Establishment of a Nomogram for prognosis of liver metastasis in patients with non-small cell lung cancer

DENG Yueyang; LIAO Zhixiao; ZHU Jinli; ZHOU Jingxu; DONG Shuo; JIA Yingjie

doi:10.7619/jcmp.20223574

Journal of Clinical Medicine in Practice > 2023 > 27(7): 18-24. > DOI: 10.7619/jcmp.20223574

DENG Yueyang, LIAO Zhixiao, ZHU Jinli, ZHOU Jingxu, DONG Shuo, JIA Yingjie. Establishment of a Nomogram for prognosis of liver metastasis in patients with non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 18-24. DOI: 10.7619/jcmp.20223574

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Establishment of a Nomogram for prognosis of liver metastasis in patients with non-small cell lung cancer

DENG Yueyang^{1, 2},
LIAO Zhixiao³,
ZHU Jinli^{1, 2},
ZHOU Jingxu⁴,
DONG Shuo^{1, 2},
JIA Yingjie^{1, 2, ,}

1.
Department of Oncology, the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193
2.
the National Clinical Medical Research Center for Acupuncture of Traditional Chinese Medicine, Tianjin, 300193
3.
the First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510405
4.
Department of Oncology, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510405

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Received Date: November 29, 2022
Revised Date: March 14, 2023
Available Online: April 22, 2023

Graphical Abstract

Abstract

Abstract

Objective
To analyze the clinical characteristics and prognostic factors of non-small cell lung cancer (NSCLC) patients with liver metastasis, and to construct a prognostic nomogram.
Methods
A total of 79 977 NSCLC patients with complete clinical information were collected from the Surveillance, Epidemiology, and End Results (SEER) database, and were divided into liver metastasis group and non-liver metastasis group. The liver metastasis group was randomly divided into training set and verification set. Chi square test was used to compare the clinical characteristics of liver metastasis group. The independent prognostic factors were screened by Cox regression analysis and used to construct nomograms for predicting 1- and 3-year overall survival (OS) and cancer-specific survival (CSS).
Results
Gender, age, primary site, histological classification, pathological grade, tumor size, T stage, N stage, distant metastasis, surgery, chemotherapy, radiotherapy were related to liver metastasis (P < 0.01). Multivariate analysis found that gender, age, tumor size, histological type, pathological grade, primary site surgery, chemotherapy, bone metastasis, and brain metastasis were independent risk factor associated with OS and CSS (P < 0.05). Receiver operating characteristic (ROC) curve and calibration curve showed that the nomogram had good predictive performance. Risk stratification among patients was carried out based on the established nomograms, and the low-risk group had a better prognosis than the high-risk group.
Conclusion
The nomograms constructed in this study can more accurately predict the prognosis of NSCLC patients with liver metastasis.
- non-small cell lung cancer,
- liver metastasis,
- prognosis,
- nomogram,
- prediction model,
- the Surveillance, Epidemiology, and End Results database

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References (22)

