Relationship of vitamin D deficiency with risk factors of cardiovascular and metabolic disorders in obese children

LIU Lianqin; LI Lei; LYU Yanguan

doi:10.7619/jcmp.20213317

Journal of Clinical Medicine in Practice > 2022 > 26(3): 68-71, 75. > DOI: 10.7619/jcmp.20213317

LIU Lianqin, LI Lei, LYU Yanguan. Relationship of vitamin D deficiency with risk factors of cardiovascular and metabolic disorders in obese children[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 68-71, 75. DOI: 10.7619/jcmp.20213317

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Relationship of vitamin D deficiency with risk factors of cardiovascular and metabolic disorders in obese children

1.
Department of Laboratory Medicine, Huai'an Maternal and Child Health Hospital of Jiangsu Province, Huai'an, Jiangsu, 223002
2.
Department of Neonatology, Huai'an Maternal and Child Health Hospital of Jiangsu Province, Huai'an, Jiangsu, 223002

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Received Date: August 16, 2021
Available Online: March 10, 2022
Published Date: February 14, 2022

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Abstract

Abstract

Objective To investigate the relationship of vitamin D deficiency with risk factors of cardiovascular and metabolic disorders in obese children.
Methods Fifty obese children were selected as obese group and 50 healthy children were selected as control group. The risk factors of cardiovascular and metabolic disorders were compared in children between the obese group and the control group, vitamin D deficiency and non-vitamin D deficiency children in the obese group, and children with vitamin D deficiency and non-vitamin D deficiency in the control group. The correlations between 25-hydroxyvitamin D level and other indexes were analyzed.
Results Body mass index (BMI), the homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglyceride, low-density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT), ratio of vitamin D deficiency, right carotid intima-media thickness (CIMT) and left CIMT in the obesity group were significantly higher than those in the control group (P < 0.05). The 25-hydroxyvitamin D level was negatively correlated with age, body mass, BMI and left CIMT of all enrolled children (P < 0.05). In the obese children, 25-hydroxyvitamin D level was negatively correlated with age, body mass, BMI and left CIMT (P < 0.05).
Conclusion Serum 25-hydroxyvitamin D level in the obese children is significantly correlated with cardiovascular risk factors of CIMT. It is not associated with HOMA-IR, total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL-C and other risk factors for metabolic disorders.
- obesity,
- vitamin D deficiency,
- children,
- cardiovascular,
- homeostasis model assessment-estimated insulin resistance,
- metabolic disorders

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References

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