin combination for patients with different types of carotid plaques

WANG Mingqi; HUANG Lingyan; CHEN Lin

doi:10.7619/jcmp.201917011

Journal of Clinical Medicine in Practice > 2019 > 23(17): 39-41. > DOI: 10.7619/jcmp.201917011

WANG Mingqi, HUANG Lingyan, CHEN Lin. Effect of oral administration of aspirin and lipitorin combination for patients with different types of carotid plaques[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 39-41. DOI: 10.7619/jcmp.201917011

Citation:

PDF (483 KB)

Effect of oral administration of aspirin and lipitorin combination for patients with different types of carotid plaques

Ganzhou People′s Hospital in Jiangxi Province, Ganzhou, Jiangxi, 341000

More Information

Received Date: July 13, 2019
Accepted Date: August 22, 2019
Available Online: February 28, 2021
Published Date: September 14, 2019

Graphical Abstract

Abstract

Abstract

Objective To investigate the effect of oral administration of aspirin and lipitor in combination for patients with different types of carotid plaques.
Methods A total of 80 patients with carotid artery plaques in our hospital were divided into soft plaque group (n=45), mixed type plaque group(n=16)and hard plaque group (n=19). Patients of three groups were given oral administration of aspirin and lipitor in combination. The plaque size, serum inflammatory index and blood lipid of the three group before treatment and 6, 12 months after treatment were compared.
Results Compared with before treatment, soft plaque group and mixed plaque group were significantly smaller at 6 and 12 months after treatment (P < 0.05), and the outcomes at 12 months was better than at 6 months, but the size of hard plaque group has no obvious change(P>0.05). Compared with before treatment, the serum hypersensitive C reactive protein (hs-CRP), plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) at 6 and 12 months after treatment of three groups were significantly decreased, but high-density lipoprotein (HDL-C) was increased(P < 0.05), and the results of at 12 months after treatment was better than that at 6 months after treatment.
Conclusion Combined oral administration of aspirin and lipitor can significantly reduce the soft and mixed type of carotid artery plaques, and it can improve patients′serum inflammatory reaction and lipid levels, but the effect of hard plaques treatment is not obvious.
- carotid plaque,
- aspirin,
- lipitor,
- serum index,
- carotid intima-media thickness,
- plaque area

FullText(HTML)

References (15)

References

[1]	李志刚, 曹惠洁, 袁建清, 等. 阿司匹林与立普妥联合口服对不同类型颈动脉斑块的治疗效果[J]. 山东医药, 2016, 56(43): 50-52. doi: 10.3969/j.issn.1002-266X.2016.43.015
[2]	张起顺, 陈勇, 王朝辉, 等. 阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的临床观察[J]. 中国药房, 2017, 28(12): 1603-1605. doi: 10.6039/j.issn.1001-0408.2017.12.06
[3]	杨雪, 李楠, 王海兵. 不同剂量瑞舒伐他汀对中国人颈动脉粥样硬化斑块影响的Meta分析[J]. 第三军医大学学报, 2016, 38(3): 233-237. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX201603004.htm
[4]	秦海凤, 徐进, 郭娇. 化浊通脉汤对高血压合并颈动脉斑块患者的影响[J]. 中国实验方剂学杂志, 2015, 14(21): 156-159. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201521039.htm
[5]	曾妍, 陈卫钦. 瑞舒伐他汀联用厄贝沙坦逆转颈动脉斑块的研究[J]. 中国现代医学杂志, 2015, 25(34): 31-34. doi: 10.3969/j.issn.1005-8982.2015.34.008
[6]	宋梅, 田玉和. 瑞舒伐他汀治疗对颈动脉斑块以及炎性因子的影响[J]. 中国地方病防治杂志, 2017, 21(2): 182-183. https://www.cnki.com.cn/Article/CJFDTOTAL-DYBF201702032.htm
[7]	王焕君, 李严, 吴强, 等. 通心络、阿托伐他汀联合脑超声波治疗对颈动脉易损斑块的干预研究[J]. 中国急救医学, 2015, 35(s2): 367-368. https://cpfd.cnki.com.cn/Article/CPFDTOTAL-ZGZP201509001073.htm
[8]	黄群莲, 向淑利, 胡运春, 等. 活血通脉片对颈动脉易损斑块的干预作用[J]. 中国实验方剂学杂志, 2017, 12(8): 184-189. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201708032.htm
[9]	关利利, 张洪剑. 阿托伐他汀联合阿司匹林治疗脑梗死合并颈动脉斑块的疗效观察[J]. 中西医结合心脑血管病杂志, 2016, 14(6): 646-648. doi: 10.3969/j.issn.1672-1349.2016.06.031
[10]	陈国威, 王迎. 不同剂量瑞舒伐他汀对不同性质颈动脉斑块的疗效观察[J]. 心脑血管病防治, 2015, 13(5): 386-387. doi: 10.3969/j.issn.1009-816x.2015.05.12
[11]	郭晓玲, 李琳, 李岩, 等. 不同剂量纤溶酶联合他汀类药物治疗颈动脉硬化斑块临床效果分析[J]. 中国医药, 2016, 11(12): 1781-1784. doi: 10.3760/cma.j.issn.1673-4777.2016.12.010
[12]	张建强, 高红安, 宋程光, 等. 普罗布考联合阿司匹林溶解治疗颈动脉斑块脑梗死的临床效果观察[J]. 现代生物医学进展, 2017, 17(5): 919-922. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201705032.htm
[13]	梁文华, 王跃慧. 阿托伐他汀与拜阿司匹林联合治疗方案对缺血性脑卒中患者颈动脉斑块以及疾病复发率的影响[J]. 山西医药杂志, 2016, 45(18): 2147-2150. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY201618022.htm
[14]	Wang J, Ai X B, Wang F, et al. Efficacy of ezetimibe combined with atorvastatin in the treatment of carotid artery plaque in patients with type 2 diabetes mellitus complicated with coronary heart disease[J]. Int Angiol, 2017, 36(5): 467-473.
[15]	Masson W, Lobo M, Molinero G, et al. Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol[J]. Arq Bras Cardiol, 2017, 108(6): 526-532. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489322/