References

[1]	SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
[2]	CAMPOS-BALEA B, DE CASTRO CARPEÍO J, MASSUTÑ B, et al. Prognostic factors for survival in patients with metastatic lung adenocarcinoma: an analysis of the SEER database[J]. Thorac Cancer, 2020, 11(11): 3357-3364. doi: 10.1111/1759-7714.13681
[3]	FANG Y J, SU C X. Research progress on the microenvironment and immunotherapy of advanced non-small cell lung cancer with liver metastases[J]. Front Oncol, 2022, 12: 893716. doi: 10.3389/fonc.2022.893716
[4]	孟春柳, 徐利明, 魏佳, 等. 晚期小细胞肺癌和非小细胞肺癌不同转移部位预后意义的比较[J]. 中国肿瘤临床, 2019, 46(21): 1101-1106. doi: 10.3969/j.issn.1000-8179.2019.21.916
[5]	LI J, ZHU H G, SUN L, et al. Prognostic value of site-specific metastases in lung cancer: a population based study[J]. J Cancer, 2019, 10(14): 3079-3086. doi: 10.7150/jca.30463
[6]	CHOI M G, CHOI C M, LEE D H, et al. Different prognostic implications of hepatic metastasis according to front-line treatment in non-small cell lung cancer: a real-world retrospective study[J]. Transl Lung Cancer Res, 2021, 10(6): 2551-2561. doi: 10.21037/tlcr-21-206
[7]	RⅡHIMÄKI M, HEMMINKI A, FALLAH M, et al. Metastatic sites and survival in lung cancer[J]. Lung Cancer, 2014, 86(1): 78-84. doi: 10.1016/j.lungcan.2014.07.020
[8]	SHAN Q G, FAN Y L, GUO J, et al. Relationship between tumor size and metastatic site in patients with stage IV non-small cell lung cancer: a large SEER-based study[J]. PeerJ, 2019, 7: e7822. doi: 10.7717/peerj.7822
[9]	QIAO M, ZHOU F, HOU L K, et al. Efficacy of immune-checkpoint inhibitors in advanced non-small cell lung cancer patients with different metastases[J]. Ann Transl Med, 2021, 9(1): 34. doi: 10.21037/atm-20-1471
[10]	NOVELLO S, BARLESI F, CALIFANO R, et al. Metastatic non-small-cell lung cancer: ESMO clinical practice guide-lines for diagnosis, treatment and follow-up[J]. Ann Oncol, 2016(27 suppl 5): v1-v27.
[11]	王森, 魏元东, 赵智毅, 等. 非小细胞肺癌肝转移的危险因素分析及不同疗法的比较[J]. 中华疾病控制杂志, 2016, 20(9): 936-939. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ201609019.htm
[12]	孙基峰, 罗婧, 徐利明, 等. 广泛期小细胞肺癌肝转移治疗模式探讨[J]. 天津医科大学学报, 2019, 25(6): 577-580. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYK201906008.htm
[13]	许田慧, 刘宝刚. 晚期肺癌肝转移的综合治疗进展[J]. 现代肿瘤医学, 2019, 27(12): 2200-2203. doi: 10.3969/j.issn.1672-4992.2019.12.042
[14]	ZHU Z F, NI J J, CAI X W, et al. International consensus on radiotherapy in metastatic non-small cell lung cancer[J]. Transl Lung Cancer Res, 2022, 11(9): 1763-1795. doi: 10.21037/tlcr-22-644
[15]	MILLER K D, NOGUEIRA L, DEVASIA T, et al. Cancer treatment and survivorship statistics, 2022[J]. CA Cancer J Clin, 2022, 72(5): 409-436. doi: 10.3322/caac.21731
[16]	WEN S W, DAI L, WANG L, et al. Genomic signature of driver genes identified by target next-generation sequencing in Chinese non-small cell lung cancer[J]. Oncologist, 2019, 24(11): e1070-e1081. doi: 10.1634/theoncologist.2018-0572
[17]	JIANG P P, GENG L Y, MAO Z Y, et al. First-line chemotherapy plus immune checkpoint inhibitors or bevacizumab in advanced non-squamous non-small-cell lung cancer without EGFR mutations or ALK fusions[J]. Immunotherapy, 2022: Online ahead of print.
[18]	GRANT J M, HERBST S R, GOLDBERG B S, 等. 驱动基因阴性的转移性非小细胞肺癌最佳免疫治疗方案的选择[J]. 中国肺癌杂志, 2022, 25(7): 555-582. https://www.cnki.com.cn/Article/CJFDTOTAL-FAIZ202207018.htm
[19]	张国伟, 程瑞瑞, 张国俊, 等. 有或无肝转移的晚期非小细胞肺癌应用纳武利尤单抗的疗效差异: 一项回顾性队列研究[J]. 现代肿瘤医学, 2021, 29(15): 2615-2619. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZL202115009.htm
[20]	方瑜佳, 周娟, 苏春霞. 非小细胞肺癌肝转移免疫微环境及未来干预策略[J]. 中国癌症杂志, 2020, 30(10): 750-758. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGAZ202010005.htm
[21]	SHENG L, GAO J, XU Q, et al. Selection of optimal first-line immuno-related therapy based on specific pathological characteristics for patients with advanced driver-gene wild-type non-small cell lung cancer: a systematic review and network meta-analysis[J]. Ther Adv Med Oncol, 2021, 13: 17588359211018537.
[22]	CORRAO G, MARVASO G, FERRARA R, et al. Stereotatic radiotherapy in metastatic non-small cell lung cancer: combining immunotherapy and radiotherapy with a focus on liver metastases[J]. Lung Cancer, 2020, 142: 70-79.

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Establishment of a Nomogram for prognosis of liver metastasis in patients with non-small cell lung cancer