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ZHANG Liwei. Correlations between serum uric acid, N-terminal pro-B-type natriuretic peptide, vasostatin-2 and left ventricular ejection fraction in patients with chronic heart failure[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 29-31. DOI: 10.7619/jcmp.202012008
Citation: ZHANG Liwei. Correlations between serum uric acid, N-terminal pro-B-type natriuretic peptide, vasostatin-2 and left ventricular ejection fraction in patients with chronic heart failure[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 29-31. DOI: 10.7619/jcmp.202012008
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Correlations between serum uric acid, N-terminal pro-B-type natriuretic peptide, vasostatin-2 and left ventricular ejection fraction in patients with chronic heart failure

  • Liaoyang City Central Hospital, Liaoyang, Liaoning, 111000

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  • Received Date: February 10, 2020
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    • Abstract
  • Objective To explore the correlations between serum uric acid(UA), N-terminal pro-B-type natriuretic peptide(NT-proBNP), vasostatin-2(VS-2)and left ventricular ejection fraction(LVEF)in patients with chronic heart failure(CHF). Methods According to cardiac function classification standard of the New York Heart Association(NYHA), 160 patients with CHF were divided into grade Ⅰ group, grade Ⅱ group, grade Ⅲ group and grade Ⅳ group, with 40 cases in each group. The levels of UA, NT-proBNP, VS-2 and LVEF were compared among the four groups, and the correlations between serum UA, NT-proBNP, VS-2 and LVEF were analyzed. Results In the grade Ⅰ, Ⅱ, Ⅲ and Ⅳ groups, the levels of NT-proBNP and UA increased gradually while the levels of VS-2 and LVEF decreased gradually, and there were significant differences among the four groups(P<0.05). Correlation analysis showed that serum VS-2 was positively correlated with LVEF(r=0.664, P=0.001), and serum NT-proBNP as well as UA levels were negatively correlated with LVEF(r=-0.645, -0.518, P=0.002, 0.005). Conclusion Serum UA, NT-proBNP and VS-2 levels can effectively reflect the cardiac function and disease progression of CHF patients, and are significantly correlated with LVEF.
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  • Nishimura M, Maisel A S. Biomarkers: a window into the pathophysiology of atrial fibrillation in heart failure with reduced vs. preserved ejection fraction[J]. Eur Heart J, 2018, 39(43): 3876-3878.
    Sokolska J M, Sokolski M, Zymliński R, et al. Patterns of dyspnoea onset in patients with acute heart failure: clinical and prognostic implications[J]. ESC Heart Fail, 2019, 6(1): 16-26.
    闫青叶, 赵玉清, 袁桂莉, 等. 慢性心力衰竭患者血浆和肽素的水平及意义[J]. 中国老年学杂志, 2014, 34(2): 302-304.
    朱小山, 张红申, 杨峰, 等. CHF病人血清儿茶酚抑素、和肽素水平与心力衰竭严重程度及短期心血管事件的关系分析[J]. 中西医结合心脑血管病杂志, 2019, 17(4): 566-569.
    朱文凯, 赵志鹏, 韩国彬. 慢性心衰患者血清尿酸、脑钠肽与左室射血分数水平相关性及预后分析[J]. 医学临床研究, 2018, 35(4): 753-755.
    陈薇, 胡汉宁, 黎安玲, 等. 慢性心力衰竭患者血浆NGAL水平变化及与NT-proBNP相关性的研究[J]. 临床心血管病杂志, 2015, 31(8): 864-867.
    丁风华, 陆林, 潘文麒, 等. 血清血管形成抑制素-2水平与心肌梗死后慢性心力衰竭预后的关系[J]. 国际心血管病杂志, 2016, 43(6): 375-378.
    中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2014[J]. 中华心血管病杂志, 2014, 42(2): 98-122.
    Romero R, Gaytán J M, Aguirre A, et al. The role of atrial fibrillation in the short-term outcomes of patients with acute heart failure[J]. Clin Res Cardiol, 2019, 108(6): 622-633.
    Khan H, Anker S D, Januzzi J L Jr, et al. Heart failure epidemiology in patients with diabetes mellitus without coronary heart disease[J]. J Card Fail, 2019, 25(2): 78-86.
    喻盛杰, 陈威. 慢性心力衰竭患者血清CA125及BNP水平与心功能的相关性[J]. 山东医药, 2017, 57(33): 49-51.
    祖秀光, 张少娟, 王鸿超, 等. 血清胱抑素C与慢性心力衰竭近期预后的相关性研究[J]. 河北医科大学学报, 2016, 37(12): 1365-1369.
    王丽丽, 张院, 余伦伦. 不同左心室射血分数心力衰竭患者NT-proBNP水平和5年生存率分析[J]. 海南医学, 2019, 30(12): 1513-1515.
    Dong X, Zhao G H, Li X, et al. Electrochemiluminescence immunoassay for the N-terminal pro-B-type natriuretic peptide based on resonance energy transfer between a self-enhanced luminophore composed of silver nanocubes on gold nanoparticles and a metal-organic framework of type MIL-125[J]. Mikrochim Acta, 2019, 186(12): 811-819.
    吴皓宇, 张春艳, 梁磊, 等. 慢性心力衰竭患者血清血管生成素-2的表达及临床意义[J]. 西安交通大学学报: 医学版, 2016, 37(3): 336-338

    , 348.
    彭雪, 王文娟, 牛洁婷. 血清胎盘生长因子与老年慢性心力衰竭患者血清NT-proBNP和近期预后的相关性分析[J]. 河北医科大学学报, 2019, 40(7): 768-772.
    杨鸿媚, 安广隶, 孙娜. NT-proBNP、LVEF在老年慢性充血性心力衰竭评估中的作用[J]. 解放军医药杂志, 2019, 31(2): 46-49.
    姚建荣, 陈锦, 文笃政. 慢性充血性心力衰竭患者血浆NGAL与NT-proBNP的相关性[J]. 中南医学科学杂志, 2018, 46(6): 583-585.
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