[1]	XU Hao, LIU Jiaoran, GAO Bojian, ZHANG Rongxin, WANG Tianya. Value of biopsy by contrast-enhanced ultrasound in diagnosis of nature of type 4 thyroid nodules by thyroid imaging reporting and data system[J]. Journal of Clinical Medicine in Practice, 2025, 29(7): 8-12. DOI: 10.7619/jcmp.20244230
[2]	ZHU Xin, PAN Tingting, ZHAO Qingqing, XIE Nanchang. Construction of sensitive indexes of care quality in patients with epilepsy[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 121-125. DOI: 10.7619/jcmp.20233521
[3]	CHENG Mei, LI Liming, BAI Xiangwei, YUAN Mengyang, YUAN Fangfang. Construction of sensitive indicators of quality of emergency nursing in patients with acute aortic dissection[J]. Journal of Clinical Medicine in Practice, 2024, 28(6): 124-128. DOI: 10.7619/jcmp.20232842
[4]	SHI Guoqiang, GU Fuyan, NIU Weikang, LI Xilong. Impact of lidocaine on the chemotherapy sensitivity of gastric cancer cells via regulating Wnt/β-catenin axis[J]. Journal of Clinical Medicine in Practice, 2024, 28(1): 28-36. DOI: 10.7619/jcmp.20233272
[5]	XIONG Yongqun, HE Yushen, XIE Peiwen, ZHENG Yi, LIN Jianwei, LI Yuancun, ZHANG Guihua. Sensitivity and specificity of fundus photograph in detecting diabetic macular edema[J]. Journal of Clinical Medicine in Practice, 2023, 27(18): 44-48. DOI: 10.7619/jcmp.20232028
[6]	LIANG Liyan, BAOLATEJIANG Ruozha, LIU Shunmin, WANG Shengfang. Value of plasma microRNA-126 and microRNA-130 in evaluating prognosis of acute myocardial infarction after emergency percutaneous coronary intervention[J]. Journal of Clinical Medicine in Practice, 2022, 26(16): 82-86, 95. DOI: 10.7619/jcmp.20220905
[7]	LI Xunfei, YU Ju. Construction of nursing quality sensitive index of peripheral venous indwelling needle[J]. Journal of Clinical Medicine in Practice, 2022, 26(13): 130-133. DOI: 10.7619/jcmp.20220174
[8]	XIA Jinxing, LU Fanbo, HUANG Wei, XU Yuanhong. Clinical characteristics, antifungal sensitivity and risk factors of invasive Candida infection in sterile sites[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 1-7. DOI: 10.7619/jcmp.20214963
[9]	GUO Huafeng, WANG Xiaonan, YANG Lu. Application of multi-slice spiral CT combined with MRI in diagnosis of cerebral infarction and cerebral hemorrhage[J]. Journal of Clinical Medicine in Practice, 2020, 24(23): 8-10,14. DOI: 10.7619/jcmp.202023003

Cited By

Cited by

Periodical cited type(5)

1.	刘文通. 甲状腺功能5项对鉴别诊断甲状腺功能亢进和甲状腺功能减退中的价值研究. 黑龙江中医药. 2024(01): 359-361 .
2.	蒋瑞妹，王卓群，牛敏，申金付，秦瑶，李娟. 骨吸收标志物β-CTX与Graves病患者并发高钙血症的相关性. 中国医师杂志. 2023(04): 528-531, 536 .
3.	祖力皮亚·努尔买买提，热依汗尼沙·亚克亚，阿不都力木·斯迪克. 普萘洛尔辅助丙硫氧嘧啶治疗老年甲状腺亢进的疗效及对糖脂代谢和ACTH水平的影响. 中外医疗. 2023(23): 92-95 .
4.	乔辉，丁红娜，孙君. 甲状腺功能亢进患者骨密度、骨代谢、脂肪细胞因子的相关性. 河南医学研究. 2023(22): 4091-4095 .
5.	郭小妮，刘师伟，段瑞雪，赵宇翔，吴亚茹. 脂肪因子vaspin与骨质疏松症相关性的研究进展. 生命的化学. 2022(10): 1905-1912 .

Other cited types(1)

Get Citation

PDF

XML

Article views (323) PDF downloads (10) Cited by(6)

Turn off MathJax

Article Contents

Abstract

References

Effect of oral administration of aspirin and lipitorin combination for patients with different types of carotid plaques

Abstract

References

Related Articles

Cited by

Periodical cited type(5)

Other cited types(1)

Catalog

Effect of oral administration of aspirin and lipitorin combination for patients with different types of carotid plaques

Abstract

References

Related Articles

Cited by

Periodical cited type(5)

Other cited types(1)

Catalog

Export File

Citation

Format

Content