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QI Hongyan, WU Fang. Correlations between autoimmune encephalitis and peripheral blood immune indexes as well as erythrocyte immune indexes[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 42-45. DOI: 10.7619/jcmp.202015012
Citation: QI Hongyan, WU Fang. Correlations between autoimmune encephalitis and peripheral blood immune indexes as well as erythrocyte immune indexes[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 42-45. DOI: 10.7619/jcmp.202015012
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Correlations between autoimmune encephalitis and peripheral blood immune indexes as well as erythrocyte immune indexes

  • Department of Neurology, Xi'an City Children's Hospital, Xi'an, Shaanxi, 710003

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  • Received Date: January 12, 2020
  • Published Date: September 09, 2020
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    • Abstract
  • Objective To explore the correlation between disease condition of children with autoimmune encephalitis(AE)and peripheral blood immune indexes as well as erythrocyte immune indexes. Methods Totally 80 AE children were selected as observation group, and 40 healthy children with physical examination were selected as control group. The levels of cellular immune indexes were compared between the two groups, and their correlations with AE were analyzed. Results The levels of CD3+, CD4+, CD4+/CD8+ and natural killer cells(NK cells)in the observation group were significantly lower than those in the control group(P<0.05), and the level of CD8+ in the observation group was significantly higher than that in the control group(P<0.05). The erythrocyte immune affinity receptor(FEER), erythrocyte immune factor complex rosette(RBC-ICR), erythrocyte C3b immune receptor rosette(RBC-C3bR), electrophoresis index, aggregation index and rigidity index of observation group were significantly lower than those of control group(P<0.05). Taking AE as independent variable, CD3+, CD4+, CD4+/CD8+, CD8+, NK cells, FEER, RBC-ICR and RBC-C3bR were used as dependent variables. Correlation analysis showed that AE was positively correlated with CD8+(r=0.657, P<0.05), and AE was negatively correlated with CD3+, CD4+, CD4+/CD8+, NK cells, FEER, RBC-ICR and RBC-C3bR cells(r=-0.758, -0.635, -0.768, -0.814, -0.987, -0.765, -0.854, P<0.05). Conclusion There are correlations between peripheral blood immune indexes, erythrocyte immune indexes and disease condition in AE children.
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    • References (15)
  • 樊森, 张霞, 郑帼, 等. 儿童自身免疫性脑炎的诊疗进展[J]. 临床神经病学杂志, 2018, 31(4):307-309.
    GARG R K, KUMAR N, RIZVI I, et al. Fulminant subacute sclerosing panencephalitis mimicking autoimmune encephalitis[J]. Pediatr Infect Dis J, 2019, 38(3):e64-e75.
    张轶凡. 自身免疫性脑炎(AE)临床鉴别诊断及治疗分析[J]. 中国继续医学教育, 2017, 9(16):105-107.
    中华医学会神经病学分会. 中国自身免疫性脑炎诊治专家共识[J]. 中华神经科杂志, 2017, 50(2):91-98.
    DALE R C, GORMAN M P, LIM M. Autoimmune encephalitis in children:clinical phenomenology, therapeutics, and emerging challenges[J]. CurrOpin Neurol, 2017, 30(3):334-344.
    李春, 黄波, 韦朝阳. 自身免疫性脑炎发病机制研究新进展[J]. 当代医学, 2018, 24(12):185-186.
    刘冠亚, 周晓慧, 范慧敏. T细胞亚群与心力衰竭患者预后的相关临床研究进展[J]. 心血管病学进展, 2019, 40(1):5-8.
    FIGLEROWICZ M, KEMNITZ P, MANIA A, et al. Autoimmune encephalitis with GABAA receptor antibodies in a 10-year-old girl[J]. Clin Neurol Neurosurg, 2018, 164(7):160-163.
    刘夏青, 谢婷, 陈芳, 等. 自身免疫性脑炎患儿外周血T淋巴细胞亚群、红细胞免疫及血浆游离氨基酸的表达水平及临床意义[J]. 临床和实验医学杂志, 2019, 18(12):1287-1290.
    FOMINYKH V, BRYLEV L, GASKIN V, et al. Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis[J]. Metab Brain Dis, 2019, 34(5):1473-1485.
    刘的, 张习伦, 李济世, 等. 自身免疫性脑炎患儿的细胞免疫及体液免疫功能特征研究[J]. 脑与神经疾病杂志, 2019, 27(7):450-454.
    傅卓, 杨光路, 李晓华, 等. 十例不伴肿瘤的儿童自身免疫性脑炎病例分析[J]. 中国小儿急救医学, 2018, 25(11):863-866.
    STEINER J, PRÜSS H, KÖHLER S, et al. Autoimmune encephalitis with psychosis:Warning signs, step-by-step diagnostics and treatment[J]. World J Biol Psychiatry, 2018, 45(6):1-14.
    郝丹丹. 醒脑静注射液联合胎盘多肽对病毒性脑炎患儿外周血细胞因子、氧化应激和免疫功能的影响[J]. 河北医药, 2017, 39(11):1647-1649.
    STAFFORD E G, KORTUM A, CASTEL A, et al. Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease[J]. J Vet Intern Med, 2019, 33(5):2175-2182.
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