Effect observation of postoperative radiotherapy combined with systemic chemotherapy in treating patients with cervical cancer in early stage

Objective To evaluate the clinical effect of postoperative radiotherapy combined with systemic chemotherapy in treating patients with cervical cancer in early stage.

Methods The clinical materials of 152 patients with postoperative radiotherapy in stage Ⅰb to Ⅱa of cervical cancer were retrospectively analyzed, and they were divided into radiotherapy combined with systemic chemotherapy group and simple radiotherapy group, with 76 cases in each group. The clinical materials and conditions of recurrence and metastasis were compared between the two groups.

Results In the 152 patients with cervical cancer in early stage, the recurrence rate after postoperative radiotherapy was 20.39%. Univariate and multivariate analyses showed that vascular cancer thrombus, deep interstitial infiltration, parametrial infiltration and pelvic lymph node metastasis were the independent risk factors for postoperative recurrence of cervical cancer after radiotherapy (P < 0.05). In the radiotherapy combined with systemic chemotherapy group, the ratios of patients with adenocarcinoma and other pathological types, larger tumor diameter, vascular cancer thrombus and pelvic lymph node metastasis were significantly higher than those in the simple radiotherapy group (P < 0.05 or P < 0.01). In the 88 elderly (≥50 years old) patients with cervical cancer in early stage, univariate and multivariate analyses showed that parametrial invasion and pelvic lymph node metastasis were the independent risk factors of postoperative recurrence after radiotherapy in elderly patients with cervical cancer (P < 0.05).

Conclusion Vascular cancer thrombus, deep interstitial infiltration, parametrial infiltration and pelvic lymph node metastasis are the independent risk factors for postoperative recurrence after radiotherapy in patients with cervical cancer in early stage. For early cervical cancer patients with moderate to high risk factors, postoperative radiotherapy combined with systemic chemotherapy can help reduce risk of recurrence. Parametrial infiltration and pelvic lymph node metastasis are the independent risk factors of postoperative recurrence in elderly patients with cervical cancer in early stage.