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LYU Jing, WANG Junhua. Correlation between plasma thrombomodulin level and early prognosis in patients with radial coronary artery bypass grafting[J]. Journal of Clinical Medicine in Practice, 2020, 24(18): 22-25. DOI: 10.7619/jcmp.202018006
Citation: LYU Jing, WANG Junhua. Correlation between plasma thrombomodulin level and early prognosis in patients with radial coronary artery bypass grafting[J]. Journal of Clinical Medicine in Practice, 2020, 24(18): 22-25. DOI: 10.7619/jcmp.202018006
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Correlation between plasma thrombomodulin level and early prognosis in patients with radial coronary artery bypass grafting

  • Department of Cardiac Surgery, Hanzhong City Central Hospital in Shaanxi Province, Hanzhong, Shaanxi, 723000

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  • Received Date: July 04, 2020
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    • Abstract
  • Objective To analyze the correlation between plasma thrombomodulin(TM)level and early prognosis in patients with radial coronary artery bypass grafting. Methods According to plasma TM level within 24 h after operation, 193 patients with radial coronary artery bypass grafting were divided into low TM group(n=97)and high TM group(n=96). According to incidence of cardiovascular and cerebrovascular events within 6 months after discharge, the patients were divided into good prognosis cases(n=121)and poor prognosis cases(n=72). The level of plasma TM was detected by ELISA. The general information, operation condition, complicated diseases conditions and prognosis were analyzed in both groups. The factors influencing the early prognosis of patients with radial coronary artery bypass grafting were analyzed. Results Compared with the low TM group, a higher body mass index(BMI), a lower left ventricular ejection fraction(LVEF)and a higher ratio of cases with smoking history were found in high TM group, and differences were statistically significant(P<0.05). Compared with the low TM group, higher ratios of cases with type 2 diabetes mellitus as well as new and old myocardial infarction were found in high TM group, and differences were statistically significant(P<0.05). The good prognosis rate of the high TM group was significantly lower than that of the low TM group(P<0.05). Multivariate Logistic regression analysis showed that TM, new and old myocardial infarction were the independent risk factors for adverse prognosis of patients after radial coronary artery bypass grafting(P<0.05), and LVEF was a protective - factor for adverse prognosis after radial coronary artery bypass grafting(P<0.05). Conclusion The plasma TM level is related to the preoperative physical condition of patients. The incidence of adverse cardiovascular and cerebrovascular events in patients with high TM level is higher than that in patients with low TM level, and the change of TM level is of great significance in evaluating the prognosis of patients with coronary heart disease.
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  • KIM D J, LEE S H, JOO H C, et al. Effect of the proximal anastomosis site on mid-term radial artery patency in off-pump coronary artery bypass[J]. Eur J Cardiothorac Surg, 2018, 54(3): 475-482.
    孙立春. 120例冠状动脉搭桥手术患者的护理体会[J]. 中国医药指南, 2018, 16(14): 242-242.
    NICHOLS S, TAYLOR C, PAGE R, et al. Is cardiorespiratory fitness related to cardiometabolic health and all-cause mortality risk in patients with coronary heart disease?A CARE CR Study[J]. Sports Med Open, 2018, 4(1): 22-33.
    杨维, 张悟棠, 孔永梅. 术前CRP水平与冠状动脉旁路移植术患者预后的关系[J]. 慢性病学杂志, 2019, 20(10): 1455-1458.
    PAI V C, LO I C, HUANG Y W, et al. The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells[J]. J Biomed Sci, 2018, 25(1): 14-27.
    李鑫辉, 黄淼鑫, 杜建芳, 等. 丹参通络解毒汤联合骨髓干细胞移植对急性心肌梗死大鼠心肌纤维化的影响及其机制[J]. 北京中医药大学学报, 2019, 42(8): 655-661.
    陈富荣. 冠状动脉粥样硬化性心脏病的预防诊断与治疗现状[J]. 新医学, 2005, 36(11): 626-627.
    胡中耀. 不同途径介入治疗对高龄冠心病患者近期和远期预后影响分析[J]. 中国血液流变学杂志, 2018, 28(3): 283-284.
    ZHANG Y, BAI Y, CHEN M, et al. The safety and efficiency of intravenous administration of tranexamic acid in coronary artery bypass grafting(CABG): a meta-analysis of 28 randomized controlled trials[J]. BMC Anesthesiol, 2019, 19(1): 104-117.
    UELAND T, KERBLOM A, GHUKASYAN T, et al. Osteoprotegerin is associated with major bleeding but not with cardiovascular outcomes in patients with acute coronary syndromes: Insights from the PLATO(platelet inhibition and patient outcomes)trial[J]. J Am Heart Assoc, 2018, 7(2): 1-12.
    叶攀, 杨丹, 蔡三金, 等. 珍斛颗粒对肝阳上亢型高血压病患者血管内皮细胞保护作用实验研究[J]. 湖北中医杂志, 2019, 41(6): 3-7.
    WEI Y J, LAI B, LIU H L, et al. Effect of cigarette smoke extract and nicotine on the expression of thrombomodulin and endothelial protein C receptor in cultured human umbilical vein endothelial cells[J]. Mol Med Rep, 2017, 17(1): 1724-1730.
    王聪霞, 范雅洁. 冠心病血管内皮损伤与血管重构的研究进展[J]. 西安交通大学学报: 医学版, 2018, 39(4): 455-458.
    郭素萍, 刘军, 高传玉, 等. 冠心病患者血管重建后吸烟状态对临床预后的影响[J]. 重庆医学, 2017, 46(7): 892-895.
    LAVIE C J, CARBONE S, AGARWAL M A. An obesity paradox with myocardial infarction in the elderly[J]. Nutrition, 2018, 46(1): 122-123.
    阿孜古·居买, 米娜瓦尔·司拉木. 慢性肾功能不全患者血栓调节蛋白与心脑血管并发症关系的探讨[J]. 临床医药文献电子杂志, 2018, 5(28): 34-36.
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