Study on predictive effect of serum beta human chorionic gonadotropin on unruptured tubal pregnancy treated by methotrexate

XU Jian; HU Lisheng; GAO Zhiwen

doi:10.7619/jcmp.20210878

Journal of Clinical Medicine in Practice > 2021 > 25(10): 103-106. > DOI: 10.7619/jcmp.20210878

XU Jian, HU Lisheng, GAO Zhiwen. Study on predictive effect of serum beta human chorionic gonadotropin on unruptured tubal pregnancy treated by methotrexate[J]. Journal of Clinical Medicine in Practice, 2021, 25(10): 103-106. DOI: 10.7619/jcmp.20210878

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Study on predictive effect of serum beta human chorionic gonadotropin on unruptured tubal pregnancy treated by methotrexate

1.
Department of Obstetrics and Gynecology, Zunhua City People's Hospital of Hebei Province, Tangshan, Hebei, 064200
2.
Department of Obstetrics and Gynecology, Maternal and Child Health Care Centre of Zunhua City, Tangshan, Hebei, 064200

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Received Date: March 02, 2021
Available Online: May 07, 2021
Published Date: May 27, 2021

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Abstract

Abstract

Objective To investigate predictive effect of serum beta human chorionic gonadotropin(β-HCG) on unruptured tubal pregnancy treated by methotrexate(MTX).
Methods A total of 197 patients with unruptured tubal pregnancy treated with MTX were selected and divided into success group (n=138) and failure group (n=59) according to the results of MTX treatment. The changes of blood β-HCG levels in the two groups were compared, and the sensitivity and specificity of blood β-HCG in predicting therapeutic efficacy of MTX were analyzed by Receiver Operating Characteristic (ROC) curve.
Results In the successful group, ratio of patients with the level of β-HCG decreased by 91.30%(126/138)on the fourth day was significantly higher than 20.34%(12/59) in those of the failure group(P < 0.05). The change rate of β-HCG ranging from the first day to the fourth day and β-HCG levels at 4 and 7 days after administration of two groups showed significant differences(P < 0.05). ROC curve analysis results showed that the β-HCG level on the 1st day was the highest in specificity, and was the highest on the 4th day in sensitivity. Comprehensive analysis showed that β-HCG level on the 4th day had a higher predictive value for MTX treatment outcomes. Out of 197 patients, 11 had nausea and vomiting, and 5 had slight increase of transaminase level.
Conclusion For asymptomatic and stable ectopic pregnancy women in hemodynamics, it is a safe and effective and choice to predict the effect of MTX in the treatment of unruptured tubal pregnancy through the changes of serum β-HCG.
- ectopic pregnancy,
- methotrexate,
- β-human chorionic gonadotropin,
- receiver operating characteristic curve,
- prediction efficacy

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References (23)

References

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Study on predictive effect of serum beta human chorionic gonadotropin on unruptured tubal pregnancy treated by methotrexate